New research finds even occasional heavy drinking — just once a month — may raise the risk of serious liver scarring, even in otherwise moderate drinkers.
youtu.be/94DhGD7llUk

#LiverHealth #FattyLiver #LiverDisease #LiverFibrosis #BingeDrinking #HeavyDrinking

Two graphs compare significant fibrosis in overall & steatosis populations, plotting odds ratio (OR) with 95% confidence intervals. X-axis shows CMRF risk factors: Obesity, High WC, HTN, GI, HTG, Low HDL, CMRF@2. Men & Women are represented in blue and orange. P values shown.

Among US adults, women with central adiposity, glucose intolerance, or ≥2 #Cardiometabolic risk factors had a greater increase in odds of significant #LiverFibrosis compared with men.

ja.ma/3MWLL0F

Traditional Chinese Compound Gandouling May Reverse Liver Fibrosis in Wilson Disease A compound used in traditional Chinese medicine inhibits the sinusoid capillarization associated with liver fibrosis in Wilson disease, a study shows.

#Gandouling may inhibit #LiverFibrosis in #WilsonDisease by severing the cellular communication between hepatic stellate cells and sinusoidal endothelial cells and preventing sinusoid capillarization. Study in Pharmaceuticals.

Read more: https://bit.ly/4r3UyN0

#RareDisease #MedSky

From hypoxia to hepatic injury: obstructive sleep apnea as a driver of liver fibrosis Obstructive sleep apnea (OSA) and nonalcoholic fatty liver disease (NAFLD) represent two increasing global health epidemics, often coexisting and sharing c

The health impacts of #ObstructiveSleepApnea (OSA) are wide in scope. This article explores the role #OSA might have on the pathology of #liverfibrosis.  academic.oup.com/sleep/articl...

KLF4 Inhibits the Activation of Human Hepatic Stellate Cell In Vitro

KLF4 suppresses HSC activation!
Researchers show #KLF4 maintains quiescence in #HepaticStellateCells by inhibiting proliferation and activation, suggesting it as a potential therapeutic target for preventing and reversing #LiverFibrosis.
Read: doi.org/10.1007/s115...

Association between Serum Ferritin Levels and Metabolic-associated Fatty Liver Disease in Adults: a Cross-sectional Study Based on the NHANES

Elevated #SerumFerritin is strongly associated with #MAFLD and advanced #LiverFibrosis, independent of iron intake; combined with #diabetes, it poses major risk, highlighting #ferritin as a #biomarker and therapeutic target.

Read: doi.org/10.1007/s115...

⭐ The EP300/YAP1-SERPINE1 pathway promotes liver fibrosis (LF) in biliary atresia (BA) by regulating ductular reaction. Inhibiting EP300 reduces LF in BA models, providing a novel therapy strategy.
🔗 https://ow.ly/eNK650Y0pIM
🏷️ #GIHealth #LiverFibrosis

FAPI-PET shows promise in patients with liver fibrosis The technique outperformed standard blood-based and ultrasound exams.

In an analysis of 14 patients, the technique performed better than standard ultrasound and blood-based diagnostic methods #radiology #ultrasound #FAPIPET #liverfibrosis buff.ly/tUlGxJW

Lipotoxicity-induced miR-34a mediates communication driving liver fibrosis.
#LiverFibrosis #MicroRNA #Inflammation #HepaticStellateCells #Lipotoxicity
www.sciencedirect.com/science/arti...

#Targetome
Silybin + carvedilol combo shows powerful synergistic effects against liver fibrosis by inhibiting Wnt4/β-catenin signaling in activated hepatic stellate cells! 🧬💊
Details: www.maxapress.com/article/doi/10.48130/tar...
#liverfibrosis #effect #combo

Unexpected Drug Combo Reverses Liver Fibrosis A new drug combination shows unexpected synergy against liver fibrosis. A new study reveals that using two drugs together produces a much stronger effect than using either one alone, suggesting a real...

Unexpected #Drug Combo Reverses #LiverFibrosis

scitechdaily.com/unexpected-d...

New preclinical data from Arnatar’s ACT-UP1 platform will be presented at @asnkidney.bsky.social’s #KidneyWeek25 (Nov 5–9, Houston) & @aasldnews.bsky.social’s #LiverMeeting25 (Nov 7–11, DC). Exploring novel RNA therapies for #ADPKD, #LiverFibrosis & #ALGS.

🧬 www.arnatar.com/news/arnatar...

For #LiverAwarenessMonth, let's take a look at a study that found adipose tissue macrophage-derived sEVs promote liver fibrosis in obesity via pro-fibrogenic miRNAs.
Read it here: 🔗 ow.ly/Wx9550XcMkB
#LiverFibrosis #MASH #sEVs #miRNAs

Review article examines regulation of hepatic stellate cell phenotypes in metabolic dysfunction–associated steatohepatitis.
🔗 ow.ly/Szwr50X3Bt4
#LiverFibrosis #MALSD

#HepaticStellateCell #LiverFibrosis

ISGylation of CREB1 ⏬its transcriptional activation of TGFβ2 & HSC activation

An IFN-IRF9-ISG15 (as intracellular ubiquitin-like protein, not cytokine) cascade

ISG15⬇️ pCREB1⬆️ in fibroblasts & HSCs in 👤cirrhotic liver

#Gut 2025
gut.bmj.com/content/earl...

New severity scores help non-invasively assess liver disease in pediatric GSD IX, while #liverbiopsy remains key for understanding fibrosis and guiding care. bit.ly/3VB0IpO #GIMO #GlycogenStorageDiseaseTypeIX #LiverDiseaseScoring #LiverFibrosis #LiverDiseaseSeverity

AI Model Improves Liver Fibrosis Staging with Missing MRI Data

The adapted mmFormer model achieves accuracies of 66.67% for cirrhosis detection and 74.17% for substantial fibrosis on the CARE 2025 challenge, even with missing MRI sequences. Read more: getnews.me/ai-model-improves-liver-... #liverfibrosis #mmformer

#DigitalTwin #LiverFibrosis

Simulation of Adjacent Pair of Hexagonal Liver Lobules
Hepatocyte
#HepaticStellateCell
Mφ
Sinusoid scaffold
Collagen matrix

Fibrotic wall formation from mechanical compression of Cycles of hepatocytic death-proliferation

bioRxiv 2025
www.biorxiv.org/content/10.1...

Ground breaking liver disease screening study reaches 2000 patients The Early Detection of Liver Disease research project (ID LIVER) takes a targeted and streamlined approach to identifying, assessing and managing patients at increased risk of liver disease in underse...

Hard miles done by colleague Steph Landi to push ID LIVER recruitment >2,400 👏 #liverbsky

🖥️ ML2 paper in the pipeline - developing a #machinelearning model to detect #liverfibrosis at population level

manchester.ac.uk/about/news/ground-breaking-liver-disease-screening-study-reaches-2000-patients/

NEWS You Might Have Missed
@fibrosisvalencia2025
@liver.health_
@liverhealthmd
@liver_healthcare
#liver #liverhealth #liverfibrosis #mmj #mmjpatient #healthcare #education #community #care #usa #healthnews #health #patient #patientcare

AI‐Assisted Drug Re‐Purposing for Human Liver Fibrosis A multi-agent AI (AI co-scientist) is used to repurpose drugs for liver fibrosis treatment and to guide their experimental characterization. The anti-fibrotic efficacy and toxicity of these drugs is ...

Do we already have the drugs we need for the diseases at hand and is #AI the key to finding these hidden gems?
A paper published in #AdvancedScience demonstrates that a "AI co-scientist" can guide the repurposing of drugs for #liverfibrosis.

advanced.onlinelibrary.wiley.com/doi/10.1002/...

Host FSTL1 defines the impact of stem cell therapy on liver fibrosis by potentiating the early recruitment of inflammatory macrophages - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Host FSTL1 defines the impact of stem cell therapy on liver fibrosis by potentiating the early recruitment of inflammatory macrophages

FSTL1 promotes early macrophage recruitment to facilitate stem cell therapy and, therefore, could serve as a predictive #biomarker of stem cell therapy response in patients with #LiverCirrhosis. #LiverFibrosis #medsky

#STTT #OpenAccess:

Role of mac-2 binding protein glycosylation isomer in predicting fibrosis in patients with metabolic dysfunction-associated steatotic liver disease.
Ho, Dat Tan, Nguyen, Dang et al.
Paper
Details
#LiverFibrosis #Mac2ProteinGlycosylation #MetabolicDysfunctionSteatosis

Check out my new @epigenometech.bsky.social blog article on how single-cell gene expression and epigenetic profiling may offer a way forward for liver fibrosis treatment.

#EpigenomeTech #LiverFibrosis #SingleCell #Multimodal

The interplay between biomechanics and cell kinetics explains the spatial pattern in liver fibrosis
Bode, J., Buttenschoen, A. et al.
Paper
Details
#LiverFibrosis #BiomechanicsCellKinetics #BodeButtenschoenResearch

MASLD Rates Decreasing, Fibrosis and Cirrhosis Rates Increasing in T2D in US MASLD rates have decreased, whereas liver fibrosis and cirrhosis rates have increased among US patients with type 2 diabetes since 2017.

The prevalence of #MASLD has decreased, whereas the prevalence of #LiverFibrosis and #cirrhosis have increased among US patients with #T2D since 2017.

@endocrinesociety.bsky.social

This study reveals that elevated #serumferritin levels are associated with a higher prevalence of #MAFLD and advanced #liverfibrosis and their combination with #diabetes significantly increases the risk of liver fibrosis. #NHANES #MostDownloaded #medsky

Read: link.springer.com/article/10.1...

#MPS2025 – Final Day!
Finishing off a great week with a presentation on our automated liver fibrosis assay on a lobule-structured microfluidic model—designed for predictive, high-throughput screening.

📄 Download the poster: shorturl.at/qVGZH
#LiverFibrosis #OrganOnAChip #DrugDiscovery

New data from Dr. Naglaa Shoukry at CRCHUM found that treating mice with the RORγt inhibitors TF-S10 and TF-S14 developed by Dr. Jean Tchervenkov at @mcgilluniversity.bsky.social. These results open the door for new therapeutics to treat #LiverFibrosis. Read more in #AAInews: ow.ly/38GS50W6VSQ.

Scientists at the University of Sunderland have created two experimental drugs that block the enzyme HDAC6, showing hope in stopping or reversing liver fibrosis, a condition that often develops without symptoms and currently has no cure.

#LiverFibrosis #MedicalResearch #HDAC6 #LiverHealth