Upregulated STIM1 enhances SOCE in #sorafenib-resistant #HCC, activating CaN-NFAT to drive #SLC7A11 transcription, boost GSH, and suppress #ferroptosis; blocking this axis with SKF96365 restores sorafenib sensitivity.
#OpenAccess: doi.org/10.1016/j.ge...
#Research
The role of Nrf2 in anoikis resistance and metastasis in anaplastic thyroid carcinoma doi.org/10.1186/s435...
#ATC #Nrf2 #AnoikisResistance #BCL #SLC7A11 #TherapeuticTarget
This review highlights the role of #SLC7A11 in #Tumorigenesis through modulating ferroptotic responses, emphasizing its potential as a #therapeutic target to suppress #TumorProgression. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
Exploring the role of #SLC7A11 in #cancer! Most read!
This review highlights the pivotal role of #SLC7A11 as a non-conventional checkpoint in the pathogenesis of #cancer, primarily through its regulation of ferroptotic responses under various stress conditions. #medsky
#OpenAccess:
buff.ly/wX2KR3k
Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS-PAGE with low acrylamide concentration
🔗 buff.ly/eNW2ASX
#SLC7A11 #SDSPAGE #ResearchTips
Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis
This review highlights the pivotal role of #SLC7A11 as a non-conventional checkpoint in the pathogenesis of #cancer, primarily through its regulation of ferroptotic responses under a spectrum of stress conditions. #medsky
#OpenAccess: buff.ly/m0wwmiX
Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis
This review highlights the pivotal role of #SLC7A11 as a non-conventional checkpoint in the pathogenesis of cancer, primarily through its regulation of ferroptotic responses under a spectrum of stress conditions.
#OpenAccess: www.sciencedirect.co...
Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis
This review highlights the role of #SLC7A11 as a non-conventional checkpoint in the pathogenesis of cancer, primarily through its regulation of ferroptotic responses under a spectrum of stress conditions. @columbiamed
#OpenAccess: https://buff.ly/4huHr20
