Now accepting applications 🚨

The Ionis Cardiometabolic Young Investigator Grant supports early-career researchers advancing severe #hypertriglyceridemia.

📩 Learn more: https://ionis.com/about-us/grants-and-sponsorships

#Cardiology #Research #EarlyCareer #Hypertriglyceridemia #CardioSky #MedSky

Now accepting applications 🚨 The Ionis Cardiometabolic Young Investigator Grant supports early-career researchers advancing severe #hypertriglyceridemia.
📩 Learn more: https://ionis.com/about-us/grants-and-sponsorships
#Cardiology #Research #EarlyCareer #Hypertriglyceridemia #CardioSky #MedSky

| Efficacy and safety of #antisenseoligonucleotide therapies targeting APoC-III in patients with severe #hypertriglyceridemia: a meta-analysis of randomized controlled trials | doi.org/10.4081/mona... | #openaccess #academicsky #medsky |

First-in-human drug trial lowers high blood triglycerides – BioNews Central An oral compound was developed to lower triglycerides by selectively inhibiting Liver X Receptor in the liver and gut, offering a potential treatment for high triglyceride-related diseases. ...

An oral #compound was developed to lower #BloodTriglycerides by selectively inhibiting #LiverXReceptor in the #liver and #gut, offering a potential treatment for high triglyceride-related diseases.
#Triglycerides #Hypertriglyceridemia #Dyslipidemia

TLR7 F507S gain-of-function mutation presenting with early-onset #SLE and #hypertriglyceridemia: Response to JAK inhibition. New report from Nima Parvaneh, Vahid Ziaee and colleagues (Tehran University of Medical Sciences): rupress.org/jhi/article/...

#Autoinflammation #InbornErrorsOfImmunity

Parvaneh, Ziaee et al. present a patient harboring the TLR7 F507S mutation who initially presented with refractory #thrombocytopenia that evolved into #SLE with subtle neurologic features, accompanied by #hypertriglyceridemia. rupress.org/jhi/article/...

#Autoimmunity #InbornErrorsOfImmunity

In @jhumimmunity.org, Parvaneh, Ziaee et al. present a patient harboring the TLR7 F507S mutation who initially presented with refractory #thrombocytopenia that evolved into #SLE with subtle neurologic features, accompanied by #hypertriglyceridemia. rupress.org/jhi/article/...

#Autoimmunity

Olezarsen lowers triglycerides and pancreatitis risk in severe hypertriglyceridemia Treatment with olezarsen may significantly reduce triglyceride levels and result in fewer acute pancreatitis events among adults with severe hypertriglyceridemia.

#MedNews - Treatment with #olezarsen may significantly reduce triglyceride levels and result in fewer acute #pancreatitis events among adults with severe #hypertriglyceridemia.

👉 buff.ly/UGgiUQY

#CardioSky

From #ESCCongress 2025 - Dr. Brian Bergmark outlines the ESSENCE-TIMI 73b trial investigating #olezarsen in patients with moderate #hypertriglyceridemia and high cardiovascular risk.

Watch the full interview here 👉 buff.ly/cm1SuCn

#CardioSky #CVD

Plasmapheresis for Hypertriglyceridemia-induced Acute Pancreatitis: A Systematic Review and Meta-summary of Case Reports Hypertriglyceridemia is the third most common cause of acute pancreatitis (AP). However, the evidence on the management of hypertriglyceridemia-induced AP is lacking.

'Plasmapheresis for Hypertriglyceridemia-induced Acute Pancreatitis: A Systematic Review and Meta-summary of Case Reports' - a #JaypeeJournals 'Preventive and Emergency Medicine Insights' publication on #ScienceOpen:

🖇️ #Hypertriglyceridemia #AcutePancreatitis #Plasmapheresis #CriticalCare

It’s #TrigTriviaTuesday! 💥

Pancreatitis risk doesn’t wait—so here’s your quick quiz:

At what TG level does risk really spike?

A) >250 mg/dL
B) >500 mg/dL
C) >1,000 mg/dL
D) >2,000 mg/dL

Drop your guess & let’s talk TGs + pancreatitis ⬇️
#TrigTriviaTuesday #Hypertriglyceridemia #MedEd

Free Webinar – July 1 at 12PM ET
Join Dr. Seth J. Baum + Dr. James A. Underberg to gain insights into diagnosing + managing Severe Hypertriglyceridemia
🧠 Insightful. 🔍 Practical. 💬 Live Q&A.
📍 Register: nta.ampstream.io/nta1
@nattgalliance.bsky.social
#SevereHTG #Hypertriglyceridemia #CardioSky

us02web.zoom.us/webinar/regi...

#Lipids #Hypertriglyceridemia #triglycerides #CVD #cardiovasculardisease

Screenshot of Table 1: ACMG/AMP-based criteria considered for variant pathogenicity assessment

Implementing the #ACMG/AMP guidelines is no simple task. Study offers a #pathogenicity assessment of genetic #variants found in patients with severe #hypertriglyceridemia, shedding light on the diagnosis of #familialchylomicronemiasyndrome bit.ly/3DKXbjk

Effects of Hypertriglyceridemia With or Without NEFA Elevation on β-cell Function and Insulin Clearance and Sensitivity AbstractContext. Hypertriglyceridemia is a risk factor for developing type 2 diabetes (T2D) and might contribute to its pathogenesis either directly or thr

Effects of #hypertriglyceridemia with or without NEFA elevation on β-cell function and #insulin clearance and sensitivity: new Featured study in #JCEM. #FreeToView
#T2D #FattyAcids #lipids #BetaCell #diabetes
@endocrinesociety.bsky.social
doi.org/10.1210/clin...

Hemophagocytic Lymphohistiocytosis | NEJM HLH, a cytokine-mediated hyperinflammation syndrome, causes fever, pancytopenia, and hemophagocytosis and is often fatal. Antiinflammatory agents, etoposide, and interferon-γ antibody are the main ...

Hemophagocytic Lymphohistiocytosis
🔹Life-threatening syndrome of overwhelming inflammation
🔹Is crucial to search and treat the underlying trigger
🚩Fever, #Splenomegaly, #Cytopenia, #hyperferritinemia, #hypertriglyceridemia, bone marrow #hemophagocytosis

#HLH
@nejm.org

www.nejm.org/doi/pdf/10.1...

In a Phase 2b trial, Olezarsen, targeting APOC3, significantly reduced triglycerides in patients (levels 150-499 mg/dL) at high cardiovascular risk. Exciting results for #hypertriglyceridemia! #cardiovascularhealth PMID:38587249, N Engl J Med 2024