#SpatialTranscriptomics #CellSegmentation

FastReseg
github.com/Nanostring-B...

Using transcript scoring +"spatial doublet" test to rectify segmentation errors🥸

vs transcript-dominant approaches: Baysor Proseg

#SciReports 2025
www.nature.com/articles/s41...

https://www.nature.com/articles/s41598-026-40047-y

New #SciReports paper: MyoFuse is a fully AI-based workflow for automated quantification of skeletal muscle cell fusion in vitro. #Myoblue tinyurl.com/4tjbcnvd

Partial aortic endothelial detachment from disorganized internal elastic lamina, + #EndothelialCell α5⏫ β1⏬ integrin, in a🐭#MarfanSyndrome model mgΔlpn/+ 6-mo♂️ (Already #AorticAneurysm...)

#AortaEd
#SciReports 2025
www.nature.com/articles/s41...

📣 Happy to share the latest article from our lab in #SciReports:
“A multiparametric perspective on C6 and F98 cell lines in orthotopic rat models for glioblastoma research” 🧠 🧲
🔗 rdcu.be/eunTJ
Choosing the appropriate experimental model is crucial! #GBM #MRI #MRS #IIBM #CSIC

Oopsies.

Courtesy of journal #SciReports and researchers from China plus one "internationally known researcher" from University of Texas Southwestern Medical Center.

pubpeer.com/publications...

⭐️New #CETIPaper out in #SciReports! CETI scientists developed the first automatic sperm whale coda detector and annotator.

Read the paper here: bit.ly/42SwWAb and find the publicly available code on our #Github: ​​https://github.com/Project-CETI/Coda-detector !
📸: Amanda Cotton

Creation of knockin mice for the fluorescence protein based in vivo identification of skeletal myofiber types - Scientific Reports Scientific Reports - Creation of knockin mice for the fluorescence protein based in vivo identification of skeletal myofiber types

Interesting new #SciReports paper: Creation of knockin mice for the fluorescence protein based in vivo identification of skeletal myofiber types. #Myoblue tinyurl.com/mznpypy7

#Brain volume loss may help identifying #LVAD-supported #heart patients at risk for postoperative #delirium. Read the new paper by @docnandan.bsky.social #ivanmurrietaa #DrKenLiao #DrTRosengart et al in #SciReports @bcmhouston.bsky.social #BCM_Surgery www.nature.com/articles/s41...

Young men with late puberty have healthier fat-to-muscle ratios Later puberty in young men is linked to lower bone volume and lean mass, but a healthier body composition. Earlier puberty leads to higher bone density and slightly higher BMI and fat mass.

Young men with late puberty have healthier fat-to-muscle ratios 🧬🦴📊 www.news-medical.net/news/2025032... #Puberty #BoneHealth #BodyComposition #DXAStudy #MensHealth #YouthDevelopment #Osteoporosis #MuscleMass #SciReports

Label-free proteomic analysis of Duchenne and Becker muscular dystrophy showed decreased sarcomere proteins and increased ubiquitination-related proteins - Scientific Reports Scientific Reports - Label-free proteomic analysis of Duchenne and Becker muscular dystrophy showed decreased sarcomere proteins and increased ubiquitination-related proteins

New #SciReports paper: Label-free proteomic analysis of Duchenne and Becker muscular dystrophy showed decreased sarcomere proteins and increased ubiquitination-related proteins. #MyoBlue tinyurl.com/y8xvn9w6

Indirect evidence of an early mating advantage in wild cooperatively breeding male banded mongooses Scientific Reports - Indirect evidence of an early mating advantage in wild cooperatively breeding male banded mongooses

#Reproductive #ecology paper out in #SciReports!
rdcu.be/d5IEk

Early mating advantage in male banded #mongooses linked to some novel glue-like properties in their ejaculates.

Thanks Michael Cant, Jon Blount, Magali Meniri, and Hazel Nichols. Francis Mwanguhya and Robert Businge led all fieldwork.

Mirror-invariance is not exclusively visual but extends to touch - Scientific Reports Scientific Reports - Mirror-invariance is not exclusively visual but extends to touch

Mirror-invariant object recognition is not exclusively visual: check out our new study in blind and blindfolded sighted individuals just published in #SciReports with Maks Korczyk and Marcin Szwed! 🥳 ⬇️⬇️⬇️
nature.com/articles/s41...
A 🧵below ⬇️

Immunologic investigations into transgene directed immune-mediated myositis following delandistrogene moxeparvovec gene therapy - Scientific Reports Scientific Reports - Immunologic investigations into transgene directed immune-mediated myositis following delandistrogene moxeparvovec gene therapy

New #SciReports paper: Immunologic investigations into transgene directed immune-mediated myositis following delandistrogene moxeparvovec gene therapy. #MyoBlue tinyurl.com/23nhsvsc

#Valvulogenesis #Elastogenesis #Pigmentation

Melanocyte-like (Acta2+Tyr+) #ValvularInterstitialCell is the major depositor of Elastic Fiber in🐭developing aortic valve

Valvular elastin fiber
⏫in hyperpigmented K5-Endothelin 3🐭
⏬in Albino Tyr mutant 🐭

#SciReports 2024
www.nature.com/articles/s41...

Age (3/6/12/24 mo) & Sex (♀️♂️) on Mouse (C57BL/6NRj) Organ (Brain/Heart/Liver/Lung/Skeletal Muscle) Metabolomics
]
A biphasic pattern of #MetabolicAging
Some metabolites eg. branched-chain amino acids, peak at 6 mo then return to baseline by 12~24 mo

#SciReports 2022
www.nature.com/articles/s41...

PD-L1 #Atherosclerosis

"Patients with MACEs had a higher number of MPO-stained cells (p=0.044) & lower PD-L1 staining intensity (p=0.021) in atheromatous plaques compared with those of patients with a stable prognosis"

Which cell types are PD-L1+?

#SciReports 2024
www.nature.com/articles/s41...

#LongNonCodingRNA #LncRNA transcriptomics Lower-extremity #PeripheralArteryDisease -/+ T2D #Diabetes

Iliac artery n=79
T2D->⏬ACTA2-AS1

#SmoothMuscleCell microdissected from FFPE section
T2D->⏫LINC00910/RUFY1-AS1 ⏬HIF1A-AS3/XIST!/NEAT1/MIR222HG

#SciReports 2024
www.nature.com/articles/s41...

Modeling #SARSCOV2 inflammatory responses (interferon, CCL, IL6) #CytokineStorm with hPSC-derived #VascularImmuneOrganoid

@riosugimura.bsky.social #SciReports 2024
link.springer.com/article/10.1...

Myocardin family⏬cGAS-STING-inflammation in arterial & airway #SmoothMuscleCell

MYOCD/MRTFA/MRTFB overexpression⏬p-TBK1 (MRTFA binds to TBK1)
STING minimally phosphorylated at Ser366

GTEx: ➖corr MYOCD/MRTFA/SRF vs cGAS-STING genes in aorta/arteries

#SciReports 2024
www.nature.com/articles/s41...

Community dynamics and metagenomic analyses reveal Bacteroidota's role in widespread enzymatic Fucus vesiculosus cell wall degradation

#SciReports from Ines Krohn and Wolfgang Streit

www.nature.com/articles/s41...

Human placental #Pericyte co-culture protects microvascular network (HUVECs #Microfluidics) from nutrient deprivation [Network integrity] or cationic silica nanoparticle [Vessel size, Cell viability, Fibronectin deposit]

#VascularPermeability?

#SciReports 2023
www.nature.com/articles/s41...

Oxygen-dependent biofilm dynamics in leaf decay: an in vitro analysis

#SciReports by Sabina Karačić et al

www.nature.com/articles/s41...

#Sirt6⏫Lung #Metastasis of HER2+ #BreastCancer

IL12A & TBX3⏬by SIRT6-H3K8Ac axis

"In the context of HER2-amplified breast cancer, either TBX3 loss-of-function or SIRT6 amplification predicts a worse survival"

#SciReports 2023
www.nature.com/articles/s41...