Dysregulated #glutaminolysis promotes #aging by activating a CASTOR1-mediated arginine–mTORC1 pathway, linking glutamine catabolism to #senescence and highlighting metabolic control of glutaminolysis as a promising strategy to delay aging.

#OpenAccess #STTT: doi.org/10.1038/s413...

This study shows that CD28–PI3K signaling suppresses PANK4 via #PDK1 to control de novo lipid synthesis, and Pank4 deletion boosts CoA synthesis, #glutaminolysis, and CD4⁺ T-cell proliferation. #TCellImmunity #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

Landmark revisit
#Glutaminolysis #Glutaminase1 #GLS1 #Angiogenesis

Glutamine fuels proliferation but not migration of endothelial cells
www.embopress.org/doi/full/10....

Role of glutamine and interlinked asparagine metabolism in vessel formation
www.embopress.org/doi/full/10....

Migration or not🤓

My continued biomedical education
#MASLD #MASH

Pathophysiological underpinnings of metabolic dysfunction-associated steatotic liver disease

Gut (microbiota)-liver axis

#HepaticStellateCell #Pericyte #YAP/TAZ #GLutaminolysis #Fibrosis

#AJPCellPhys 2025
journals.physiology.org/doi/abs/10.1...