Enterococcus faecalis alters endo-lysosomal trafficking to replicate and persist within mammalian cells Author summary Enterococcus faecalis is often isolated from chronic wounds. Prior to this study, E. faecalis has been observed within different cell types, suggesting that it can successfully colonize...

First, work from @ronni.bsky.social in our group showed E. faecalis can replicate inside macrophages + epithelial cells, and that the intracellularly “trained” population is primed for more efficient reinfection. 2/n #PLOSPathogens @plos.org dx.plos.org/10.1371/jour...

Direct and indirect pathways linking the Lon protease to motility behaviors in the pathogen Pseudomonas aeruginosa Author summary Proteases specifically degrade other proteins inside cells and constitute promising drug targets due to their central roles in cell physiology. In the human pathogen Pseudomonas aerugin...

Direct and indirect pathways linking the Lon protease to motility behaviors in the pathogen Pseudomonas aeruginosa

#PLOSPathogens from @krijonas.bsky.social

journals.plos.org/plospathogen...

Sentinels tracking viruses in various ecosystems: Towards a One Health approach

[ #phimscience ] 📢 New PEARLS in #PLoSPathogens by #LeoBlondet et al 2025 #sentinels 🐜 🐜 🐜 #virosphere 🦠 #OneHealth 🌍 @cirad.bsky.social @ird-fr.bsky.social #UniversitéMarienNgouabi @inrae-france.bsky.social #ArizonaStateUniversity

Leveraging microphysiological systems to expedite understanding of host–parasite interactions Microphysiological systems (MPS) replicate the dynamic interactions between cells, tissues, and fluids. They have emerged as transformative tools for biology and have been increasingly applied to host...

Here’s our latest revision of microphysiological systems in parasitology research, published in @plos.org #plospathogens in collaboration with Jorge de-Carvalho (ITQB-NOVA) and @mariabernabeu.bsky.social. Kudos to @mariazalmeida.bsky.social, PhD student, for the heavy lifting of this work.

Repression of varicella zoster virus gene expression during quiescent infection in the absence of detectable histone deposition Author summary Varicella zoster virus (VZV) establishes latent infection exclusively in human neurons. This phase of infection is characterized by restricted viral gene expression, lack of detectable ...

Happy to share our publication in #PlosPathogens investigating repression of varicella zoster virus in neuron-like cells: journals.plos.org/plospathogen...
Thanks to @dandepledge.bsky.social and other colleagues for their contribution!

The viral origin of myalgic encephalomyelitis/chronic fatigue syndrome

In this article Dr. Maureen Hanson explains why enteroviruses—a group of small RNA viruses which infect the intestine—are the most likely culprits as the cause of #ME.

#EndMalnutritioninME
#PLOSPathogens
journals.plos.org/plospathogen...

The malaria parasite PP1 phosphatase controls the initiation of the egress pathway of asexual blood-stages by regulating the rounding-up of the vacuole Author summary Malaria caused by Plasmodium falciparum infections remains a major human threat in endemic countries. Its proliferation within the host relies on the iteration of red blood cell invasio...

#PLOSPathogens: The #malaria parasite PP1 phosphatase controls the initiation of the egress pathway of asexual blood-stages by regulating the rounding-up of the vacuole dx.plos.org/10.1371/jour... @plos.org ParaFrap Teams: @lebrunlab.bsky.social @lavazeclab.bsky.social

Casein Kinases 2-dependent phosphorylation of the placental ligand VAR2CSA regulates Plasmodium falciparum-infected erythrocytes cytoadhesion Author summary Plasmodium falciparum-infected erythrocytes (IEs) isolated from pregnant women suffering from malaria express at their surface a specific variant of the P. falciparum Erythrocyte Membra...

#PLOSPathogens: Casein Kinases 2-dependent phosphorylation of the placental ligand VAR2CSA regulates Plasmodium falciparum-infected erythrocytes cytoadhesion. (ParaFrap Team: Benoit Gamain) dx.plos.org/10.1371/jour... @plos.org

Modes and mechanisms for the inheritance of mitochondria and plastids in pathogenic protists Pathogenic protists are responsible for many diseases that significantly impact human and animal health across the globe. Almost all protists possess mitochondria or mitochondrion-related organelles, ...

Modes and mechanisms for the inheritance of mitochondria and plastids in pathogenic protists #PLOSPathogens @plos.org
journals.plos.org/plospathogen...

Insights into the origin, hybridisation and adaptation of Candida metapsilosis hybrid pathogens Author summary Yeast pathogens of the Candida genus are estimated to cause almost a million deaths each year globally. Although most infections are caused by the five most common Candida species, the ...

#PLOSPathogens: Insights into the origin, hybridisation and adaptation of Candida metapsilosis hybrid pathoge ... dx.plos.org/10.1371/jour...

Systematic assessment of COVID-19 host genetics using whole genome sequencing data Author summary After infection with SARS-CoV-2, symptoms vary widely. On average, individuals who are older, males and those with certain comorbidities tend to be more severely affected by COVID-19. A...

Happy to share our newest work on #covid19 #hostgenetics ! An analysis of >1000 whole genomes with @kuludwig.bsky.social and Axel Schmidt at University of Bonn and Uniklinik Bonn, the DeCOI consortium and many colleagues from around Germany & beyond. #plospathogens
journals.plos.org/plospathogen...

Cascading expression of ApiAP2 transcription factors controls daughter cell assembly in Toxoplasma gondii Author summary Toxoplasma gondii is a is a unicellular eukaryotic pathogen that infects a wide range of animals. Pathogenesis of this parasite relies on its ability to rapidly proliferate and dissemin...

The best way to start 2025: our latest work is out in #PLOSPathogens. It discusses ApiAP2 transcription factors and daughter cell assembly in T. gondii. A work spearheaded by @be-maanasa.bsky.social with the contribution of @mudiyamv.bsky.social
dx.plos.org/10.1371/jour...

Cellular sialoglycans are differentially required for endosomal and cell-surface entry of SARS-CoV-2 in lung cell lines Author summary The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in over 700 million infections and 7 million deaths so far, demonstrating the threat posed by emerging CoVs. In humans, SARS-Co...

Happy to share our recent paper in #PLOSPathogens where we looked at the roles of sialic acid in the different entry routes of SARS-CoV-2. A great team effort to get this across the finish line! #proudPI
journals.plos.org/plospathogen...

Use of the Puccinia sorghi haustorial transcriptome to identify and characterize AvrRp1-D recognized by the maize Rp1-D resistance protein Author summary The common rust disease of maize is caused by the obligate biotrophic fungus Puccinia sorghi. Resistance to common rust is controlled by race-specific dominant NLR (nucleotide-binding d...

#PLOSPathogens: Use of the Puccinia sorghi haustorial transcriptome to identify and characterize AvrRp1-D rec ... dx.plos.org/10.1371/jour...

Distinct mechanisms of type 3 secretion system recognition control LTB4 synthesis in neutrophils and macrophages Author summary The production of inflammatory lipid mediators by the host is essential for timely inflammation in response to invasion by bacterial pathogens. Therefore, defining how immune cells reco...

Our new manuscript on LTB4 and plague is out in #PLOSPathogens! We used Y. pestis to identify distinct mechanisms of pathogen recognition in leukocytes. Thanks to all our collaborators for much needed help! journals.plos.org/plospathogen...

The figure summarises a series of experiments, showing a fly receiving an initial exposure to and inactivated bacterial pathogen, followed by a live exposure at different time intervals. This is followed by measurements of fly mortality and internal bacterial loads. There are four panels depicting individual experiments using distinct fly genetic backgrounds.

Some exciting work led by former PhD student Arun Prakash, now out in #PLOSPathogens:

IMD-mediated innate immune priming increases #Drosophila survival and reduces pathogen transmission dx.plos.org/10.1371/jour...

Pseudomonas aeruginosa senses and responds to epithelial potassium flux via Kdp operon to promote biofilm

#PLOSPathogens from Jennifer M. Bomberger
with Dominique Limoli @catarmbruster.bsky.social

journals.plos.org/plospathogen...

Crosstalk between circadian clocks and pathogen niche

#PLOSPathogens Review

journals.plos.org/plospathogen...

A conserved switch controls virulence, sporulation, and motility in C. difficile

#PLOSPathogens

journals.plos.org/plospathogen...

Adaptation of the Mycobacterium tuberculosistranscriptome to biofilm growth

#PLOSPathogens from Pepperell Lab

journals.plos.org/plospathogen...

Candida auris undergoes adhesin-dependent and -independent cellular aggregation Author summary Candida auris is a single-celled fungus, a yeast, that can cause severe infections in hospital patients. This fungus is difficult to treat because it is resistant to many antifungal dru...

Let's start my thread with some awesome news: our preprint showing that #CandidaAuris undergoes two genetically separable types of cellular aggregation is out in #PLoSPathogens, we argue that aggregation may help evading the immune system thus causing persistent infections doi.org/10.1371/jour...

Pathogenic #SIRT6 in #Tuberculosis

Mycobacteria⏫Wnt-dep. G9a #HistoneMethyltransferase+#SIRT6 in Mφ->
Cholesterol genes ⏫biosynthesis/uptake ⏬Efflux ->
⏫Mycobacteria antioxidant+survival

G9a inhibitor or Sirt6+/-⏬🐭🫁Granuloma

#PLOSPathogens 2023
journals.plos.org/plospathogen...

Karyotype variation, spontaneous genome rearrangements af... Author summary Strains of the oomycete Phytophthora infes...

Awesome ,novel insights into changes in ploidy in F1 progeny, genome arrangements, and a great genome resource. #PLOSPathogens: Karyotype variation, spontaneous genome rearrangements affecting chemical insensitivity, and ... https://dx.plos.org/10.1371/journal.ppat.1010869

Ferroptosis and microbial pathogenesis Citation: Shen Q, Naqvi NI (2021) Ferroptosis and microbial pathogenesis. PLoS Pathog 17(3): e1009298. https://doi.org/10.1371/journal.ppat.1009298

#PLOSPathogens: Ferroptosis and microbial pathogenesis

dx.plos.org/10.1371/journa…

4/5
Degradation of function of MacAB-TolC efflux pump in African @Salmonella ST313 lineages = convergent evolution

? This new adaptation linked to ability to cause systemic disease #iNTS in immunocompromised people

#PLOSPathogens @LivUni_IVES @LivUni...

Innate immune memory through TLR2 and NOD2 contributes to... Author summary Leptospirosis is a worldwide zoonotic negl...

#PLOSPathogens: Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interroga ... http://dx.plos.org/10.1371/journal.ppat.1007811

Innate immune memory through TLR2 and NOD2 contributes to... Author summary Leptospirosis is a worldwide zoonotic negl...

#PLOSPathogens: Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection http://dx.plos.org/10.1371/journal.ppat.1007811

A streptococcal Fic domain-containing protein disrupts bl... Author summary Streptococcus equi subsp. zooepidemicus (S...

#PLOSPathogens: A streptococcal Fic domain-containing protein disrupts blood-brain barrier integrity by activ ... http://dx.plos.org/10.1371/journal.ppat.1007737

Structural determination of the complement inhibitory dom... Author summary Lyme disease, caused by Borrelia burgdorfe...

#PLOSPathogens: Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes
http://dx.plos.org/10.1371/journal.ppat.1007659

Two Different Virulence-Related Regulatory Pathways in Bo... Author Summary Borrelia burgdorferi, the Lyme disease age...

#PLOSPathogens: Two Different Virulence-Related Regulatory Pathways in Borrelia burgdorferi Are Directly Affected by Osmotic Fluxes in the Blood Meal of Feeding Ixodes Ticks
http://dx.plos.org/10.1371/journal.ppat.1005791