#AJPCellPhys hashtag - Bluesky

@haoyin.bsky.social

4 months ago

#SmoothMuscleCell m6A Epitranscriptomics

METTL14 ⬆️in 🐭 #ThoracicAorticAneurysm (AngII+HFD) or erastin-treated SMC

Liproxstatin-1 or AAV-shMettl14⏬🐭TAA

METTL14-IGF2BP2 stabilizes ACSL4 mRNA➡️
SMC #Ferroptosis

SRAMP➡️m6A site prediction

#AJPCellPhys 2025
journals.physiology.org/doi/full/10....

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Hao Yin

@haoyin.bsky.social

9 months ago

#m6A #SmoothMuscleCell #Ferroptosis #ThoracicAorticAneurysm
#AortaEd

🐭TAA (ANGII+hi cholest diet)➡️
⏫arterial MDA iron
⏬GSH GPX4 SLC7A11
⏫ASCL4
rescued by Liproxstatin-1 or shMETTL14

METTL14/IGF2BP2➡️m6A stabilize ACSL4 mRNA➡️SMC ferroptosis

#AJPCellPhys 2025
journals.physiology.org/doi/full/10....

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Hao Yin

@haoyin.bsky.social

11 months ago

My continued biomedical education
#MASLD #MASH

Pathophysiological underpinnings of metabolic dysfunction-associated steatotic liver disease

Gut (microbiota)-liver axis

#HepaticStellateCell #Pericyte #YAP/TAZ #GLutaminolysis #Fibrosis

#AJPCellPhys 2025
journals.physiology.org/doi/abs/10.1...

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Hao Yin

@haoyin.bsky.social

2 years ago

Itga8-CreERT2 also impacts Bladder #SmoothMuscleCell

Itga8+ SMC #YAP/TAZ KO in Detrusor (8 wks)->
⏬Myocardin+Contractile gene transcription
⏬Rbpms/Rbfox2/Mbnl1->⏬SMC splicing events
Unlike Y/T-KO arterial SMCs, No chondrogenesis

#AJPCellPhys 2023
journals.physiology.org/doi/full/10....

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