1st single-cell #SpatialTranscriptomics map of human coronary #Atherosclerosis published in peer-reviewed format🤠

CosMx 1k + GeoMx @brukerspatial

Immune cell-focused analysis

Use CosMx data to deconvolve GeoMx cell composition...😆

#EmboMolMed 2025
www.embopress.org/doi/full/10....

Metabolic signatures for gastric cancer diagnosis and mechanistic insights: a multicenter study | EMBO Molecular Medicine imageimageA six-metabolite plasma panel was developed and validated for gastric cancer (GC) diagnosis using UPLC-MS and machine learning, revealing diagnostic potential and a mechanistic role for isov...

Metabolic signatures for gastric cancer diagnosis and mechanistic insights: a multicenter study #EMBOMolMed #MassSpec www.embopress.org/doi/full/10....

High-throughput microfluidic 3D Microvessel On A Chip models #CerebralMalaria
φ100 μm
Collagen hydrogel
👤🧠Endothelial Cell+Pericyte

P. falciparum-infected RBC egress product▶️
⏬Pericyte processes
⏫Permeability
Rescued by Angpt1 or AKB-9778 (Tie2.a)

#EmboMolMed 2025
www.embopress.org/doi/full/10....

Versican, but not Aggrecan, ➡️⏫AKT-iNOS➡️⏫🐭Fbn1C1041G/+ #MarfanSyndrome

Vcan, but not Acan, hetero KO ⏬#AorticAneurysm of Marfan🐭

Lentiviral shVcan start⏬ascending & abdominal aortic diameters in 3 days!!🥸

#AortaEd
#EmboMolMed 2024
www.embopress.org/doi/full/10....

MicroRNA-33 inhibition ameliorates muscular dystrophy by enhancing skeletal muscle regeneration | EMBO Molecular Medicine imageimageIn this study miR-33a/b were identified as negative regulators of skeletal muscle regeneration by targeting Cdk6, Fst, and Abca1. Inhibition of miR-33a/b can be a promising strategy for the ...

New #EmboMolMed paper with our accompanying news and views on: MicroRNA-33 inhibition ameliorates muscular dystrophy by enhancing skeletal muscle regeneration. #Myoblue tinyurl.com/43cyhfz2

Ontology-guided clustering enables proteomic analysis of rare pediatric disorders | EMBO Molecular Medicine imageimageThis discovery-driven proteomics study of a pediatric population - including rare diseases - introduces a SNOMED CT-guided clustering framework that enables analysis across underpowered cond...

Ontology-guided clustering enables proteomic analysis of rare pediatric disorders #EMBOMolMed #MassSpec www.embopress.org/doi/full/10....

FOXK2 in skeletal muscle development: a new pathogenic gene for congenital myopathy with ptosis | EMBO Molecular Medicine imageimageFOXK2 was identified as a novel pathogenic gene for congenital myopathy associated with ptosis and was shown to play a previously unreported, significant role in skeletal muscle development....

New #EmboMolMed paper: FOXK2 in skeletal muscle development: a new pathogenic gene for congenital myopathy with ptosis. #Myoblue tinyurl.com/w85ahfzv

X-linked myopathy with excessive autophagy: characterization and therapy testing in a zebrafish model | EMBO Molecular Medicine imageimageX-linked myopathy with excessive autophagy (XMEA) is a rare disease for which pre-clinical models lack, challenging the ability to understand mechanisms and therapies. The use of the zebrafi...

Excited to share this new collaborative #EmboMolMed work from my lab #ChildrensAL & Jim Dowling labs. Work highlights efforts to generate a new animal model for X-linked myopathy with excessive autophagy (XMEA) and perform corrective drug screening. 1/n tinyurl.com/ym7svnwm