UCLA Researchers Identify and Clear Senescent Macrophages to Reverse Fatty Liver Disease in Mice UCLA scientists have discovered a population of senescent “zombie” immune cells, specifically macrophages marked by p21 and TREM2 proteins, that accumulate in aging livers and drive chronic inflammation and fatty liver disease. In older mice, these dysfunctional cells can make up 60-80% of liver macrophages, compared to just 5% in young mice. The study found that excess cholesterol from high-fat diets accelerates this senescence process, turning normally protective macrophages into inflammatory drivers that worsen metabolic dysfunction-associated steatotic liver disease. When researchers used the senolytic drug ABT-263 to selectively eliminate these senescent macrophages, the results were striking: liver size normalized, inflammation dropped sharply, and fatty liver damage reversed dramatically even while the mice continued eating an unhealthy diet. Body weight also decreased by about 25%. Analysis of human liver biopsy data showed the same senescent macrophage signature is elevated in people with fatty liver disease. The findings support the geroscience idea that targeting core aging processes like cellular senescence could treat multiple age-related conditions, including fatty liver disease, atherosclerosis, and Alzheimer’s. While ABT-263 is too toxic for human use, the team is now searching for safer compounds. This research highlights macrophage senescence as a promising therapeutic target for both aging and metabolic liver disease, which affects 30-40% of people in areas like Los Angeles.

UCLA Researchers Identify and Clear Senescent Macrophages to Reverse Fatty Liver Disease in Mice

🤖 IA: It's clickbait ⚠️
👥 Usuarios: It's clickbait ⚠️

#senescentcells #fattyliverdisease #macrophages

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MCT4 alleviates #NAFLD by promoting #LipidCatabolism and reducing #steatosis through regulation of metabolic and inflammatory pathways, highlighting its role as a key lactate transporter and promising therapeutic target in #FattyLiverDisease.

#OpenAccess: doi.org/10.1016/j.ge...

Funded Research - PSI Foundation List of projects funded by PSI Foundation.

Dr. Marialena Mouzaki's study on intestinal microbiota, bile acids and non-alcoholic #FattyLiverDisease: psifoundation.org/funded-resea.... #LiverHealthMonth #LiverResearch @sickkidsvs.bsky.social @sickkidsto.bsky.social

March is Liver Health Month.

PSI-funded research is advancing care, from #Cirrhosis outcomes to post #COVID transplant health and #FattyLiverDisease.

Rare MET Gene Mutation Identified as a Direct Cause of Fatty Liver Disease Researchers at Mayo Clinic have discovered a rare mutation in the MET gene that can directly lead to metabolic dysfunction-associated steatotic liver disease, formerly known as nonalcoholic fatty liver disease. This mutation interferes with the liver's ability to process fat, causing fat accumulation, inflammation, fibrosis, and potentially cirrhosis or liver cancer. The discovery originated from a father-daughter pair who developed severe liver disease despite lacking common risk factors like diabetes or high cholesterol. Extensive genetic analysis revealed a single DNA letter change in the MET gene, disrupting liver fat metabolism. Subsequent examination of the Mayo Clinic Tapestry study, which includes DNA data from over 100,000 participants, found that about 1% of adults with fatty liver disease carried rare MET variants, with nearly 18% located in the same critical region as the original family. The findings highlight how rare genetic variants can underlie common diseases and emphasize the role of precision genomics in uncovering hidden causes. This discovery may guide future targeted therapies and improve diagnosis for millions at risk worldwide, showcasing the value of combining familial case studies with large-scale genomic research.

Rare MET Gene Mutation Identified as a Direct Cause of Fatty Liver Disease

🤖 IA: It's not clickbait ✅
👥 Usuarios: It's not clickbait ✅

#genemutation #fattyliverdisease #genomics

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Cannabis Compounds CBD and CBG Slash Liver Fat and Restore Metabolic Health CBD and CBG may help the liver recharge and clean itself—offering a promising new plant-based strategy against fatty liver disease.

"Their findings suggest that Cannabidiol (CBD) and Cannabigerol (CBG), which do not produce a high, could help treat fatty liver disease by improving how the liver regulates energy and maintains cellular balance."
#CBD #CBG #Liver #FattyLiverDisease #LiverFat #Energy #MetabolicHealth #Health

What Your Face May Reveal About Fatty Liver
By: WebMD
BajaPharma
www.facebook.com/BajaPharma

www.facebook.com/photo/?fbid=...

#usa #jacksonville #jacksonvillefl #jacksonvilleflorida #florida #liverdetox #liver #fattyliver #fatty #fattyliverdisease @highlight @everyone @followers @todos

Asha Daryanani, a third-year PhD student and Jason Kim, PhD

Asha Daryanani, a third-year PhD student & member of the Jason Kim lab @umasschan.bsky.social, presented her #research exploring how inflammation contributes to #type2diabetes & #fattyliverdisease. Her data indicate #T2D & #FattyLiver aren't just metabolic conditions but also inflammatory diseases.

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Fatty liver disease is prevalent in Floridians, even if some don’t know it | Column An estimated 100 million Americans are currently living with some form of liver disease.

Fatty liver disease is prevalent in Floridians, even if some don’t know it | Column

www.tampabay.com/viewpoints/2...

#News #USNews #Florida #FloridaNews #Health #PublicHealth #Liver #LiverHealth #LiverDisease #FattyLiverDisease

Mursla Bio partners with global pharma to advance precision medicine in liver disease - PharmaTimes AI platform to support biomarker-guided therapy development in MASH

#hepatology #MurslaBio #precisionmedicine #liverdisease #biomarkerguidedtherapydevelopment #MASH #metabolicdysfunctionassociatedsteatohepatitis #AIPrecisionMedicinePlatform #MEV01clinicalstudy #EvoLiver #biomarkerguidedprecisionmedicine #livercare #fattyliverdisease
zurl.co/ZCOOD

Study in mice reveals long-term metabolic risks of ketogenic diet – BioNews Central A new mouse study suggests the long-term ketogenic diet may harm metabolic health—disrupting fat and carbohydrate processing—and raises concerns about its safety and effectiveness. ...

A new mouse study suggests the #LongTerm #KetogenicDiet may harm #MetabolicHealth—disrupting #fat and #carbohydrate processing—and raises concerns about its #safety and #effectiveness. 
#MetabolicDysfunction #GlucoseIntolerance #FattyLiverDisease

Fatty liver disease, also called hepatic steatosis, happens when too much fat builds up in your liver cells.

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#FattyLiver #LiverHealth #OrganDonationAwareness #TransplantEducation #HealthReels #MedicalFacts #FattyLiverDisease

Scientists Unveil Potential First-of-Its-Kind Treatment for Deadly Fatty Liver Disease A new investigational treatment targets the root cause of a life-threatening liver condition connected to obesity and diabetes, offering hope for millions of patients. Scientists at the University of ...

#Scientists Unveil Potential First-of-Its-Kind #Treatment for Deadly #FattyLiverDisease

scitechdaily.com/scientists-u...

Scientists Unveil Potential First-of-Its-Kind Treatment for Deadly Fatty Liver Disease A new investigational treatment targets the root cause of a life-threatening liver condition connected to obesity and diabetes, offering hope for millions of patients. Scientists at the University of...

Scientists Unveil Potential First-of-Its-Kind Treatment for Deadly Fatty Liver Disease #Science #HealthandMedicine #InfectiousDiseases #FattyLiverDisease #MedicalResearch #HealthInnovation

#Howtoreducecancer 3/5 global liver cancer cases could be prevented by reducing obesity & alcohol intake & increasing hepatitis vaccination. Treatment is difficult. #Livercancer is the 3rd leading cause of cancer death. #Fattyliverdisease is one of the fastest growing causes of liver cancer.

AI detects fatty liver disease with chest X-rays Fatty liver disease, caused by the accumulation of fat in the liver, is estimated to affect one in four people worldwide. If left untreated, it can lead to serious complications, such as cirrhosis and...

🩻 A research group at 🇯🇵 Osaka Metropolitan University developed an #AI model that can detect the presence of hepatic steatosis (fatty liver disease) from chest #Xray images. #FattyLiverDisease

Kupffer cell programming by maternal obesity triggers fatty liver disease - Nature In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.

Cool new story from Elvira Mass lab that position fetal-derived macrophages as critical intergenerational messengers within the concept of developmental origins of health and diseases. #KC #fattyliverdisease @masslab.bsky.social #RTM

www.nature.com/articles/s41...

How maternal obesity also affects the next generation – BioNews Central A study in obese mice found that maternal obesity increases offspring’s risk of fatty liver disease by reprogramming embryonic liver cells and altering metabolism. ...

A study in obese mice found that #MaternalObesity increases offspring’s risk of #FattyLiverDisease by reprogramming embryonic #LiverCells and altering #metabolism
#Obesity #TransgenerationalEffects #MetabolicDisorders

Led by @haohuang0086.bsky.social and Nora R. Balzer
📍 Developmental Biology of the Immune System, LIMES Institute
#DOHaD #macrophages #FattyLiverDisease

Milan Mishkovikj: Ending the Silent Epidemic of Fatty Liver Disease and Addressing Its Deadly Ties to NCDs - OncoDaily Milan Mishkovikj: Ending the Silent Epidemic of Fatty Liver Disease and Addressing Its Deadly Ties to NCDs / cancer, Fatty Liver Day, Fatty Liver Month, Milan

Ending the Silent Epidemic of Fatty Liver Disease and Addressing Its Deadly Ties to NCDs - Milan Mishkovikj
@mkdmilan.bsky.social

oncodaily.com/blog/fatty-l...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #FattyLiverDisease #NCDs #FattyLiverDay #FattyLiverMonth

As a Member of GLI Liver Action Network, we follow #GlobalLiverInstitute’s lead of educating the public with best practices and strategies to improve the lives of those living with #FattyLiverDisease.

Visit globalfattyliverday.com for more information!

#ActNowScreenToday

📣Today is Global #fattyliverday! We are joining Global Liver Institute to raise awareness about #fattyliverdisease in Northeast Ohio. Join us and all our partners around the world as we raise awareness about this serious #liverdisease that is on the rise.

#ActNowScreenToday

GCU Scientists Breakthrough In Liver Cancer Prevention | Glasgow City Of Science & Innovation Glasgow Caledonian University scientists have discovered a new scientific pathway to prevent fatty liver disease, caused by Western diet high in fat and sugar, from progressing to deadly liver cancer.

🍽️ GCU Scientists Make Breakthrough in Fatty Liver Disease Research!

📍 @glasgowcaledonian.bsky.social
👇 Read more

glasgowcityofscienceandinnovation.com/gcu-scientis...

#LiverCancer #FattyLiverDisease #GCUResearch #HealthInnovation #WesternDietRisks #p53 #TIGAR #LifeSciencesScotland

Millions in west do not know they have aggressive fatty liver disease, study says Research finds more than 15m in US, UK, Germany and France with MASH have not been diagnosed More than 15 million people in the US, UK, Germany and France do not know they have the most aggressive form...

Millions in west do not know they have aggressive fatty liver disease, study says #Science #HealthandMedicine #InfectiousDiseases #LiverHealth #FattyLiverDisease #PublicHealth

Fatty liver disease, also called hepatic steatosis, happens when too much fat builds up in your liver cells.

Subscribe to read more on www.pouringpotions.com

#FattyLiver #LiverHealth #OrganDonationAwareness #TransplantEducation #HealthReels #MedicalFacts #FattyLiverDisease

A Study by Lecumberri et al Links Residual Inflammation in #Psoriasis Patients to Obesity and #FattyLiverDisease.
See the full press release here:
ow.ly/KjWw50VWzV3
and full article here:
doi.org/10.1016/j.ji...
@joelgel.bsky.social
#DermatologyJournal #dermatology #dermsky #dermatologists

'Truly miraculous': Common gut microbe shows promise as fatty liver disease treatment Researchers shed light on the

'Truly miraculous': Common gut microbe shows promise as fatty liver disease treatment #Science #HealthandMedicine #InfectiousDiseases #FattyLiverDisease #GutMicrobiome #HealthResearch

FGF21 hormone can reverse fatty liver disease – BioNews Central A pioneering research study details how the hormone FGF21 (fibroblast growth factor 21) can reverse the effects of fatty liver disease in mice. ...

A pioneering research study details how the #hormone #FGF21 (#FibroblastGrowthFactor21) can reverse the effects of #FattyLiverDisease in mice.
#MASLD #MASH