Scientists identify #microbiota‑derived #BileAcid isoLCA as a potent airway #immunomodulator via S1PR2‑driven metabolic reprogramming of #AlveolarMacrophages, reducing CXCL10, neutrophils, and #inflammation.

#OpenAccess in #STTT: doi.org/10.1038/s413...

6/12 He warns we may be "living through a slow-moving #immune decline crisis."

This is seen in rising shingles cases after #COVID bouts and new studies linking repeat #infections to rising #cancer rates in young people. A Brazilian study agrees, calling #SARS-CoV-2 a "complex #immunomodulator."

#IL2 is a powerful #immunomodulator, but the dual roles make it complex to use and many designer #mutations reduce #bioactivity or result in poor #production, reducing clinical utility. We designed #muteins specific for either #Tregs or #CD8 that also boost production by disrupting aggregation. 2/11