A comprehensive overview of #BileAcid (BA) metabolism alterations in #Sepsis, exploring the potential molecular mechanisms, while discussing the prospects & challenges of using BAs as diagnostic #Biomarkers & #TherapeuticTargets in sepsis.

#OpenAccess: doi.org/10.1016/j.ge...

Structure and mechanism of the human bile acid transporter OSTα–OSTβ - Nature Cryo-electron microscopy structures of the bile acid transporter OSTα–OSTβ, which has a key role in bile acid homeostasis, provide insight into its distinct architecture and mechanism of substrate tra...

The work reveals a unique dimer-of-heterodimers architecture and the structural basis of bile acid binding and transport, advancing our understanding of #BileAcid homeostasis and cholestasis.

doi.org/10.1038/s415...

#PekingUniversity #StructuralBiology #CryoEM #Biochemistry @nature.com

Scientists identify #microbiota‑derived #BileAcid isoLCA as a potent airway #immunomodulator via S1PR2‑driven metabolic reprogramming of #AlveolarMacrophages, reducing CXCL10, neutrophils, and #inflammation.

#OpenAccess in #STTT: doi.org/10.1038/s413...

New Spotlight alert! #Cryptosporidium passes the #bileacid test to survive, authored by @ryanpardy.bsky.social Danielle Karo-Atar & Irah King, highlighting a @cp-cellhostmicrobe.bsky.social article by L. David Sibley & colleagues.

authors.elsevier.com/a/1lqx55Eb1x...

This research from @ucl.ac.uk suggests that #CD36 plays a pro-cholestatic role by regulating rhythmic #BileAcid synthesis and its inhibition, highlighting its potential as a therapeutic target for #CholestaticLiverDiseases. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

Scientists from ‪@ucl.ac.uk‬l reveal that #CD36 plays a pro-cholestatic role through its regulation of rhythmic #BileAcid synthesis and underscore its potential as a therapeutic target for cholestatic #LiverDiseases by modulating the HMGCR/CYP7A1 axis.

www.sciencedirect.com/science/arti...

Scientists from @ucl.ac.ukl reveal that #CD36 plays a pro-cholestatic role through its regulation of rhythmic #BileAcid synthesis and underscore its potential as a therapeutic target for cholestatic #LiverDiseases by modulating the HMGCR/CYP7A1 axis. #medsky

www.sciencedirect.com/science/arti...

In this N&V, B. Attema and F. Kuipers @unigroningen.bsky.social discuss the study by Schoonjans & colleagues that reveals the important role of secondary #BileAcid signaling in colon #MucosalHealing after injury.

👉 doi.org/10.1038/s443...
👉Related article: doi.org/10.1038/s443...

Gut bacteria heal the colon EPFL scientists have uncovered how a gut bacterium, Clostridium scindens, aids in healing intestinal injuries by restoring bile acid balance. Their findings could pave the way for new treatments for u...

An interesting publication on #biotherapeutics to restore the compromised #bileacid signaling in ulcerative colitis! check it out! actu.epfl.ch/news/gut-bac...

The microbiota-derived bile acid taurodeoxycholic acid improves hepatic cholesterol levels in mice with cancer cachexia Alterations in bile acid profile and pathways contribute to hepatic inflammation in cancer cachexia, a syndrome worsening the prognosis of cancer patients. As the gut microbiota impinges on host me...

🎉New article from our team demonstating that a #microbiota derived #bileacid improves hepatic #cholesterol levels in mice with cancer #cachexia! Congratulations to Morgane Thibaut & Martin Roumain! Thanks to our collaborators, the FNRS and the @welbio.bsky.social www.tandfonline.com/doi/full/10....

Good time to acknowledge the father of #bileacid the late Alan F. Hofmann who „made the bile flow“ #UDCA publishing seminal papers e. g. in #Nature 1961 and 1965. Based on the kind of bile acid, he was able to solve some problems in evolutionary ambiguity amongst some non-mammal vertebrates

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In a nutshell: THAP7 can increase replication (#replicon & #infection) more than 10x in low passage Huh7! Fine balance between NR0B2 (= SHP) and FXR important for optimal #bileacid and #cholesterol #metabolism: HCV down by 2 log when too much NR0B2 around!