Microvascular morpho-dynamics #Angiogenesis in🐭 #AcutePancreatitis cerulein
⏬Microvascular ramification
⏫Luminal dilation
⏫ #VascularPermeability ⏬VE-cad

Acinar VEGFA KO ⏬microvascular remodeling
↔️Acinar-to-ductal metaplasia, Mφ infiltr, islet mass

bioRxiv 2025
www.biorxiv.org/content/10.1...

#EndothelialCell Neuropilin-1/NRP1 controls VEGFA-mediated #VascularPermeability in tissue-specific manner

🐭Ear Skin⏬
Back skin & Trachea⏫

A potential role of peri-endothelial NRP1 modifies VEGFA-VEGFR2-VE-Cadherin cascade🤓

Fig 2E/F?😳

#Angiogenesis 2024
link.springer.com/article/10.1...

#EndothelialCell #Senescence #DiabeticRetinopathy

STING KO🐭or STING Golden Ticket🐭are resistant to STZ diabetic retinal capillary regression, pericyte loss, #VascularPermeability (BSA), leukostasis (intravascular bound leukocyte)

#JCI_insight 2023
insight.jci.org/articles/vie...

Human placental #Pericyte co-culture protects microvascular network (HUVECs #Microfluidics) from nutrient deprivation [Network integrity] or cationic silica nanoparticle [Vessel size, Cell viability, Fibronectin deposit]

#VascularPermeability?

#SciReports 2023
www.nature.com/articles/s41...

Hierarchical microvasculature on a chip

Arteriole (φ400 μm #ViscousFingerPattening Collagen) -Capillary (self-assembly) -Venule

Arteriole can contract by ~2%φ

#VascularPermeability

Circulating tumor cell/T cell extravasation

Roger Kamm lab, Lab on a Chip 2023
pubs.rsc.org/en/content/a...