Xia & He Publishing doi:

🧠 Triplicated DYRK1A may be a major driver of impaired neurogenesis and cognitive deficits in Down syndrome, keeping DYRK1A inhibitors in focus. @megeblad.bsky.social
#DownSyndrome
🔗 www.xiahepublishing.com/1555-3884/GE...

Perioperative Anaphylaxis: Etiology, Pathophysiology, Diagnostic Challenges, Immediate Management, Prevention Strategies, and Future Perspectives Perioperative anaphylaxis is a rare, life-threatening, iatrogenic condition that predominantly arises following anesthesia. The unique context of this condition, characterized by the concurrent administration of multiple drugs, patient draping, and altered physiological states, presents significant diagnostic and therapeutic challenges, contributing to a higher mortality rate compared to anaphylaxis in other settings. This narrative review synthesizes the evidence to delineate the evolving etiology, pathophysiology, atypical clinical presentation, evidence-based immediate management, and strategic prevention of perioperative anaphylactic reactions. The primary causative agents include neuromuscular blocking agents, antibiotics, and latex, with emerging culprits such as chlorhexidine, dyes, and novel agents like remimazolam. Diagnosis is complicated by the paucity of cutaneous signs; thus, cardiovascular collapse combined with a low end-tidal carbon dioxide level has emerged as a useful supportive diagnostic indicator that requires integration with the clinical context. Immediate management prioritizes the prompt administration of epinephrine and aggressive fluid resuscitation. Subsequent allergological investigations, primarily via skin testing and serum tryptase/histamine measurement, are paramount for identifying the causative agent and preventing its recurrence. Prevention strategies emphasize meticulous history-taking, risk stratification, and the creation of latex-free environments. Future directions must focus on establishing global surveillance networks, exploring novel biomarkers and risk factors such as the circulating microbiome—a preliminary but promising area of research—and enhancing team preparedness through simulation training to improve patient safety outcomes.

🔬 Perioperative anaphylaxis is fast, dangerous, and still difficult to diagnose. This review centers immediate management, prevention, and surveillance. @nejm.org
#Anaphylaxis
🔗 www.xiahepublishing.com/2472-0712/ER...

Traditional Chinese Medicine in Febrile Neutropenia Treatment: Advances and Prospects Febrile neutropenia (FN) is one of the acute and serious complications of chemotherapy-induced myelosuppression in tumor patients. Antibiotics and granulocyte colony-stimulating factor are the mainstays of its treatment. However, this therapy still faces many challenges and may trigger drug resistance, as well as adverse effects such as bone pain and vasculitis. How to minimize treatment-related toxicity while ensuring therapeutic efficacy has become a key issue to be addressed in current clinical practice. In recent years, traditional Chinese medicine (TCM) has demonstrated unique advantages in the prevention and treatment of FN. We conducted a comprehensive search of the PubMed, Web of Science, and CNKI databases using keywords such as TCM and FN, covering the period from their establishment to May 2025. Clinical studies have shown that the combination of TCM and modern medicine can significantly reduce the incidence of FN, while also enhancing the number of granulocytes, shortening the duration of fever, improving the quality of life of patients, and reducing other toxic effects of chemotherapy. These results suggest that TCM is a promising and safe complementary therapy. However, more high-quality trials are needed to verify its benefits. This review summarizes the latest progress in the treatment of FN with TCM and discusses future development directions.

🌿 TCM may offer supportive value in febrile neutropenia by helping ease toxicity and resistance pressures tied to standard care. @helloeacr.bsky.social
#FebrileNeutropenia
🔗 www.xiahepublishing.com/2835-6357/FI...

Characteristic Genomic and Clinicopathologic Landscape of DNA Polymerase Epsilon Mutant Colorectal Adenocarcinomas – A Retrospective Cohort Study DNA polymerase epsilon catalytic subunit A (POLE) gene plays a crucial role in DNA repair and chromosomal replication. Mutations in the POLE gene have been linked to cancer, particularly colorectal carcinoma (CRC). However, the genomic landscape and pathological significance of POLE mutant CRC remain underreported. This study aimed to characterize the clinicopathologic features and genomic landscape of CRC harboring POLE mutations and to investigate the implications of co-occurring genetic alterations.

🎯 POLE-mutant colorectal adenocarcinomas show a distinct genomic landscape, and co-mutations in DNA repair genes may help explain their heavy mutational load. @ascocancer.bsky.social
#ColorectalCancer
🔗 www.xiahepublishing.com/2771-165X/JC...

Pitfalls in the Diagnosis of Celiac Disease: Bridging Gaps from Serology to Clinical Practice Celiac disease is a chronic, immune-mediated enteropathy precipitated by gluten exposure in genetically predisposed individuals, with a global prevalence of approximately 1%. Though diagnostic workflows incorporate serologic techniques with both histologic and genetic evaluation, each approach carries key pitfalls that contribute to diagnostic inaccuracy. Serology testing is limited by selective immunoglobulin A deficiency and low-titer antibodies, in addition to interlaboratory variability of calibration standards and specimen concentrations. While duodenal biopsy is considered the gold standard for celiac diagnosis, patchy villous atrophy (e.g., ultrashort celiac disease) mimics other enteropathies, and the inherent subjectivity of histologic interpretation can compromise accuracy. Furthermore, celiac predisposition is highly correlated with two human leukocyte antigen (HLA) alleles, HLA-DQ2 and HLA-DQ8. However, nearly 30–40% of the general population expresses one of these alleles, thus introducing the risk of overdiagnosis and limiting the practical implications of genetic testing. There exist special celiac presentations, such as seronegative or potential celiac disease, overlap syndromes, and enteropathy-associated T-cell lymphoma, that introduce additional challenges to diagnostic success. The serologic-histologic discordance and nonspecific symptoms associated with these cases may require divergence from the traditional workflow, as well as supplemental investigations, such as a gluten challenge or breath testing, to confirm a celiac diagnosis. These challenges in celiac diagnosis have driven research into novel biomarkers and molecular assays that can not only enable earlier, more accurate detection but also provide longitudinal disease monitoring. Such markers include intestinal fatty acid-binding proteins, specific microRNA expression, and microbiome signatures that are strongly linked to celiac disease, which may one day serve as adjunctive screening tools to optimize diagnostic yield. This narrative review identifies the key pitfalls in adult celiac disease diagnosis — from pre-analytic serology issues to patchy histology and overinterpretation of HLA — and proposes a guideline-aligned, stepwise algorithm (with emerging biomarkers) to enhance accuracy and reduce missed or delayed cases. Ultimately, continued refinement of a comprehensive, multimodal diagnostic strategy that can integrate with emerging molecular tools is necessary for overcoming the current limitations of individual approaches to celiac diagnosis.

🩺 Celiac diagnosis still has traps: test while patients are on gluten, check total IgA, biopsy the bulb, and don’t overread HLA. @amcollegegastro.bsky.social
#CeliacDisease
🔗 www.xiahepublishing.com/2994-8754/JT...

The Role of the Brain-lymphatic Axis in Traumatic Brain Injury-associated Cognitive Impairment: From Glymphatic System Clearance Dysfunction to Peripheral Lymphatic Stasis Traumatic brain injury (TBI)-associated cognitive impairment is highly prevalent, severely impacting patients’ daily life and social functioning, with its mechanisms incompletely understood. Globally, TBI affects over 69 million people annually, and post-TBI cognitive impairment may last for years, or even a lifetime, imposing heavy burdens on patients’ families. The brain-lymphatic axis (glymphatic + peripheral lymphatic systems, especially meningeal vessels) has gained attention: glymphatic dysfunction (dependent on astrocyte endfeet Aquaporin-4 polarization, key for clearing β-amyloid and other wastes) causes metabolic waste accumulation and neuroinflammation, while peripheral lymphatic stasis worsens cognitive decline. This review aims to summarize their roles, dissect mechanisms, and outline therapies. The review found that most current studies explore the glymphatic system and the peripheral lymphatic system in isolation, lacking understanding of their dynamic interplay (e.g., bidirectional inflammatory factor transmission, immune cell migration, synergistic dysfunction); longitudinal studies that track axis changes across TBI stages (acute, subacute, chronic) are scarce; diagnostic tools are insufficient (non-invasive biomarkers lack large-scale clinical validation, and imaging has limited clinical use); and existing therapeutic strategies mostly target single subsystems, with few combined interventions for the whole axis. In conclusion, this review highlights critical gaps in current knowledge and proposes integrated, axis-targeted approaches as a promising direction for future research and therapeutic development.

🤖 The brain-lymphatic axis may be central to post-TBI cognitive impairment, linking glymphatic failure with peripheral lymphatic stasis. @dukeneurosurgery.bsky.social
#TraumaticBrainInjury
🔗 www.xiahepublishing.com/3067-6150/NS...

Global Burden and Trends of Cervical Cancer in Spain Based on GBD 2023 The other formula used for DALYs is DALY = years of life lost + years lived with disability.

📊 Spain’s cervical cancer burden fell markedly from 1990 to 2023, reinforcing the population-level value of HPV vaccination plus organized screening. @trevorgraham.bsky.social
#HPVVaccination
🔗 www.xiahepublishing.com/2835-3315/CS...

Obstructive Sleep Apnea and Lung Cancer: Epidemiological Insights and Pathophysiological Mechanisms Obstructive sleep apnea (OSA) is a prevalent sleep disorder characterized by intermittent hypoxia and sleep fragmentation, which may contribute to lung cancer development and progression. This review synthesizes epidemiological evidence on the association between OSA and lung cancer incidence and mortality, highlighting inconsistencies due to study design, population differences, and confounding factors such as smoking and obesity. While some studies report an increased lung cancer risk, particularly with severe nocturnal hypoxemia, others suggest no significant association or a potential protective effect. Pathophysiologically, OSA promotes oncogenesis through hypoxia-inducible factor activation, tumor immune microenvironment remodeling, exosome-mediated signaling, nuclear factor κB pathway activation, and enhanced cancer stem cell properties. Continuous positive airway pressure therapy may mitigate these effects, with evidence suggesting reduced lung cancer incidence and improved prognosis in adherent patients. This review underscores the need for standardized studies using objective diagnostics and robust confounder adjustment to clarify the OSA–lung cancer link and optimize clinical management.

🔬 Could obstructive sleep apnea help fuel lung cancer biology? The epidemiology is mixed, but intermittent hypoxia remains a key mechanistic clue. @jackwestmd.bsky.social
#SleepApnea
🔗 www.xiahepublishing.com/2472-0712/ER...

Expert Consensus on Physician–Pharmacist Co-management Model and Standardized Application of Anti-IgE Monoclonal Antibody Therapy for Allergic Asthma This Consensus aims to establish a physician–pharmacist co-management model to standardize the rational clinical application of anti-immunoglobulin E monoclonal antibodies in the treatment of allergic asthma. Focusing on the critical components of physician–pharmacist co-management, key issues related to anti-immunoglobulin E monoclonal antibody therapy were identified through a systematic literature review and clinical practice experience. Evidence quality was evaluated using an evidence grading system, and the Delphi method was applied to reach expert consensus. Centered on omalizumab, the Consensus presents 12 recommendations covering the work model of physician–pharmacist co-management, clinical management pathways, hierarchical diagnosis and treatment systems, as well as training and competency assessment. The Delphi process achieved a high degree of consensus (agreement >80%) on 12 key recommendations, emphasizing a 60-min observation period post-injection and quarterly follow-up evaluations. It establishes a standardized framework for the co-management of omalizumab therapy in allergic asthma. Results highlighted that co-management effectively monitors omalizumab dosage (75–600 mg) and maintains a consensus threshold of >80% for patient safety protocols. The Consensus provides a standardized framework for physician–pharmacist co-management, which is expected to facilitate rational drug use and improve patient care pathways in omalizumab therapy.

🩺 An expert consensus outlines physician-pharmacist co-management and standardized anti-IgE therapy use for allergic asthma. @nejm.org
#Asthma
🔗 www.xiahepublishing.com/2572-5505/JE...

Two Different Somatic-type Malignancies Arising from a Mediastinal Germ Cell Tumor: A Case Report Mediastinal germ cell tumors (GCTs) are rare malignant neoplasms that occasionally develop somatic-type malignancies (SMs), such as sarcomas, carcinomas, and hematologic malignancies.

🧫 Two different somatic-type malignancies arising from one mediastinal germ cell tumor underline just how aggressive and complex these cases can be. @mdanderson.bsky.social
#Pathology
🔗 www.xiahepublishing.com/2771-165X/JC...

Xia & He Publishing doi:

🔬 A systems-level RAAS network analysis highlighted IL6, EDN1, TNFA, MK01, LEP, and JUN as key nodes-and mapped 10 candidate transcription factors. @mikefeigin.bsky.social
#GeneNetworks
🔗 www.xiahepublishing.com/1555-3884/GE...

High Rate of Positive Fecal Occult Blood Test in Healthy Infants: A Nested Case-control Study Guaiac fecal occult blood test (gFOBT) is often used to evaluate evidence of food protein-induced allergic proctocolitis (FPIAP) in children in primary care and gastroenterology settings; however, it has not been validated for this diagnosis, and little is known about the positivity rates in early infancy. In this study, we used samples from healthy asymptomatic infants aged two weeks to two months to evaluate the gFOBT positivity rate compared to those diagnosed with FPIAP.

🩺 Healthy infants can have positive fecal occult blood tests too, so gFOBT alone may overcall infant FPIAP. A useful caution for everyday practice. @gastroenterology.bsky.social
#InfantGIHealth
🔗 www.xiahepublishing.com/2994-8754/JT...

Helicobacter pylori and Gastric Cancer: A Potential New Paradigm of 3R (Remove, Remodel, Repair) Integrated Therapy Based on Nanomaterials Helicobacter pylori infection represents a significant modifiable risk factor in the pathogenesis of gastric cancer. Nevertheless, conventional antibiotic treatments have increasingly proven inadequate due to challenges such as antibiotic resistance, microbial dysbiosis, and mucosal damage. In response to these issues, this review introduces an innovative intervention strategy based on the “nanotechnology-based 3R” approach (Remove H. pylori, Remodel the microenvironment, Repair the gastrointestinal tract), which aims to offer a comprehensive solution for managing H. pylori infection. This strategy comprises three principal components. Firstly, the utilization of pH/light/magnetic multi-responsive nanomaterials facilitates the precise eradication of the pathogen and its biofilm. Secondly, to address bacterial immune evasion, these nanomaterials are engineered to target and neutralize virulence factors such as VacA, thereby contributing to the reversal of the local immunosuppressive environment. Thirdly, the utilization of nanomaterials presents a promising approach for the concurrent repair of the mucosal barrier and the maintenance of intestinal microbiome homeostasis. Finally, this paper provides a comprehensive analysis of the specific mechanisms employed by typical nanomaterials, including metal-organic frameworks, charge-reversal nanoparticles, nanozymes, and antimicrobial peptide crystals. These mechanisms involve targeted microbial eradication, activation of autophagy, and the upregulation of tight junction proteins. Furthermore, the study delves into the critical roles played by multimodal external field stimulation and material–host interaction network analysis, which are essential for future clinical translation. Ultimately, this review suggests a potential roadmap for system-precision intervention that transcends the conventional “sterilization first” paradigm. Nonetheless, the current evidence regarding the efficacy and safety of this approach is predominantly derived from cell and mouse models. Therefore, its clinical applicability requires validation through studies involving large animal models and prospective clinical trials.

🔬 Beyond antibiotics, this review proposes a 3R nanomaterial strategy for H. pylori and gastric cancer: remove, remodel, repair. @tmprowell.bsky.social
#Nanomedicine
🔗 www.xiahepublishing.com/2835-3315/CS...

Molecular Docking of Resveratrol with Ovarian Cancer-associated Proteins and Its Therapeutic Benefits Ovarian cancer (OC) is a major global health problem. The main treatments are surgery and chemoradiotherapy. A drawback of the latter is that repeated treatments are likely to lead to cancer cells developing resistance to the drug, resulting in recurrence, development of metastases, and poor prognosis for patients. Consequently, there is interest in combining chemoradiotherapy with treatment using active components extracted from natural products. One such component is resveratrol (RVT), which is a natural anti-tumor ingredient extracted from plants. Although there are many reviews on the biological activity of RVT, only a few studies have been performed to investigate the diversity of protein binding of RVT with OC and the application of various novel drug formulations containing RVT to treat OC. The review presented here may provide some ideas for the prevention and treatment of OC.

🎯 Molecular docking highlights resveratrol interactions with ovarian cancer-associated proteins, supporting its interest as a complementary antitumor lead. @mdanderson.bsky.social
#OvarianCancer
🔗 www.xiahepublishing.com/2835-6357/FI...

Therapeutic Potential of Withania somnifera (L.) Dunal (Ashwagandha) in Neuronal Plasticity and Recovery after Stroke The incidence and mortality of stroke are gradually increasing. In this context, post-stroke neuronal loss and the related long-term complications, along with costly treatment strategies, are significant concerns for healthcare professionals, and effective, convenient, and inexpensive therapeutic modalities are required. Natural and easily accessible herbal remedies may be the optimal option in post-stroke recovery. This narrative review aims to summarize the neuroprotective properties of Withania somnifera (Ashwagandha) and its therapeutic efficacy in neuronal plasticity and recovery after stroke. Original research articles, reviews, and case studies were sourced from databases such as PubMed, Web of Science, Scopus, Google Scholar, Medline, and Embase. Only full articles published in English up to July 2025 were considered. Keywords including W. somnifera, Ashwagandha, stroke, cerebral ischemia, neurodegeneration, neuronal loss, and post-stroke recovery were utilized for the literature search. It has been found that various plant parts of W. somnifera are abundant in bioactive compounds. The neuroprotective effects of W. somnifera are documented in numerous diseases. Nevertheless, W. somnifera is reported to be involved in modulating various biological pathways to mitigate neuroinflammation, apoptosis, and oxidative stress in stroke. W. somnifera promotes cell proliferation and enhances neurogenesis. Preclinical experiments on murine models show the effectiveness of W. somnifera in post-stroke recovery by enhancing neural plasticity and reducing neuronal loss in the infarct area. Furthermore, W. somnifera boosts neurotransmitter levels, improves motor functions, and enhances memory. It also decreases neutrophil infiltration in the infarct region and lessens neuronal loss. Therefore, the application of W. somnifera may prove advantageous in facilitating post-stroke recovery by enhancing neural function. However, well-designed clinical trials are needed to confirm the efficacy of W. somnifera in post-stroke recovery in humans.

🧠 Ashwagandha may support recovery after stroke by reducing neuroinflammation, oxidative stress, and apoptosis while promoting plasticity in preclinical models. @dukeneurosurgery.bsky.social
#StrokeRecovery
🔗 www.xiahepublishing.com/2472-0712/ER...

Beyond Monotherapy: Why Antimicrobial Synergy Demands a Renaissance of Combinatorial Thinking In this editorial, “traditional frameworks” refers to the holistic and multi-component therapeutic paradigms embedded within medical systems such as Ayurveda (India), Kampo (Japan), traditional Chinese medicine (TCM; China), Unani and Kabiraji medicine (Bangladesh), and Jamu (Indonesia). These systems are historically grounded in multi-component therapeutic reasoning rather than single-agent potency. This editorial is not a response to a specific article but a topical editorial addressing the broader conceptual and translational evolution of antimicrobial synergy. By framing synergy within the context of systems pharmacology and multi-agent therapeutics, I aim to encourage renewed dialogue on how interaction-based strategies can inform the next generation of antimicrobial research and policy.

🧫 Why chase monotherapy alone? This piece argues antimicrobial synergy deserves a comeback in the era of resistance. @uwidfellowship.bsky.social
#AntimicrobialSynergy
🔗 www.xiahepublishing.com/2572-5505/JE...

An Infantile Low-grade Mesenchymal Tumor with Fibrohistiocytic Differentiation and Co-occurring CSF1R Mutation and MALAT1 Rearrangement The tumor cells exhibited strong positivity for CD163 (a), approximately 40% positivity for Cyclin D1 (b), and a Ki-67 proliferation index of approximately 40% in hotspot regions (h). Staining results were negative for ERG (c), WT1 (d), MPO (e), NKX2.2 (f), and CD117 (g).

🧫 A rare infantile low-grade mesenchymal tumor with CSF1R mutation and MALAT1 rearrangement expands the molecular map of pediatric soft tissue tumors. @icr.ac.uk
#PediatricPathology
🔗 www.xiahepublishing.com/2771-165X/JC...

Micro- and Nanoplastics: A Paradigm Shift in the Pathogenesis of Inflammatory Bowel Disease Micro- and nanoplastics (MNPs) are pervasive environmental contaminants with growing recognition as potential contributors to human disease. Widespread human exposure occurs primarily through ingestion of contaminated food and water, and MNPs have been detected in multiple human tissues, including the gastrointestinal tract. Experimental evidence provides a plausible biological basis for disease associations, including impairment of intestinal barrier integrity, activation of mucosal immune pathways, and alteration of gut microbial communities caused by MNP exposure. Although human data remain limited, early studies demonstrate MNP detection in stool and suggest potential correlations with inflammatory biomarkers such as fecal calprotectin. These findings, together with mechanistic data from in vitro and animal models, raise concern that MNP exposure represents a paradigm shift in the pathogenesis or modulation of inflammatory bowel disease (IBD); however, methodological variability, small sample sizes, and contamination challenges currently limit definitive conclusions. The aim of this review is to evaluate the current understanding of MNP exposure and its impact on intestinal health, particularly in relation to IBD. We synthesize mechanistic and early clinical evidence linking MNPs to IBD and highlight critical research gaps. Future standardized exposure assessment, mechanistic validation in human systems, and longitudinal studies are essential to clarify causal relationships. Given the modifiable nature of environmental plastic exposure, advancing this field may offer new opportunities for IBD prevention and intervention.

🩺 Could micro- and nanoplastics be part of the IBD story? This review links them to barrier injury, immune shifts, and microbiome disruption. @amergastroassn.bsky.social
#IBD
🔗 www.xiahepublishing.com/2994-8754/JT...

Development and Successful Treatment of Spinal Mixed Histiocytosis in an Elderly Woman following Two Relapses of BRAF-mutated Unifocal Skull Langerhans Cell Histiocytosis Development of mixed histiocytosis (Langerhans cell histiocytosis (LCH))/Erdheim–Chester disease (ECD)) after treatment in patients with an initial skull LCH lesion has not been well recognized. An elderly woman initially developed LCH at the left temporal bone, preceded by polyuria and polydipsia five years earlier; the lesion was surgically removed. Two years thereafter, she experienced her first LCH relapse with a right parietal skull lesion, in which a BRAF V600E mutation was confirmed, and chemotherapy was initiated. After a second LCH relapse involving the left parietal bone, the patient presented with a third relapse at the L2 vertebra. This lesion was pathologically diagnosed as mixed histiocytosis (LCH/ECD), resulting in refractoriness to conventional chemotherapy, and was successfully treated with targeted therapy using BRAF and MEK inhibitors. Spinal mixed histiocytosis (LCH/ECD) may develop following relapses of skull LCH after chemotherapy, for which targeted therapy could be effective.

🎗️ After relapsed skull LCH, a spinal mixed histiocytosis case achieved remission with BRAF and MEK inhibitors-highlighting the value of PET/CT and genetic workup. @mdanderson.bsky.social
#PrecisionOncology
🔗 www.xiahepublishing.com/2996-3427/On...

Integrating Multiomics and Whole Slide Imaging for Predicting the Malignant Transformation of Precancerous Rectal Lesions Predicting the malignant transformation of rectal precancerous lesions remains challenging because conventional Whole Slide Images (WSIs) capture morphological information but lack molecular insight. Multiomics data provide complementary biological signals that often precede visible morphological changes. This study aimed to develop an artificial intelligence (AI)-based multimodal framework integrating WSI and multiomics data for accurate early prediction of malignant transformation.

🎯 Can we predict which precancerous rectal lesions will turn malignant? Multiomics plus whole-slide imaging may move that goal closer. @oncodaily.bsky.social
#CancerPreventionAI
🔗 www.xiahepublishing.com/2835-3315/CS...

In vitro Antibacterial Activity of Crude Extracts from Tithonia diversifolia (Asteraceae) and Solanum torvum (Solanaceae) against Selected Shigella Species Infectious diarrhea is a gastrointestinal illness that results in around 1.7 billion cases and 525,000 deaths annually, particularly among children under five, according to the World Health Organization. While some Cameroonian medicinal plants show promise for treating diarrhea, many plants are used without established scientific evidence of their efficacy. These plants include Tithonia diversifolia (T. diversifolia) and Solanum torvum (S. torvum), which are traditionally used to treat diarrheal symptoms. This study sought to investigate the anti-Shigella activity of leaf extracts from T. diversifolia and S. torvum.

🔬 Crude extracts from Tithonia diversifolia and Solanum torvum showed antibacterial activity against selected Shigella species in vitro. @uwidfellowship.bsky.social
#AntimicrobialResistance
🔗 www.xiahepublishing.com/2572-5505/JE...

Xia & He Publishing doi:

🎗️ 2.3 THz radiation reshaped purine metabolism and membrane raft signaling in human melanoma cells in this metabolomic and gene-network analysis. @mmalumbres.bsky.social
#Melanoma
🔗 www.xiahepublishing.com/1555-3884/GE...

The Epigenetic–Metabolic Axis in Gliomas: Mechanisms and Implications Gliomas remain a major challenge in brain cancer treatment. Although genetic mutations have been widely studied, recent research indicates that epigenetic changes, which alter gene activity without changing the DNA sequence, also contribute significantly to tumor growth and treatment resistance. This review seeks to elucidate the principal drivers and modulators of brain tumor development, emphasizing the complex interaction between tumor metabolism and epigenetic regulation. It highlights how metabolic intermediates influence chromatin structure and transcriptional events driving glioma progression. Metabolic intermediates, such as acetyl-CoA and S-adenosylmethionine, serve as essential epigenetic cofactors, directly impacting chromatin structure and gene expression. Additionally, metabolic disorders like diabetes not only frequently coexist with gliomas but also exacerbate tumor progression through mechanisms such as inflammation, oxidative stress, and epigenetic reprogramming. Tumors located near brain regions controlling heart function may also increase the risk of sudden death, particularly in diabetic patients. The review proposes a comprehensive framework to understand glioma development by linking metabolism, epigenetics, and overall health. This integrated perspective leads to novel personalized treatment approaches, targeting both the tumor and the patient’s broader metabolic health, with the potential to improve survival rates and quality of life for glioma patients.

🔬 In gliomas, metabolism and epigenetics are tightly entwined. This review maps how that axis shapes progression and therapeutic opportunity. @eanoassociation.bsky.social
#Glioma
🔗 www.xiahepublishing.com/2472-0712/ER...

A Systematic Review of Medicinal Plants with Anti-Entamoeba histolytica Activity: Phytochemistry, Efficacy, and Clinical Potential Amoebiasis, or amoebic dysentery, is a gastrointestinal disorder caused by the parasite Entamoeba histolytica. The disease is endemic in parts of Africa, Asia, North and South America, leading to several deaths annually. Reported adverse effects associated with the current first-line treatment for amoebiasis, coupled with the evolution of resistance to it, call for the need to search for plant-based alternatives. This study systematically reviews medicinal plants with activity against Entamoeba histolytica.

🔬 Plant-based anti-Entamoeba histolytica therapies deserve closer attention as resistance and adverse effects keep limiting current amoebiasis treatment. @uwidfellowship.bsky.social
#Amoebiasis
🔗 www.xiahepublishing.com/2835-6357/FI...

Weakly Supervised Teacher–Student Framework with Progressive Pseudo-mask Refinement for Gland Segmentation Colorectal cancer histopathological grading relies on the accurate segmentation of glandular structures. Current deep learning–based methods depend heavily on large-scale pixel-level annotations that are labor-intensive and not amenable to clinical practice. Weakly supervised semantic segmentation offers a promising alternative; yet, existing class activation map–based weakly supervised semantic segmentation approaches often produce incomplete, low-quality pseudo-masks that overemphasize discriminative regions and fail to provide reliable supervision for unannotated glandular structures, limiting their suitability for dense histopathology segmentation under sparse supervision. We propose a novel weakly supervised teacher–student framework that leverages sparse pathologists’ annotations and an Exponential Moving Average–stabilized teacher network to generate refined pseudo-masks.

🧫 A weakly supervised teacher-student framework pushed gland segmentation forward with limited annotations-good news for scalable pathology AI. @cancerresearchuk.org
#ComputationalPathology
🔗 www.xiahepublishing.com/2771-165X/JC...

Optimizing Bowel Preparation in High-risk Patients Undergoing Colonoscopy: A Narrative Review Identifying patients at high risk for poor bowel preparation preceding a colonoscopy is critical to successful colorectal cancer screening. High-risk patients, such as those who are obese, diabetic, opioid users, or former smokers, often have comorbidity, medication, and sociodemographic factors that lead to suboptimal bowel preparation even when following protocol. Suboptimal preparation results in missed lesions, longer procedure times, and increased healthcare costs. Optimal visualization of the colon mucosa is achieved through effective bowel preparation. Polyethylene glycol (PEG) solutions are preferred for their safety, especially in patients with kidney or cardiac disease. Split-dose PEG regimens with a low-residue diet are recommended by the American Gastroenterological Association to promote cleansing and patient tolerance. Tailored regimens can be employed in high-risk patients, including those with chronic constipation, opioid dependence, or diabetes. Educational interventions, such as written and verbal instructions, patient navigators, and mobile device reminders, improve compliance. Medical strategies include split-dose PEG-electrolyte lavage solution with bisacodyl, additional purgatives for select patients, and avoidance of sodium phosphate in elderly or renally impaired individuals. Open-access colonoscopy services have expanded following the COVID-19 pandemic to manage backlogs and improve access. Improving education, simplifying regimens, and targeting interventions can reduce repeat procedures and enhance colorectal cancer detection. This narrative review summarizes patient-, medication-, and system-level risk factors for inadequate bowel preparation in high-risk populations and synthesizes practical, evidence-based strategies to optimize colonoscopy quality, including in open-access settings.

🩺 Better bowel prep starts with better tailoring: split-dose PEG, low-residue diet, and clear patient education can improve colonoscopy quality in high-risk groups. @esge-news.bsky.social
#Colonoscopy
🔗 www.xiahepublishing.com/2994-8754/JT...

Protection against Endothelial Injury Mediates the Anti-thrombotic Effect of Danggui Buxue Decoction in a Rat Model of Cirrhotic Portal Vein Thrombosis PVT is a harmful event in cirrhosis, and the prevention and treatment of PVT are important in the management of cirrhosis and portal hypertension. The study aimed to observe the efficacy of Danggui Buxue Decoction (DBD) on portal vein thrombosis (PVT) in cirrhosis and to elucidate the related mechanism using a modified animal model.

🩺 Danggui Buxue Decoction reduced thrombosis in a rat model of cirrhotic portal vein thrombosis, with endothelial protection as a key mechanism. @aasldnews.bsky.social
#PortalVeinThrombosis
🔗 www.xiahepublishing.com/2703-173X/GH...

Evaluation of Target Irregularity as a Potential Parameter in Gamma Knife Treatment Planning: A Retrospective Cross-sectional Study in Vestibular Schwannoma Fast inverse planning in radiosurgery planning is limited by an excessive number of isocenters, which is clinically hypothesized to be driven by the morphological irregularity of the target volume. This retrospective cross-sectional study aimed to empirically evaluate this hypothesis in vestibular schwannoma cases.

🧠 Could target irregularity explain why fast inverse planning creates so many isocenters? This study tests that idea in vestibular schwannoma radiosurgery. @barany-society.bsky.social
#VestibularSchwannoma
🔗 www.xiahepublishing.com/3067-6150/NS...

Curcumin as a Chemotherapy Compound for Treatment of Breast Cancer: A Review Breast cancer (BCA) is one of the most common cancers worldwide, with a high rate of incidence and mortality. This review provides global information on BCA therapy using curcumin. Chemotherapy, as an effective treatment for different stages of BCA, and curcumin, generally regarded as safe compound and an alternative to synthetic drugs, have been described for the treatment of BCA. A few parameters, including nano-curcumin versus bulk curcumin and its encapsulated form versus its corresponding free form, have been discussed. Curcumin, a safe and edible compound with antitumor properties, is a promising medicinal compound for the treatment of BCA. Encapsulation of curcumin enhances its stability and anticancer efficiency. Nano-curcumin exhibits superior properties when compared to its bulk counterparts, leading to notable interactions and effects.

🎯 Curcumin keeps drawing attention in breast cancer research, and nano-formulations may help solve long-standing stability and delivery issues. @erikahamilton9.bsky.social
#BreastCancer
🔗 www.xiahepublishing.com/2835-3315/CS...

The Oncodarwinian Hypothesis: Cancer as a Potential Immunoadaptive Response and Artificial Intelligence-based 3D Printed p53 Superproteins This review presents the Oncodarwinian Hypothesis, which proposes a new medical paradigm: that of cancer as a potential macro-immunoadaptive response (susceptible to fine-tuning or reprogramming/management via artificial intelligence-based 3D printed p53 superproteins). A traditional hypothesis-generation method was adopted; it entails observing a biophenomenon longitudinally (tumor-precursor out-of-control cell division), formulating and refining targeted research questions, and then, rooted in a prior interdisciplinary theoretical framework, outlining (per deductive reasoning) a testable answer or statement apt to predict outcomes. Two main theoretical findings emerge from this review: the plausibility of a wireless p53 superprotein molecular biochip (3D printed) and cancer cells’ dual-focus immunological nature. It will be necessary to approach the key issue and prognosis of (supposedly meaningless) uncontrolled cell division in a different light. Basically, the same diseasing cancer also constitutes a self-replicating immunoadaptive algorithm that needs to be deciphered. An interdisciplinary quest to unravel its “source code” involves genomic palaeontology and learning the natural selection programming language — for developing (personalized) artificial intelligence-assisted p53 superproteins.

🎯 What if cancer can sometimes be viewed through an immunoadaptive lens? This hypothesis pushes a provocative rethink of tumor biology. @jung-sillah.bsky.social
#CancerBiology
🔗 www.xiahepublishing.com/2472-0712/ER...