Hepatoprotective Ergostane and Lanostane Derivatives from Mushrooms for the Management of Metabolic Dysfunction−Associated Fatty Liver Disease: A Review

dl.begellhouse.com/journals/708...

#MAFLD #MedicinalMushrooms #NaturalProducts

so now we get to the second main question around Fatty Liver Disease, aka MAFLD:

what causes it?

that is a simple question with a somewhat complicated answer

#NEISvoid
#MAFLD

That's how the liver's backup battery is supposed to work

But if you have Fatty Liver Disease (aka Metabolic Associated Fatty Liver Disease or MAFLD)

the liver keeps adding to the battery backup store of energy, and also reduces how much energy it actually sends to the brain

#NEISvoid
#MAFLD

annoyed about the shitty "patient education" I received when I was initially diagnosed with Fatty Liver Disease

so rather than seething, I'm going to share some of the info I've gotten from reading scientific articles

#NEISvoid
#MAFLD

Our article on plasma fatty acid composition, oxidative stress, inflammation, and adherence to the Mediterranean diet in MAFLD patients continues to gain impact: 3,141 views 📈
🔗 www.mdpi.com/2076-3921/12...
#MedDiet #MAFLD #Antioxidants #OxidativeStress #Inflammation #MDPI

Association between Serum Ferritin Levels and Metabolic-associated Fatty Liver Disease in Adults: a Cross-sectional Study Based on the NHANES

Elevated #SerumFerritin is strongly associated with #MAFLD and advanced #LiverFibrosis, independent of iron intake; combined with #diabetes, it poses major risk, highlighting #ferritin as a #biomarker and therapeutic target.

Read: doi.org/10.1007/s115...

This review outlines the pathophysiology of #MAFLD, highlighting critical transcription factors as potential drug targets to prevent disease progression by modulating #HepaticSteatosis and #Fibrosis. @fudan-university.bsky.social

#OpenAccess: doi.org/10.1016/j.ge...

Transcription factors play key roles in metabolic dysfunction–associated fatty liver disease (MAFLD), driving inflammation, fibrosis, and metabolic imbalance while pointing to new therapeutic options.
#MAFLD #TranscriptionFactors #Metabolism #Inflammation
www.sciencedirect.com/science/arti...

📈 Meta-analysis confirms: ⬆️ serum uric acid (SUA) levels are ➕ linked to ⬆️ risk of MAFLD.
🧪 SUA may serve as a biomarker — and even a therapeutic target — in MAFLD mgmt

#MAFLD #Hepat #EBM
Read in #JGIM: rdcu.be/eKohC

お口の健康が脂肪肝のリスクを減少させる可能性についての最新研究 サンスターと自治医科大学の共同研究により、お口の健康が脂肪肝リスクを低下させることが示されました。しっかり噛めることの重要性に迫ります。

お口の健康が脂肪肝のリスクを減少させる可能性についての最新研究 #サンスター #MAFLD #口腔健康

サンスターと自治医科大学の共同研究により、お口の健康が脂肪肝リスクを低下させることが示されました。しっかり噛めることの重要性に迫ります。

🧬 Machine learning cracks the code on fatty liver disease! Qiao et al. reveal 5 game-changing genes that could transform diagnosis & treatment. 🔬 Precision medicine just got smarter! #Genomics #MedicalBreakthrough #MAFLD https://emmecola.github.io/genomics-daily

Congratulations: The "Guideline for the Prevention and Treatment of Metabolic Dysfunction-associated Fatty Liver Disease (Version 2024) " #MAFLD #NAFLD #NASH has been recognized as a 2025 hot paper by WOS. As of now, it has garnered 21 citations in the WOS.

www.xiahepublishing.com/2310-8819/JC...

Multiomics reveals metformin’s dual role in gut microbiome remodeling and hepatic metabolic reprogramming for MAFLD intervention - Scientific Reports Scientific Reports - Multiomics reveals metformin’s dual role in gut microbiome remodeling and hepatic metabolic reprogramming for MAFLD intervention

A new study shows metformin benefits MAFLD by remodelling the gut microbiome and reprogramming liver metabolism—highlighting its dual role in tackling this liver disease. Published in Scientific Reports. #Metformin #MAFLD #Microbiome #Metabolism #Research

www.nature.com/articles/s41...

This study reveals that elevated #serumferritin levels are associated with a higher prevalence of #MAFLD and advanced #liverfibrosis and their combination with #diabetes significantly increases the risk of liver fibrosis. #NHANES #MostDownloaded #medsky

Read: link.springer.com/article/10.1...

✨ Gut Fungus to the Rescue, The Surprising Natural Ally Against Fatty Liver Disease! Discover how a powerful gut fungus, Fusarium foetens, is shaking up the fight against fatty liver disease! 🌱 Learn how scientists are tapping into the gut's "dark matter" for breakthrough natural trea...

✨ Gut Fungus to the Rescue, The Surprising Natural Ally Against Fatty Liver Disease!

#FattyLiverCure #MAFLD #MASH #GutHealing #GutHealthMatters #LiverSupport #HolisticMedicine #ProbioticPower #FungalTherapy #MicrobiomeMiracle #NaturalHealing

ultimatehealingsolutions.com/2025/06/05/%...

Prevalencia de hepatopatía grasa asociada a disfunción metabólica es alta en niños y adolescentes con obesidad grave, caracterizada por una resistencia a la insulina más elevada y un mayor número de componentes del síndrome metabólico #MAFLD #children #obesity www.mdpi.com/3319632

HLF and PPARα axis regulates metabolic‐associated fatty liver disease through extracellular vesicles derived from the intestinal microbiota The specific knockout of intestinal hepatic leukemia factor (HLF) improved metabolic-associated fatty liver disease (MAFLD) by inhibiting peroxisome proliferator-activated receptor alpha (PPARα) and ...

HLF and PPARα axis regulates #metabolic‐associated fatty #liver disease through extracellular vesicles derived from the intestinal #microbiota onlinelibrary.wiley.com/doi/full/10.... #MAFLD #microbiome #medtwitter

🌟 Congrats to Arifur Rahman!

3rd at WSU's Grad Symposium for his AI study on PNPLA3 mutants in liver disease. Co-mentored by WSU EACPHS Pharm. Sci. faculty, Drs. Zhengping Yi & Wanqing Liu.

🔗 #WayneStateResearch #MAFLD #AcademicExcellence

Serum lactate dehydrogenase is a novel predictor for the severity in t | DMSO Assessing the association between the level of lactate dehydrogenaseand the severity of metabolic syndrome and Metabolic Associated Fatty Liver Disease

Niveles elevados de LDH se asocian con la presencia y gravedad del síndrome metabólico y hepatopatía grasa asociada con el metabolismo, por lo que podría usarse como biomarcador de estas alteraciones metabólicas #MAFLD. MetS #LDH www.dovepress.com/serum-lactat...

#Mitochondrial targeted therapy in #MAFLD
www.sciencedirect.com/science/arti...

And the Australian 🇦🇺 #MAFLD guidelines (disclaimer: I am not an author) were endorsed by all these societies who are key players, especially primary care (college of general practice).

Metabolic dysfunction-associated fatty liver disease (MAFLD) Consensus Statement

Yes, I have been following this from Day 0. Just when I thought it is all over, I saw our society GESA released primary guidelines for #MAFLD #liversky
@ebtapper.bsky.social

www.gesa.org.au/resources/cl...

The biggest problem with attempting to recover from Non-Alcohol Liver Disease #MAFLD #NAFLD is a healthy liver is required to filter crap from the blood to allow nutrient and drug absorption. The second problem is a healthy pancreas & kidneys are essential but kidneys take the longest to recover.

Liver-to-Aorta communication😎
#Atheroasclerosis #MAFLD #MedialArterialCalcification

Steatotic Liver-derived #ExtracellularVesicle
⏫atherosclerotic lesion +calcification
⏫MAFLD-associated arterial calcification
⏫Osteogenesis of #SmoothMuscleCell

#AdvSci 2024
onlinelibrary.wiley.com/doi/10.1002/...

Register by Jan. 8th (11:59pm MST) to save $200 and attend 2 conferences for the price of one! Join us in Feb. in Banff, Canada for the Obesity and Adipose Tissue / Mash meeting. Visit keysym.us/KSObesity25 or keysym.us/KSMASH25 to secure your spot. #KSMASH25 #KSObesity25 #MASH #MAFLD #liverfibrosis

Divergent roles of RIPK3 and MLKL in high-fat diet–induced obesity and MAFLD in mice Cell death frequently occurs in the pathogenesis of obesity and metabolic dysfunction–associated fatty liver disease (MAFLD). However, the exact contribution of core cell death machinery to disease ma...

Hi bluesky, just wanted to share our most recent paper from the
@katelawlorlab.bsky.social showing distinct roles for #necroptosis effectors RIPK3 (+ Caspase-8) that drives inflammation, and MLKL which regulates lipid handling in obesity-induced #MAFLD. www.life-science-alliance.org/content/8/1/...

Join our joint meeting on Obesity & Adipose Tissue / MASH! Submit abstracts for short talks by 11:59 PM MST, December 4th. Visit hubs.la/Q02Z4Jlq0 or hubs.la/Q02Z4G770.
.
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#KSObesity25 #KSMASH25 #obesity #adipose #adiposetissue #adipocyte #metabolicdisease #MASH #NASH #NAFLD #MAFLD #fibrosis

#MAFLD is exploding in Asia says Prof. Jacob George @APASLnews plenary. Children also have the highest prevalence anywhere in the world.
@MAIDEN_MAFLD initiative created to drive the science and engagement #LiverTwitter

It’s a full house for the @APASLnews PGC on #MAFLD #MASH
Take homes:
✅ MAFLD & NAFLD mostly the same in AP area & MAFLD may identify more persons with fibrosis
✅ MAFLD may enhance ability to identify #HCC
✅ MAFLD predicts #ASCVD better than NAFLD
#livertwitter

@EASLnews @AASLDtweets #NAFLD or #MAFLD. Whatever you do, please don’t leave us #BAFLD #livertwitter