SENP3 Promotes Mantle Cell Lymphoma Development through Regulating Wnt10a Expression

This study shows #SENP3 upregulation drives #MantleCellLymphoma progression—its knockdown inhibits proliferation, induces #apoptosis, suppresses Wnt/Wnt10a signaling, and limits #tumor growth, highlighting SENP3 as a promising #TherapeuticTarget.
Read: doi.org/10.1007/s115...

Sentrin‐specific protease 3 (SENP3)-mediated Krüppel-like factor 4 (KLF4) deSUMOylation regulates vascular smooth muscle cell phenotypic switching in atherosclerosis - Molecular Biomedicine Phenotypic switching of vascular smooth muscle cells (VSMCs) from a contractile toward a synthetic phenotype plays a critical role in atherosclerosis. Although the redox-sensitive sentrin/Small Ubiqui...

#Research
Sentrin‐specific protease 3 (SENP3)-mediated Krüppel-like factor 4 (KLF4) deSUMOylation regulates vascular smooth muscle cell phenotypic switching in atherosclerosis doi.org/10.1186/s435...

#SENP3 #KLF4 #SUMOylation #PhenotypicSwitching #Atherosclerosis