Metformin in Obese Pregnancy: Developmental Reprogramming of Offspring Liver and MASLD Risk by Age and Sex Abstract. Maternal obesity before and during pregnancy causes maladaptive fetal development with long-term effects on offspring's metabolic health, includi

Metformin in Obese Pregnancy: Developmental Reprogramming of Offspring Liver and MASLD Risk by Age and Sex. Read more in #Endocrinology: bit.ly/4bfBLbZ #MaternalObesity #Metformin #MASLD @endocrinesociety.bsky.social

This review examines the evolution of the gut-placenta axis over the past 50 years and looks forward to its clinical translation in the next 50 years.
doi.org/10.59717/j.x...
#MaternalObesity #gutmicrobiota #placenta

Developmental programming by maternal obesity alters offspring lifespan and immune responses in a diet- and sex-specific manner Maternal obesity is a growing health concern that predisposes offspring to metabolic dysfunction, immune system alterations, and neurodegenerative dis…

1/ 💡We are excited to share our latest paper, continuing our exploration of how maternal obesity programs offspring health via #macrophages - this time using #Drosophila as a model: shorturl.at/28tFo

#MaternalObesity #Drosophila #Neurodegeneration #DOHaD #FlyResearch #MacrophageBiology

How maternal obesity also affects the next generation – BioNews Central A study in obese mice found that maternal obesity increases offspring’s risk of fatty liver disease by reprogramming embryonic liver cells and altering metabolism. ...

A study in obese mice found that #MaternalObesity increases offspring’s risk of #FattyLiverDisease by reprogramming embryonic #LiverCells and altering #metabolism
#Obesity #TransgenerationalEffects #MetabolicDisorders

Paternal Obesity Influences Offspring BMI Trajectory Paternal obesity was associated with rapid BMI growth trajectories among offspring, especially in the presence of maternal obesity.

An elevated paternal #BMI was associated with increased odds of rapid BMI growth trajectories among offspring, especially in combination with #MaternalObesity.

@uoft.bsky.social @ucddublin.bsky.social @ualberta.bsky.social @umanitoba.bsky.social @ubcmedicine.bsky.social

⚡️Shorter telomeres link to aging diseases like heart disease, but mitochondrially-targeted therapeutics (BGP-15, MitoQ, SS-31, metformin) can restore telomere elongation, supporting healthy aging and longevity.

#telomeres #genomicresearch #mitochondrialstress #maternalobesity

𝐖𝐨𝐫𝐥𝐝𝐰𝐢𝐝𝐞 𝐨𝐧𝐞 𝐢𝐧 𝐟𝐢𝐯𝐞 𝐩𝐫𝐞𝐠𝐧𝐚𝐧𝐭 𝐰𝐨𝐦𝐞𝐧 𝐚𝐫𝐞 𝐥𝐢𝐯𝐢𝐧𝐠 𝐰𝐢𝐭𝐡 𝐨𝐛𝐞𝐬𝐢𝐭𝐲 𝐚𝐧𝐝 𝐥𝐨𝐨𝐤𝐬 𝐬𝐞𝐭 𝐭𝐨 𝐫𝐢𝐬𝐞

How big a problem is obesity in pregnancy?

Read this new study from Lisa Kent, Queen's University Belfast

'Global trends in prevalence of maternal overweight and obesity'
ijpds.org/news/15-06-2...

#maternalobesity