Incredibly proud of post-bacc McKinlee Gobble presenting her poster on FGF21 signaling & insulin-mediated pseudoacromegaly at the 2026 WashU Pediatric Research Retreat! 🌟 Rare disease research, big impact. #FGF21 #RareDisease #PedsResearch #StoneLab

#Multiomics reveals reduced #FGF21 as a driver of #LiverAging, linking suppressed peroxisome and fatty acid pathways with cell cycle decline; FGF21 restoration boosts #antioxidant defense and regeneration, highlighting a therapeutic target.
#OpenAccess: doi.org/10.1016/j.ge...

Figure 1: Overview of the Study, showing two plots. Plot A is a heatmap. Plot B is a PCA analysis; x axis labeled PC1 (20.2%), y axis labeled PC2 (12.7%). Legend describes postnatal age in days, ranging from 0 to 35.

A rapid increase in #FGF21 during the first postnatal week identified preterm infants at higher risk for severe retinopathy of prematurity, suggesting early metabolic stress as a modifiable target. ja.ma/40ileO1

FGF21-mediated autophagy restores liver homeostasis under stress—promising direction for therapy.
#FGF21 #Autophagy #LiverDisease #MetabolicHealth #CellBiology
www.sciencedirect.com/science/arti...

Figure 1, Overview of the Study, shows two graphs. A is a heat map depicting randomization, severe ROP, center, gestational age, and postnatal age. B is a PCA analysis graph plotting postnatal age against PC1@20.2% and PC2@12.7%.

A rapid increase in #FGF21 during the first postnatal week identified preterm infants at higher risk for severe retinopathy of prematurity, suggesting early metabolic stress as a modifiable target. ja.ma/4prG33P

A two-strata #EnergyFlux system, pivotal for cardiac energetics, is regulated by #FGF21, which spatiotemporally optimizes interorgan & transcardiac metabolite flux and intracardiac mitochondrial energy sufficiency.

#STTT #OpenAccess: doi.org/10.1038/s413...

Sex Differences in Ketogenic Diet Response Reveal Gonadal Hormone Interaction With FGF21 in Mice Abstract. Although indicated as adjunctive therapy for seizure disorders, ketogenic diets (KDs) have gained popularity for weight loss and mitigating the m

Sex Differences in #KetogenicDiet Response Reveal #GonadalHormone Interaction With #FGF21 in Mice. Read more in #JES: bit.ly/435lp14 @endocrinesociety.bsky.social

Identification of FGF21‐inducing rare sugars that reduces sugar appetite in male BL/6 mice Dietary sugars induced FGF21 secretion from the liver and activate hypothalamic oxytocin neurons to reduce furter sugar intake. Replacing obesogenic dietary sugars with FGF21-inducing rare sugars can...

This study identifies rare natural #sugars, (sweet, yet low calorie, poorly metabolized in the body and non-obesogenic), that induce #FGF21 production and suppress sugar appetite in mice.
doi.org/10.14814/phy...
#Obesity #Diet #Endocrine #Metabolism

The #StressHormone #FGF21 drives a hierarchical, two-pronged energy flux system pivotal for cardiac energetic efficiency, comprising intracardiac mitochondrial energy sufficiency and systemic-transcardiac metabolite flux.

#STTT #OpenAccess: doi.org/10.1038/s413...

Roche acquired 89bio and its #FGF21 analogue, pegozafermin, a leading candidate for #MASH. With trials focused on fibrosis improvement and MASH resolution without fibrosis worsening, Roche sees pegozafermin as a best-in-class therapy.

Unpicking the effects of FGF21 on longevity Nature Reviews Endocrinology - Unpicking the effects of FGF21 on longevity

Unpicking the effects of FGF21 on longevity - Thanks to Claire Greenhill @natrevendo.nature.com for this apt research highlight on our FGF21 longevity paper! @utswdiabetes @cp-cellmetabolism.bsky.social #metabolism #FGF21 rdcu.be/etg69

New article to read! Higher circulating FGF21, lower protein intake, and lower muscle mass: Associations with a higher risk of mortality

➡️ Highlighting the potential relevance of protein intake and maintenance of muscle mass in long-term health

🔗 doi.org/10.1111/joim.20099

#FGF21

The Brain-Liver Connection: Hormone FGF21 Reverses Fatty Liver Disease A groundbreaking study reveals how the hormone FGF21 reverses fatty liver disease — not by acting directly on the liver, but by signaling the brain to take control. This could redefine future treatments for metabolic disorders.

This brain-signaling hormone reverses fatty liver—even on a bad diet. Is FGF21 the future of metabolic therapy? #FattyLiver #FGF21 #MetabolicHealth

FGF21-mediated autophagy: Remodeling the homeostasis in response to stress in liver diseases

This review summarizes the mechanisms of #FGF21 (fibroblast growth factor 21)-mediated #autophagy and its role in stress defense in #LiverDiseases, highlighting its potential for future clinical application. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Fibroblast growth factor 21: An emerging pleiotropic regulator of lipid metabolism and the metabolic network

This review details the mechanisms regulating #FGF21 production, its mechanism of action & biological functions, explores how it regulates #GlucoLipidMetabolism, and lays a theoretical foundation for future research on FGF21-targeted treatment of #MetabolicDiseases. #medsky

buff.ly/kO5JMsJ

FGF21 hormone can reverse fatty liver disease – BioNews Central A pioneering research study details how the hormone FGF21 (fibroblast growth factor 21) can reverse the effects of fatty liver disease in mice. ...

A pioneering research study details how the #hormone #FGF21 (#FibroblastGrowthFactor21) can reverse the effects of #FattyLiverDisease in mice.
#MASLD #MASH

Adipokines Pathogenesis in Heart Failure Explore the role of adipokines in heart failure pathogenesis, including ANGPTL2, FGF21, and osteopontin, and their impact on prediction, diagnosis, and prognosis.

Adipokines like #ANGPTL2, #FGF21, and #Osteopontin are pivotal in #HeartFailure pathogenesis, offering potential for advanced #Biomarkers in prediction, diagnosis, and prognosis.

#openaccess: cvia-journal.org/adipokines-p...

#Cardiology #MedicalResearch #HealthInnovation @scienceopen.bsky.social

How gut microbes and hormones shape your sweet tooth Scientists uncover how Ffar4 regulates sugar cravings through gut microbiota, revealing pantothenate as a key mediator to curb sugar intake.

How gut microbes and hormones shape your sweet tooth 🌱🔬🍭 www.news-medical.net/news/2025011... #GutHealth #Microbiome #MetabolicHealth #SugarCravings #FFAR4 #Pantothenate #Diabetes #GLP1 #FGF21 #Nutritional @naturemicrobiol.bsky.social

3/ First, we focused on #FGF21 and #GDF15, two metabokines affecting energy balance.
We found that GDF15 transiently increased upon diet-induced weight loss whereas FGF21 decreased following weight-loss maintenance with combined exercise and GLP-1 analog.

#FGF21 #代謝 #抗老

highlight of #EASLCongress was the ph2. presentation by ⁦@DrLoomba⁩ of #FGF21 #pegozafermin s/c every 2 weeks vs. placebo. Impressive data with ph3 to follo. Read the whole thing in today’s ⁦@NEJM⁩ ⁦@EASLnews⁩ ⁦@EASLedu⁩ https://dir.lat/ycH7DK