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#TumorMicroenvironments
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Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
1 month ago
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#Dysadherin drives #ColorectalCancer adaptation to acidic #TumorMicroenvironments by activating integrin–FAK–STAT3 signaling to upregulate CA9, promoting survival, metabolic reprogramming, and progression.

#OpenAccess in #STTT: doi.org/10.1038/s413...

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Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
2 months ago
Post image

#Dysadherin drives #ColorectalCancer adaptation to acidic #TumorMicroenvironments via integrin/FAK/STAT3‑mediated CA9 upregulation, sustaining pH #homeostasis and establishing the dysadherin–CA9 axis as a targetable driver of CRC progression.

#STTT: doi.org/10.1038/s413...

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