#Research
#Hic_5 promotes the progression of #nonalcoholic #steatohepatitis by regulating #hepatocellular fatty acid #metabolism through the #PTEN/PGE2/EP4 axis doi.org/10.1186/s435...

#NonalcoholicSteatohepatitis #HepaticStellateCell #hepatocytes

YAP/TAZ as direct targets of Sirt6 deacetylase

Sirt6 ⏬YAP/TAZ-TEAD1 interaction ⏫VGLL4 (YAP/TAZ suppressor)-TEAD1 interaction

Both Lrat-Cre #HepaticStellateCell & Albumin-Cre Hepatocyte (or leaks to HSC?🤔) Sirt6 KO⏫Liver Fibrosis in MASH🐭

#FASEBJ 2022
faseb.onlinelibrary.wiley.com/doi/10.1096/...

Epithelial membrane protein 1 drives hepatic stellate cell activation via the TLN1/FAK cascade in MASLD donor liver transplantation - Molecular Biomedicine The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) has significantly increased, prompting the increased use of steatotic donor livers in transplantation, contributing t...

#Research
Epithelial membrane protein 1 drives hepatic stellate cell activation via the TLN1/FAK cascade in #MASLD donor liver transplantation doi.org/10.1186/s435...

#Ischemia #reperfusion #injury #LiverTransplantation #HepaticStellateCell #EpithelialMembraneProtein1

#HepaticStellateCell #LiverFibrosis

ISGylation of CREB1 ⏬its transcriptional activation of TGFβ2 & HSC activation

An IFN-IRF9-ISG15 (as intracellular ubiquitin-like protein, not cytokine) cascade

ISG15⬇️ pCREB1⬆️ in fibroblasts & HSCs in 👤cirrhotic liver

#Gut 2025
gut.bmj.com/content/earl...

#DigitalTwin #LiverFibrosis

Simulation of Adjacent Pair of Hexagonal Liver Lobules
Hepatocyte
#HepaticStellateCell
Mφ
Sinusoid scaffold
Collagen matrix

Fibrotic wall formation from mechanical compression of Cycles of hepatocytic death-proliferation

bioRxiv 2025
www.biorxiv.org/content/10.1...

MicroRNAs in Liver Fibrosis: Unraveling Intercellular Crosstalk and the Regulatory Functions of MicroRNA-223 Announcing a new article publication for BIO Integration journal. Liver fibrosis is caused by excessive extracellular matrix accumulation, which in turn is driven by activation of hepatic stellate cel...

This commentary summarizes the mechanistic functions of microRNA-223 (#miR223) in #HepaticStellateCell activation and #fibrosis, discusses its #therapeuticpotential and highlights it as a complex but intriguing target for #antifibrotic treatment.

#OpenAccess: bio-integration.org/micrornas-li...

My continued biomedical education
#MASLD #MASH

Pathophysiological underpinnings of metabolic dysfunction-associated steatotic liver disease

Gut (microbiota)-liver axis

#HepaticStellateCell #Pericyte #YAP/TAZ #GLutaminolysis #Fibrosis

#AJPCellPhys 2025
journals.physiology.org/doi/abs/10.1...

Ohh😀
Sirtuin 6 protects against hepatic fibrogenesis by suppressing the YAP and TAZ function

LRAT+ #HepaticStellateCell Sirt6 KO-> increased TGFβ-SMAD3 + #YAP/TAZ activity

Similar or opposite in SMC?

#FASEBJ 2022
faseb.onlinelibrary.wiley.com/doi/full/10....