Directed disruption of IL2 aggregation and receptor binding sites produces designer biologics with enhanced specificity and improved production capacity The pleotropic nature of interleukin-2 (IL2) has allowed it to be used as both a pro-inflammatory and anti-inflammatory therapeutic agent, through pro…

Big thanks to the team at @campathology.bsky.social @babrahaminst.bsky.social @cbdresearch.bsky.social @i3suporto.bsky.social, plus everyone who contributed to the project! Here is hoping some of these #muteins make it to the clinic! 11/11

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#IL2 is a powerful #immunomodulator, but the dual roles make it complex to use and many designer #mutations reduce #bioactivity or result in poor #production, reducing clinical utility. We designed #muteins specific for either #Tregs or #CD8 that also boost production by disrupting aggregation. 2/11