Two good news today... This work was led by Friederike Petzold in the lab, congrats to all the coauthors!
#kidney #ciliopathies #nephronophthisis

journals.lww.com/cjasn/abstra...

Structure-Activity Analysis Reveals Perturbed Cilia-Jun N-Terminal Kinase Signaling in MAPKBP1-Associated Kidney Disease Nephronophthisis (NPH) is a renal ciliopathy characterized by chronic tubulointerstitial fibrosis. Despite discovery of multiple disease genes, mechanisms of NPH-associated kidney degeneration remain ...

New interesting paper on MAPKBP1, which sheds new light on its localization and function at #cilia! Many thanks to Ria and Jan for inviting us to participate in this exciting work! Congratulations to all collaborators!
#ciliopathies #kidney #nephronophthisis

www.kireports.org/article/S246...

Online today: #SOX9 -dependent #fibrosis drives renal function in #nephronophthisis

by M. Patel, L. Tsiokas & colleagues at University of Oklahoma Health Sciences Center

➡️ doi.org/10.1038/s443...