can enrich for this #hillock-like state. We identify surface markers that can be explored as ways to target the hillock-like state, which we think will be important to fully eradicate #squamous cancers. A companion manuscript identified #Tmprss11b as a #KLF4-regulated hillock gene impacting the TME.

KLF4 promotes a KRT13+ hillock-like state in squamous lung cancer - PubMed Lung squamous cell carcinoma (LUSC) is basal-like subtype of lung cancer with limited treatment options. While prior studies have identified tumor-propagating cell states in squamous tumors, the broader landscape of intra-tumoral heterogeneity within LUSC remains poorly understood. Here, we employ S …

Transcriptional plasticity is a major barrier to effective cancer treatment. We know a lot about it in #SCLC but less is known for #squamous #lungcancer. Luke Izzo & Tony Reyes have made major inroads into this problem in our latest preprint:
pubmed.ncbi.nlm.nih.gov/40161723/

The sunscreen scandal shocking Australia - the world's skin cancer capital It has shaken consumer trust and raised questions about global sunscreen regulation.

Alarming…
#melanoma #basal #squamous #cell #carcinoma #skin #cancer #dermatology #australia

www.bbc.com/news/article...

The oncologist told me that he does not think there might be a metastasis based on my intermittent mild pain in the nose. I wonder if there are good biomarkers of #HPV-associated #squamous cell #cancer of the nasal vestibule.

Looking for the latest info about mets squamous cell skin cancer.

Who is doing the most innovative protocols with the least amount of side effects - specially around shrinking a tumor ahead of surgery + immunotherapy?
#squamous #cancer

Mechanistically, we find that #KLF4 is key, driving a shift from basal-like to hillock-like states. Our findings shed light on how cancer progression mirrors normal tissue development. We hope this work paves the way for cell state-specific therapies for #squamous lung cancer.

Schematic showing single cell RNA-seq from human squamous tumors, mouse models and tumor organoids. A second graphic shows a model of squamous lung cancer heterogeneity where KLF4 promotes basal cells to adopt a KRT13+ hillock-like state.

#Squamous #lungcancer cells aren’t all alike — the tumor is a mix of distinct cancer cell states! @lukeizzo.bsky.social & Oliver lab uncover #KRT13+ hillock-like, slow-dividing, immunomodulatory tumor cells that resemble the recently discovered normal lung #hillock cells (Lin et al, Nature, 2024).

POGOPHAGE (Monday lunchtime motion sketch 💀) #monster #animation #encounter #dungeoncrawl #rpg #squamous #aftereffects #ae #design #illustration #film

Perineural Invasion Is Associated With Function-evoked Pain and Altered Extracellular Matrix in Patients With Head and Neck Squamous Cell Carcinoma Head and neck squamous cell carcinoma (HNSCC) is painful, and perineural invasion (PNI) has been associated with the worst pain. Pain due to HNSCC is …

Perineural Invasion Is Associated With function-evoked #pain and altered extracellular matrix in #patients with head and neck #squamous cell carcinoma 🔬 #cancerpain #Perineuralinvasion #HNSCC #FunctionevokedPain www.sciencedirect.com/science/arti...

The Long Night- A Dwarf Fortress mod by Squamous.

This is the commercial that I made for it in my last CoQ episode. This is what i'm doing now I guess.

Long Night mod on Steam: steamcommunity.com/sharedfiles/...

#commercial #90s #DwarfFortress #mod #squamous #radical #TheLongNight #Longnight

Prof. Neil Gross #Surgical #oncology expert @mdanderson.bsky.social talks Future of surg onc & data/role for #neoadjuvant #immunotherapy for #squamous cell #carcinoma #SCC / post Tx cheek tumor was mostly scab/Only 5mm viable tu #Bridge2024 @sitcancer.bsky.social #FinishCancer