KLF4 Inhibits the Activation of Human Hepatic Stellate Cell In Vitro

KLF4 suppresses HSC activation!
Researchers show #KLF4 maintains quiescence in #HepaticStellateCells by inhibiting proliferation and activation, suggesting it as a potential therapeutic target for preventing and reversing #LiverFibrosis.
Read: doi.org/10.1007/s115...

Sentrin‐specific protease 3 (SENP3)-mediated Krüppel-like factor 4 (KLF4) deSUMOylation regulates vascular smooth muscle cell phenotypic switching in atherosclerosis - Molecular Biomedicine Phenotypic switching of vascular smooth muscle cells (VSMCs) from a contractile toward a synthetic phenotype plays a critical role in atherosclerosis. Although the redox-sensitive sentrin/Small Ubiqui...

#Research
Sentrin‐specific protease 3 (SENP3)-mediated Krüppel-like factor 4 (KLF4) deSUMOylation regulates vascular smooth muscle cell phenotypic switching in atherosclerosis doi.org/10.1186/s435...

#SENP3 #KLF4 #SUMOylation #PhenotypicSwitching #Atherosclerosis

Mechanistically, we find that #KLF4 is key, driving a shift from basal-like to hillock-like states. Our findings shed light on how cancer progression mirrors normal tissue development. We hope this work paves the way for cell state-specific therapies for #squamous lung cancer.