SOX9 shapes liver development, homeostasis & hepatobiliary disease progression.
#SOX9 #Hepatobiliary #GeneRegulation #HepatologyResearch
www.sciencedirect.com/science/arti...

PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Turnover of mammal sex #chromosomes in the Sry-deficient Amami spiny rat is due to male-specific upregulation of #Sox9

www.pnas.org/doi/10.1073/... #SRY

Protein arginine methyltransferase 7-mediated arginine mono-methylation stabilizes SRY-box transcription factor 9 to promote non-small cell lung cancer progression - Molecular Biomedicine Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, underscoring the need for deeper insights into its molecular mechanisms. The SRY-box transcription fac...

#Research
Protein arginine methyltransferase 7-mediated arginine mono-methylation stabilizes SRY-box transcription factor 9 to promote non-small cell lung cancer progression doi.org/10.1186/s435...

#NSCLC #ArginineMono_methylation #SOX9 #PRMT7 #R160 #FBXW7 #KEAP1

Diverse functions of SOX9 in liver development and homeostasis and hepatobiliary diseases

A systematic review from @fudan-university.bsky.social on recent advances in the role of #SOX9 in #hepatobiliary development, homeostasis, and disease, as well as its potential as a novel #biomarker and target for the treatment of major #LiverDiseases. #medsky

#OpenAccess: buff.ly/9n32FaA

Profibrotic role of the SOX9–MMP10–ECM biosynthesis axis in the tracheal fibrosis after injury and repair

This study demonstrates the profibrotic activity of #SOX9 in fibroblast activation, cell proliferation, #ExtracellularMatrix (ECM) deposition, and cell #apoptosis in rat tracheal fibroblast (RTF) cells through activation of Wnt/β-catenin signaling. #medsky

#OpenAccess: buff.ly/yyIx9P2

Online today: #SOX9 -dependent #fibrosis drives renal function in #nephronophthisis

by M. Patel, L. Tsiokas & colleagues at University of Oklahoma Health Sciences Center

➡️ doi.org/10.1038/s443...

Check out our publication from earlier this year out of Liu Lab in @pnas.org! "Variants in the SOX9 transactivation middle domain induce axial skeleton dysplasia and scoliosis" doi.org/10.1073/pnas... #CCMBUSC #USCResearch #SOX9 #scoliosis #Science #Research

Mutations in the #SOX9 TAM domain reduce SOX9 stability. SOX9 TAM mutants have normal spine development but display later #scoliosis. Mutant IVDs show reduction of ECM genes and Adgrg6, suggesting a Adgrg6-Sox9 feed-forward pathway in the regulation of spine stability.
www.pnas.org/doi/epub/10....