Today is #RareDiseaseDay. At AASLD, we are committed to advancing education, research, and advocacy that support individuals living with rare #liverdiseases.

View these perspectives from AASLD members who are driving progress in rare liver disease research, diagnosis, and care.

In hopes of discovering new treatments for #LiverDiseases, @mit.edu engineers have designed a new type of tissue model that more accurately mimics the architecture of the liver, including blood vessels and immune cells.

Learn about the mini “liver-on-a-chip": https://bit.ly/4tiIpFq

This review summarizes the role of FGF15/19–FGFR4 signaling in regulating liver physiology and in pathogenesis of inflammation & #Tumorigenesis, highlighting its potential as a #Biomarker & #TherapeuticTarget in #LiverDiseases.

#OpenAccess: doi.org/10.1016/j.ge...

Classification of Nonalcoholic Fatty Liver Grades using Pre-Trained Convolutional Neural Networks and a Random Forest Classifier on B-Mode Ultrasound Images Background: Nonalcoholic Fatty Liver Disease (NAFLD) as a prevalent condition can significantly have health implications. Early detection and accurate grading of NAFLD are essential for effective mana...

Classification of Nonalcoholic Fatty Liver Grades using Pre-Trained Convolutional Neural Networks and a Random Forest Classifier on B-Mode Ultrasound Images

#IBPE #FattyLiver #UltrasoundImages #LiverDiseases #Convolutional #NeuralNetworks #RandomForest

DOI: doi.org/10.31661/jbp...

An overview of the #Epidemiology & characteristics of #LiverDiseases, the mechanisms underlying their pathogenesis, with discussion on the current #Diagnostic & treatment modalities, and potential #TherapeuticTargets. @pku1898.bsky.social

#OpenAccess: doi.org/10.1038/s413...

Regenerative medicine aims to restore or replace damaged tissues and organs, and is emerging as a potential solution for various #liverdiseases including biliary atresia https://www.nature.c

This review presents an extensive analysis of CHI3L1 and its models as #biomarkers for #LiverDiseases, explores its role in #LiverPathology, and highlights its potential as a #diagnostic tool and #therapeutic target. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

Reviewing the #epidemiology, characteristics, and the mechanisms underlying #LiverDiseases, with insights into the diagnostics, treatments, and #TherapeuticTargets in their management. #medsky @pku1898.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

Scientists from ‪@ucl.ac.uk‬l reveal that #CD36 plays a pro-cholestatic role through its regulation of rhythmic #BileAcid synthesis and underscore its potential as a therapeutic target for cholestatic #LiverDiseases by modulating the HMGCR/CYP7A1 axis.

www.sciencedirect.com/science/arti...

Scientists from @ucl.ac.ukl reveal that #CD36 plays a pro-cholestatic role through its regulation of rhythmic #BileAcid synthesis and underscore its potential as a therapeutic target for cholestatic #LiverDiseases by modulating the HMGCR/CYP7A1 axis. #medsky

www.sciencedirect.com/science/arti...

This review describes m6A readers, summarizes the recognition and regulatory mechanisms of m6A readers on #mRNA, and focuses on the biological functions and mechanisms of m6A readers in #livercancer, #NAFLD and other #liverdiseases. #medsky

#OpenAccess:

Mitochondrial dysfunction: A promising therapeutic target for liver diseases

This review comprehensively summarizes the common types of #Mitochondrialdysfunction and their underlying mechanisms and discusses mitochondrion-centric therapies for treating #liverdiseases. #Oxidativestress #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

FGF21-mediated autophagy: Remodeling the homeostasis in response to stress in liver diseases

This review summarizes the mechanisms of #FGF21 (fibroblast growth factor 21)-mediated #autophagy and its role in stress defense in #LiverDiseases, highlighting its potential for future clinical application. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Role of chitinase-3-like protein 1 in liver diseases: A comprehensive review

This comprehensive review summarizes the application of chitinase-3-like protein 1 (CHI3L1) and CHI3L1-based models as #biomarkers for various #LiverDiseases and highlights the CHI3L1-mediated pathways in liver disease pathology. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Diverse functions of SOX9 in liver development and homeostasis and hepatobiliary diseases

A systematic review from @fudan-university.bsky.social on recent advances in the role of #SOX9 in #hepatobiliary development, homeostasis, and disease, as well as its potential as a novel #biomarker and target for the treatment of major #LiverDiseases. #medsky

#OpenAccess: buff.ly/9n32FaA

dkNET | dkNET Webinar "Metabolomics Workbench – A gateway to multiomics integration and disease biology" Come join us for a webinar presented by Dr. Shankar Subramaniam on Friday, February 128 2025 to learn more about Metabolomics Workbench!

dkNET Webinar: Metabolomics Workbench
🔬Discover how the #Metabolomics Workbench supports multiomics research & disease insights!
📅 Feb 28 | 11 am PT
🎤 Shankar Subramaniam, PhD
🔗 https://buff.ly/4gU7G1b
#Bioinformatics #diabetes #liverdiseases #omics

Weed Killer 2,4-D’s Adverse Effect on the Liver Adds to List of Hazards from Food, Lawn, and Water Residue A review published in Toxics finds the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) causes significant changes in liver structure and function.

Widely used #weedkiller 2,4-dichlorophenoxyacetic acid (#24d) found to be associated with significant changes in #liver structure & function in new review @ufcinforma @ufg_oficial @UTAD_oficial 📈 #liverdiseases #oxidativestress Blog:

ow.ly/lHC250QG9FY