This recent study identifies #PDK1 as a key regulator of #EGFR-#TKIresistance and points to emerging potential #Biomarkers and #TherapeuticTargets that could redefine strategies to overcome resistance in #LungCancer. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

This study shows that CD28–PI3K signaling suppresses PANK4 via #PDK1 to control de novo lipid synthesis, and Pank4 deletion boosts CoA synthesis, #glutaminolysis, and CD4⁺ T-cell proliferation. #TCellImmunity #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α

This study shows that #PDK1 plays a key role in enhancing the protein stability and transcriptional activity of #Hypoxiainduciblefactor1α (HIF-1α), and together, PDK1 and HIF-1α form a positive feedback loop that promotes #BreastCancer progression. #medsky

#OpenAccess:www.sciencedirect.co...