Function 🔙 #ThrowBackThursday: Lewis et al. investigated a new approach for treating #AcutePancreatitis! Their data show that a combo of #CM4620 and #galactose synergistically targets pathological mechanisms of AP. Read more: 10.1093/function/zqae017

Acute pancreatitis is driven by complex inflammatory and immune mechanisms, with emerging therapeutic approaches targeting disease initiation and progression.
doi.org/10.1038/s413...
#AcutePancreatitis #Inflammation #InnateImmunity #TherapeuticTargets

This review highlights #AcutePancreatitis as a global health burden, summarizing causes, classification, and advances in #AI-based risk tools, #biomarkers, and therapies, while exploring mechanisms, adjunctive treatments, and emerging strategies.

#STTT: doi.org/10.1038/s413...

An overview of the epidemiology, etiology and classification of #AcutePancreatitis, outlining the multi-level pathological mechanisms, with insights into #TraditionalChineseMedicine and emerging therapeutic strategies.

#STTT #OpenAccess: doi.org/10.1038/s413...

"New at JCAT-radiology
'Quantitative Evaluation of Acute Pancreatitis Based on Dual-Energy Computed Tomography'
Nov/Dec 25 tinyurl.com/3rs9e94d Au: Yuting Lu et al.
#AcutePancreatitis #dualEnergyCt"

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#Pancreatitis #AcutePancreatitis #ChronicPancreatitis #Pancreas (🧵6/6)

#Pancreatitis #AcutePancreatitis #ChronicPancreatitis #PEI #PERT

[VD: Chloé, wearing a Guts UK t-shirt and sits indoors in front of a teal wall. She speaks directly to the camera, busting common myths about pancreatitis.] (🧵3/3)

Let’s get to grips with pancreatitis by learning the differences and how these conditions affect people, by watching our video. 💚

#Pancreatits #AcutePancreatitis #ChronicPancreatitis #ChronicIllness #InvisibleIllness (🧵4/4)

#Pancreatitis #Awareness #Pancreas #GutHealth #ChronicIllness #AcutePancreatitis #ChronicPancreatitis

Acute Pancreatitis | Definition, Causes, Symptoms, Diagnosis & Treatment 🩺
Read full blog 👉 chk.me/micRW6P #AcutePancreatitis #PancreasHealth #MedicalAwareness #StayHealthy #VikaasShandily

Early endoscopic drainage of WON in #acutepancreatitis is better than late and avoid #PPI with cyst:WON drainage to prevent occlusion.

Plasmapheresis for Hypertriglyceridemia-induced Acute Pancreatitis: A Systematic Review and Meta-summary of Case Reports Hypertriglyceridemia is the third most common cause of acute pancreatitis (AP). However, the evidence on the management of hypertriglyceridemia-induced AP is lacking.

'Plasmapheresis for Hypertriglyceridemia-induced Acute Pancreatitis: A Systematic Review and Meta-summary of Case Reports' - a #JaypeeJournals 'Preventive and Emergency Medicine Insights' publication on #ScienceOpen:

🖇️ #Hypertriglyceridemia #AcutePancreatitis #Plasmapheresis #CriticalCare

💥 New Review examines #AcutePancreatitis in children and its unique challenges, which are distinct from adult manifestations. Click the link to learn more: www.gastrojournal.org/article/S0016-5085(25)00633-X/fulltext
#PediatricPancreatitis #PancreatitisAwareness

Microvascular morpho-dynamics #Angiogenesis in🐭 #AcutePancreatitis cerulein
⏬Microvascular ramification
⏫Luminal dilation
⏫ #VascularPermeability ⏬VE-cad

Acinar VEGFA KO ⏬microvascular remodeling
↔️Acinar-to-ductal metaplasia, Mφ infiltr, islet mass

bioRxiv 2025
www.biorxiv.org/content/10.1...

#SpatialTranscriptomics #Aging #AcutePancreatitis

18- vs 3-mo ♂️🐭+caerulein
#Visium

⏫Inflammation in both Acinar & Stromal cells (even DEGs are similar b/w there 2 compartments)
↔️Major cellular pancreatic fractions

Aging traits of inflamed islets?

#JMolMed 2024
link.springer.com/article/10.1...

Septic shock caused by postpartum acute pancreatitis, a case report and literature review - International Journal of Emergency Medicine Introduction Postpartum acute pancreatitis (PAP) is a rare but potentially life-threatening condition that can occur following childbirth. The incidence of PAP is estimated to be between 1 in 1,000 an...

Rare but life-threatening postpartum #AcutePancreatitis can lead to #SepticShock. Prompt diagnosis and urgent endoscopic retrograde cholangiopancreatography plus surgery are vital. Awareness saves lives. #Gallstones #Sepsis intjem.biomedcentral.com/articles/10....

🔹 Welcome to #TrigTriviaTuesday - where we help boost your #TrigIQ.

Did you know high triglycerides can trigger #AcutePancreatitis— and it’s often more severe and deadly than other causes?

Even one episode increases future risk. Repeated flares? They can lead to #chronicpancreatitis or worse.

Today I had the honor to present some of the statements of the upcoming UEG-EPC-supported european consensus guideline on pain management in #acutepancreatitis at the #EPC2025

Clinical Significance of Serum CTRP3 Level in the Prediction of Cardiac and Intestinal Mucosal Barrier Dysfunction in Patients with Severe Acute Pancreatitis

www.dl.begellhouse.com/journals/2ff...

#CardiacResearch #Biomarkers #AcutePancreatitis #GutBarrierFunction

Gaps and uncertainties in the management of acute pancreatitis: a scoping review and quality assessment of clinical practice guidelines

Demonstrates the pressing need for greater standardisation and harmonisation of #acutepancreatitis guidelines

www.thelancet.com/journals/ecl...
#MedSky

… and so the story continues @demadaria.bsky.social presenting the #Waterfinder study in #acutepancreatitis as a follow-up to the #Waterfall trial to find the optimal fluid resuscitation

@demadaria.bsky.social presenting 🧑‍🏫 #PROM for #acutepancreatitis ie the PAN-PROMISE symptom Score during the #IPBM2025 🇰🇷 as used for the #Waterfall study 📚 . Appears to be very useful! 📉

Biochemical analyses of cystatin-C dimers and cathepsin-B reveals a trypsin-driven feedback mechanism in acute pancreatitis | Nature Communications Acute pancreatitis (AP) is characterised by self-digestion of the pancreas by its own proteases. This pathophysiological initiating event in AP occurs inside pancreatic acinar cells where intrapancreatic trypsinogen becomes prematurely activated by cathepsin B (CTSB), and induces the digestive protease cascade, while cathepsin L (CTSL) degrades trypsin and trypsinogen and therefore prevents the development of AP. These proteases are located in the secretory compartment of acinar cells together with cystatin C (CST3), an endogenous inhibitor of CTSB and CTSL. The results are based on detailed biochemical analysis, site-directed mutagenesis and molecular dynamics simulations in combination with an experimental disease model of AP using CST3 deficient mice. This identifies that CST3 is a critical regulator of CTSB and CTSL activity during AP. CST3 deficient mice show a higher intracellular CTSB activity resulting in elevated trypsinogen activation accompanied by an increased disease sever

Biochemical analysis reveals trypsin-driven feedback in acute pancreatitis: Cystatin-C dimers, cathepsin B & trypsinogen are key players. #AcutePancreatitis PMID:39962054, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56875-x #Medsky #Pharmsky #RNA 🧪

a medical information about a patient

#AcutePancreatitis is the most frequent pancreatic disease
📌 26–43 cases per 100,000 people per year
📌 10–15% of cases are severe
📌 24.1% of all patients will progress to chronic pancreatitis.
🔗 Access this and other online courses on Gutflix: https://bit.ly/424DRaj

#myUEGcommunity

<em>Journal of Internal Medicine</em> | Wiley Online Library Background and Aims Patients with alcohol-related liver disease (ALD) might be at increased risk of acute pancreatitis (AP), but large-scale data are lacking. Methods Population-based cohort study...

Fresh from the press: 6️⃣x 📈 of #acutepancreatitis in 🍷 liver disease
@anadugic @hanneshagstrom

doi.org/10.1111/joim...

Olezarsen, Acute Pancreatitis, and Familial Chylomicronemia Syndrome | NEJM Familial chylomicronemia syndrome is a genetic disorder associated with severe hypertriglyceridemia and severe acute pancreatitis. Olezarsen reduces the plasma triglyceride level by reducing hepati...

MedSky🧪 #Cardiosky🫀 Olezarsen, #AcutePancreatitis & Familial Chylomicronemia Syndrome In patients with #familialchylomicronemiasyndrome, #olezarsen may represent a new therapy to reduce plasma triglyceride levels.

www.nejm.org/doi/pdf/10.1...