This review highlights #m6A #RNAmodification as a regulator of #RNAmetabolism and cellular processes, linking aberrant m6A to #cancer, #obesity, diabetes, and cardiovascular disease, and exploring m6A-targeted therapies for #MetabolicDisorders.

#OpenAccess: doi.org/10.1016/j.ge...

Dr Srividya Sreekantam, Consultant in Inherited Metabolic Disorders, calls for a more simplistic approach to explaining the biological basis of metabolic disorders. Read more for free in BioNews: www.progress.org.uk/spotting-the...

#MetabolicDisorders #Health #Metabolism #Medicine #DNA

Join us Friday for our February 6th SIMD Fellow Journal Club!

Noon ET

You can register here: tinyurl.com/SIMDJournalC...

#metabolicdisorders

#Inbornerrorsofmetabolism

🌟 Meet Yu-Hsin Chang, young researcher at CNR Naples and part of the EU-funded NutriEV project 🌱
She studies plant-derived #extracellularvesicles for future #nutrition, biosensing & metabolic health.

Read more 👉 nutrievproject.eu/meet-young-r...

#MetabolicDisorders #EICPathfinder

The Role of Adipose Tissue-derived Exosomes in Chronic Metabolic Disorders

This review summarizes the #Biogenesis, components, and uptake of adipose tissue-derived #Exosomes, describing their role in #MetabolicDisorders and clinical applications while discussing current limitations and future therapeutic perspectives. #Medsky

Read: doi.org/10.1007/s115...

Arginase Deficiency Market Size, Share, Trends, Report 2035 Arginase Deficiency Market growth is projected to reach USD 1.466 Billion, at 9.72% CAGR by driving industry size, share, top company analysis, segments research, trends and forecast report 2025 to 20...

Arginase Deficiency Market growth reflects rising awareness and improved metabolic disorder management. www.marketresearchfuture.com/reports/argi... #MetabolicDisorders

Cryo-EM structures of agonist-bound HCAR3-Gi1 and HCAR2-Gi1 complexes. (A) Schematic illustration of agonist selectivity to HCARs. (B-F) Cryo-EM maps and models in cartoon performance of HCAR3-Gi1 complexes in the presence of 6O (B), PLA (C), IBC293 (D), acifran (E), and HCAR2-Gi1 complex in the presence of acifran (F). Agonists are shown in stick representation, and corresponding electron densities are depicted as gray meshes. The maps and structural models are colored by subunits: Pale violet red, 6O-HCAR3; slate blue, PLA-HCAR3; medium sea green, IBC293-HCAR3; dodger blue, acifran-HCAR3; light salmon, acifran-HCAR2; light gray, Gαi; light blue, Gβ; light pink, Gγ; burly wood, scFv16; light green, 6O; cyan, PLA; khaki, IBC293; plum, acifran (HCAR3); medium aquamarine, acifran (HCAR2).

#Hydroxycarboxylic acid receptors HCAR2 & HCAR3 are key targets for treating #MetabolicDisorders. This study reports #cryoEM structures of #HCAR3 with several agonists, informing its ligand recognition & activation mechanism (& HCAR3/HCAR2 differences) @plosbiology.org 🧪 plos.io/48D365m

Cryo-EM structures of agonist-bound HCAR3-Gi1 and HCAR2-Gi1 complexes. (A) Schematic illustration of agonist selectivity to HCARs. (B-F) Cryo-EM maps and models in cartoon performance of HCAR3-Gi1 complexes in the presence of 6O (B), PLA (C), IBC293 (D), acifran (E), and HCAR2-Gi1 complex in the presence of acifran (F). Agonists are shown in stick representation, and corresponding electron densities are depicted as gray meshes. The maps and structural models are colored by subunits: Pale violet red, 6O-HCAR3; slate blue, PLA-HCAR3; medium sea green, IBC293-HCAR3; dodger blue, acifran-HCAR3; light salmon, acifran-HCAR2; light gray, Gαi; light blue, Gβ; light pink, Gγ; burly wood, scFv16; light green, 6O; cyan, PLA; khaki, IBC293; plum, acifran (HCAR3); medium aquamarine, acifran (HCAR2).

#Hydroxycarboxylic acid receptors HCAR2 & HCAR3 are key targets for treating #MetabolicDisorders. This study reports #cryoEM structures of #HCAR3 with several agonists, informing its ligand recognition & activation mechanism (& HCAR3/HCAR2 differences) @plosbiology.org 🧪 plos.io/48D365m

Cryo-EM structures of agonist-bound HCAR3-Gi1 and HCAR2-Gi1 complexes. (A) Schematic illustration of agonist selectivity to HCARs. (B-F) Cryo-EM maps and models in cartoon performance of HCAR3-Gi1 complexes in the presence of 6O (B), PLA (C), IBC293 (D), acifran (E), and HCAR2-Gi1 complex in the presence of acifran (F). Agonists are shown in stick representation, and corresponding electron densities are depicted as gray meshes. The maps and structural models are colored by subunits: Pale violet red, 6O-HCAR3; slate blue, PLA-HCAR3; medium sea green, IBC293-HCAR3; dodger blue, acifran-HCAR3; light salmon, acifran-HCAR2; light gray, Gαi; light blue, Gβ; light pink, Gγ; burly wood, scFv16; light green, 6O; cyan, PLA; khaki, IBC293; plum, acifran (HCAR3); medium aquamarine, acifran (HCAR2).

#Hydroxycarboxylic acid receptors HCAR2 & HCAR3 are key targets for treating #MetabolicDisorders. This study reports #cryoEM structures of #HCAR3 with several agonists, informing its ligand recognition & activation mechanism (& HCAR3/HCAR2 differences) @plosbiology.org 🧪 plos.io/48D365m

Elevated #β2Microglobulin in #hypertrophic #adipocytes activates CD8+ T cells, triggers adipocyte #ferroptosis, and promotes #macrophage M1 polarization, driving obesity-linked #inflammation and #MetabolicDisorders.

#OpenAccess in #STTT: doi.org/10.1038/s413...

ATTENTION!!!!!
The SIMD 2026 ABSTRACT DEADLINE has been EXTENDED to:
December 1, 2025 at midnight Pacific Time
Poster Abstracts, Travel Award Abstracts, Invited Speaker Abstracts, and Satellite Symposium Abstracts.
#SIMD2026
#metabolicdisorders
#inbornerrorsofmetabolism
#inheritedmetabolicdisorders

This study shows that oral NaNO₃ prevents and alleviates #MASLD and #T2DM by rebalancing pro- and anti-inflammatory MoMFs via a sialin-mediated pathway, highlighting its potential for treating #MetabolicDisorders in humans. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

Abstracts are OPEN for #SIMD2026 meeting for our May 2026 Annual Meeting in Puerto Rico! DEADLINE is November 30, 2025 to submit.
More info here:

simd.swoogo.com/2026/

#inbornerrorsofmetabolism
#metabolicdisorders

This Friday, October 3rd at noon ET begins our
2025-2026 SIMD Fellow Journal Club!
Register here to join us:
tinyurl.com/SIMDJournalClub25

#inheritedmetabolicdisorders
#IEMs
#metabolicdisorders
#SIMDJournalClub

This review examines the physiological roles of #Carnosine dipeptidases (CNDPs) in various #Cancers and #MetabolicDisorders, pinpointing CNDPs as an emerging #Diagnostic and #therapeutic tool in #Oncology and #Metabolic conditions. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

SIMD NAMA 2025 Foundations is in full swing at Lanier Islands Lodge in Georgia.
Check back here tomorrow for some Talent Show and Metabolic Jeopardy photos (happening tonight)!

#SIMDNAMA
#NAMAFoundations2025
#InbornErrorsofMetabolism
#MetabolicDisorders

Tiny food particles, big hopes 🌱🧬

Early #NutriEV findings show that plant-derived vesicles may help regulate inflammation & metabolism in mice models — opening new paths to fight #obesity & chronic disease.

Explore our research👉 ibit.ly/C3o21

#Nutrition #MetabolicDisorders #EICPathfinder

This latest article highlights the #physiological role of the CNDP protein family in #Cancer and #MetabolicDisorders, presenting new avenues for the diagnosis and novel #therapeutic strategies for treating various diseases. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

In 2 days – still time to register! Join us Aug 27, 2025 at 11 AM ET on @medliveofficial.bsky.social to learn from #MetabolicDisorders experts on care standards & treatment innovations for #PKU. Gain insights to support long-term Phe control & patient well-being. Register: bit.ly/44EWhzw

Join us Aug. 27, 2025 at 11:00 AM ET on
@medliveofficial.bsky.social to learn from #MetabolicDisorders experts on the latest care standards and treatment innovations for #PKU. Gain insights to support long-term Phe control and patient well-being. Register: bit.ly/44EWhzw #Phenylketonuria #MedEd

Hope for a cure hangs on research Amid drastic proposed cuts to biomedical research, rare disease families like Hailey Adkisson’s fight for survival and hope. Without funding, science can’t “catch up” to help the patients who need it ...

Rare disease research has led to breakthroughs in our understanding of genetics, cell biology, cancer and more.
🔬Meet two families whose stories show why continued research matters more than ever: ow.ly/rMoI50WwubB.
#RareDiseaseResearch #epilepsy #metabolicdisorders #neurosky #neuroskyence

This review explores the biology of #exosomes, the role of adipose tissue-derived exosomes (AT Exos) in various #MetabolicDisorders, and their potential clinical application as #biomarkers and #TherapeuticTargets. @2024HUST

#MostDownloaded: link.springer.com/article/10.1...

Cayman Chemical
In Italia: vb@vincibiochem.it
Discover Cayman products & resources for lipid research in metabolic disorders by visiting our Lipid Resource Center!
➡️https://www.caymanchem.com/lipids/healthanddisease
#lipids #metabolicdisorders #metabolism

🧠 When seizures don’t stop… and the only way to find answers is to shut the brain down.

Subscribe to read more on www.pouringpotions.com

#ChicagoMed #ThiamineMetabolismDisorder #SeizuresInChildren #MedicalReels #HealthAwareness #MetabolicDisorders #VitaminB1Deficiency

How maternal obesity also affects the next generation – BioNews Central A study in obese mice found that maternal obesity increases offspring’s risk of fatty liver disease by reprogramming embryonic liver cells and altering metabolism. ...

A study in obese mice found that #MaternalObesity increases offspring’s risk of #FattyLiverDisease by reprogramming embryonic #LiverCells and altering #metabolism
#Obesity #TransgenerationalEffects #MetabolicDisorders

How do #ExtracellularVesicles influence #Nutrition?🧬

#NutriEVProject is studying how extracellular vesicles from food interact with the gut and immune system—unlocking new tools to fight #obesity and #metabolicdisorders.

Read more 👉🪩 ibit.ly/VXtpY

Ppp1r3b is a metabolic switch that shifts hepatic energy storage from lipid to glycogen PPP1R3B expression determines how hepatic energy is stored and changes contribute to liver damage and metabolic disease.

Discovering molecular lever that controls whether liver stores energy as fat or glycogen. Tuning this switch could open new paths to tackle #MetabolicDisorders. doi.org/10.1126/scia... #Ppp1r3b #HepaticMetabolism #TranslationalScience

🧬 #WorldHormoneDay 2025 – #BecauseHormonesMatter
At #NutriEVProject we're exploringhow nutrient-enriched extracellular vesicles (nutriEVs) from raw & fermented foods may influence hormonal pathways, #metabolicdisorders & gut health.

Read more 🔗 nutrievproject.eu

@esendocrinology.bsky.social

Homeostatic regulation of NAD(H) and NADP(H) in cells

A summary on the physiological roles of NAD(H) & NADP(H) and the mechanisms regulating their homeostasis, including the transcriptional & posttranslational regulation of NADKs, the role of MESH1 & NOCT, & the effect of the #CircadianClock. #MetabolicDisorders

#OpenAccess: buff.ly/qMQOlkh

The debut issue is out now!
👉 academic.oup.com/obendo

@esendocrinology.bsky.social @dr-melania-manco.bsky.social

#obesity #endocrinology #metabolicdisorders