#β2Microglobulin upregulation in #hypertrophic #adipocytes drives CD8+ T cell activation, iron overload, #ferroptosis, and M1 #MacrophagePolarization, while its ablation or knockdown alleviates obesity-linked inflammation and metabolic disorders.

#STTT: doi.org/10.1038/s413...

Elevated #β2Microglobulin in #hypertrophic #adipocytes activates CD8+ T cells, triggers adipocyte #ferroptosis, and promotes #macrophage M1 polarization, driving obesity-linked #inflammation and #MetabolicDisorders.

#OpenAccess in #STTT: doi.org/10.1038/s413...