UDCA May Be Associated With Reduced Risk of Certain Cancers Research shows that treatment with UDCA is associated with a significantly lower risk of gastrointestinal, liver, and breast cancer in patients with PBC.

Treatment with ursodeoxycholic acid (#UDCA) is associated with a significantly lower risk of developing gastrointestinal, liver, and breast #Cancer in patients with primary biliary cholangitis (#PBC). @jamanetworkopen.com

Read more: https://bit.ly/4kbJMSk

#WorldCancerDay #RareDisease #Oncology

The Effects of Ursodeoxycholic Acid on Parkinson’S Disease, a Mechanistic Review of the Recent Evidence Can bile acids help Parkinson’s? Review finds UDCA/TUDCA reduce neuroinflammation & oxidative stress. #ParkinsonsDisease #UDCA

Can bile acids help Parkinson’s? Review finds UDCA/TUDCA reduce neuroinflammation & oxidative stress. #ParkinsonsDisease #UDCA
www.rimpacts.com/rd/p?c=10079... 📄DOI: doi.org/10.1007/s110...

Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner Statins are currently the most common cholesterol-lowering drug, but the underlying mechanism of statin-induced hyperglycemia is unclear. To investiga…

Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner #GLP1 #UDCA

www.sciencedirect.com/science/arti...

Randomized, controlled trial of the impact of ursodeoxycholic acid on glycemia in gestational diabetes mellitus: the GUARDS trial Gestational diabetes mellitus (GDM) is a pregnancy complication that can be associated with increased risks of adverse maternal and neonatal outcomes.…

Women with #GDM with high ursodeoxycholic acid levels in the blood following #UDCA treatment are more likely to have fasting glucose within recommended ranges, suggesting potential benefit in GDM management🤰

sciencedirect.com/science/arti... @cathwilliamson.bsky.social

Good time to acknowledge the father of #bileacid the late Alan F. Hofmann who „made the bile flow“ #UDCA publishing seminal papers e. g. in #Nature 1961 and 1965. Based on the kind of bile acid, he was able to solve some problems in evolutionary ambiguity amongst some non-mammal vertebrates

@EASLedu other question is whether there is benefit from starting #UDCA #bezafibrate combo as initial therapy. Studies lacking. #ILC2017

@EASLedu Dr. Coprechot: very impressive data in 2y RCT of bezafibrate vs. placebo among #PBC #UDCA non biochemical reponders #ilc2017