Exciting new project in our lab @babrahaminst.bsky.social! We are working with @alesdantas.bsky.social at @newcastleuni.bsky.social to understand how extrachromosomal circular DNA mediates drug resistance in fungal pathogens
Funded by @wellcometrust.bsky.social
#ecDNA #eccDNA #Candida #Zymoseptoria
Reviewing the #Biogenesis, characteristics, and functions of #eccDNA, and its role in regulating #Tumorigenesis & cancer treatment, with insights into its potential for inspiring precision medicine and identifying #PrognosticBiomarkers.
#OpenAccess: doi.org/10.1016/j.ge...
GBE | Highlight: Running Circles Around Genome Architecture
Our recent Perspective on extrachromosomal circular DNA is the focus of December's GBE Highlight.
Highlight: Running Circles Around Genome Architecture
🔗 doi.org/10.1093/gbe/evaf232
#genome #evolution #eccDNA
1/5: ☺️☺️ Recently, we have published a database paper in the MBE journal @molbioevol.bsky.social titled "eccDNABase: A Comprehensive and High-Quality Database for Extrachromosomal Circular DNA". #eccDNA #disease #multi_species
academic.oup.com/mbe/article/...
📣 New month, new Commentary
Not just a by-product: circular DNA molecules derived from V(D)J recombination are linked to worse prognosis in B-cell leukemia
🔓 buff.ly/hO4fJ9g
🖊️ @andreaventura.bsky.social
#eccDNA #ecDNA
This review highlights the molecular characteristics, biological origins, and advances in detection technologies of #eccDNA, and summarizes their clinical implications in #Cancer diagnosis & prognosis, supporting further exploration of its #Clinical applications. #medsky
buff.ly/VfEzGk3
Studying or interested in #eccDNA, #ecDNA? Join our Extrachromosomal Circular DNA conference, 31 Oct–03 Nov 2025.
Send in an abstract & explore this dynamic & rapidly evolving field with leaders in ecDNA research➡️ bit.ly/3YmCmBY
💸Grants available for ALL career levels
📆Talk submission: 04 Sep 2025
Dynamics and distribution of eccDNA in Arabidopsis. Left: Schematic representation of eccDNA amplification and sequencing via CIDER-Seq pipeline. Top right: EccDNA size distribution in Arabidopsis Col-0 leaf tissues (n = 4,158). The x-axis shows eccDNA size in kb and the y-axis shows the percentage of eccDNAs belonging to each window. Middle right: Size ranges of eccDNAs with marked median and quantiles (n = 4,190). Bottom right: Percentages of eccDNA reads mapping to TAIR CDS, TE, or intergenic databases (values represent the average of three replicates).
Previous studies of extrachromosomal circular DNA #eccDNA in #plants are based on short-read seq. @vanderschuren-lab.bsky.social uses long-read seq to obtain a map of full-length eccDNAs from #Arabidopsis, identifying their genomic origins & epigenetic regulation @plosbiology.org 🧪 plos.io/44Mq3RI
Dynamics and distribution of eccDNA in Arabidopsis. Left: Schematic representation of eccDNA amplification and sequencing via CIDER-Seq pipeline. Top right: EccDNA size distribution in Arabidopsis Col-0 leaf tissues (n = 4,158). The x-axis shows eccDNA size in kb and the y-axis shows the percentage of eccDNAs belonging to each window. Middle right: Size ranges of eccDNAs with marked median and quantiles (n = 4,190). Bottom right: Percentages of eccDNA reads mapping to TAIR CDS, TE, or intergenic databases (values represent the average of three replicates).
Previous studies of extrachromosomal circular DNA #eccDNA in #plants are based on short-read seq. @vanderschuren-lab.bsky.social uses long-read seq to obtain a map of full-length eccDNAs from #Arabidopsis, identifying their genomic origins & epigenetic regulation @plosbiology.org 🧪 plos.io/44Mq3RI
Dynamics and distribution of eccDNA in Arabidopsis. Left: Schematic representation of eccDNA amplification and sequencing via CIDER-Seq pipeline. Top right: EccDNA size distribution in Arabidopsis Col-0 leaf tissues (n = 4,158). The x-axis shows eccDNA size in kb and the y-axis shows the percentage of eccDNAs belonging to each window. Middle right: Size ranges of eccDNAs with marked median and quantiles (n = 4,190). Bottom right: Percentages of eccDNA reads mapping to TAIR CDS, TE, or intergenic databases (values represent the average of three replicates).
Previous studies of extrachromosomal circular DNA #eccDNA in #plants are based on short-read seq. @vanderschuren-lab.bsky.social uses long-read seq to obtain a map of full-length eccDNAs from #Arabidopsis, identifying their genomic origins & epigenetic regulation @plosbiology.org 🧪 plos.io/44Mq3RI
🧬🌟We're excited to add an Extrachromosomal Circular DNA conference to our 2025 calendar!🧬🌟
Chairs Birgitte Regenberg (Univ. of Copenhagen) & Zhao Zhang (Duke Univ.) are bringing a fantastic line up of speakers together in Mexico this year. More details➡️https://bit.ly/4az0PbV #ecDNA25 #eccDNA #ecDNA
