#Multiomics reveals reduced #FGF21 as a driver of #LiverAging, linking suppressed peroxisome and fatty acid pathways with cell cycle decline; FGF21 restoration boosts #antioxidant defense and regeneration, highlighting a therapeutic target.
#OpenAccess: doi.org/10.1016/j.ge...

Integrative analysis of the transcriptome and metabolome reveals the importance of hepatokine FGF21 in liver aging

A combination of integrated #Multiomics analysis and in vitro & in vivo studies identified hepatokine Fgf21 as an important target for inhibiting #LiverAging. Pharmacological interventions that increase FGF21 expression may help in the treatment of liver aging-related diseases.

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