JCI Insight - Spatial-proteomics reveals recombinant human laminin-111 restores adhesion-signaling to laminin-α2 deficient muscle

Congrats to Dean Burkin & colleagues for their new #JCI_insight paper: Spatial-proteomics reveals recombinant human laminin-111 restores adhesion-signaling to laminin-α2 deficient muscle. #Myoblue tinyurl.com/my6ebn3z

JCI Insight - Matrix metalloproteinases are hallmark early biomarkers and therapeutic targets in FSHD

New #JCI_insight paper: Matrix metalloproteinases are hallmark early biomarkers and therapeutic targets in FSHD. #Myoblue tinyurl.com/3w9khp4n

JCI Insight - Differential pathology and susceptibility to MBNL loss across muscles in myotonic dystrophy mouse models

Congrats to #MDavenport93 Maury Swanson and colleagues for their new #JCI_insight paper: Differential pathology and susceptibility to MBNL loss across muscles in myotonic dystrophy mouse models. #Myoblue tinyurl.com/r742p763

JCI Insight - Macrophage-derived Spp1 promotes intramuscular fat in dystrophic muscle

New #JCI_insight paper from Villalta and Spencer labs: Macrophage-derived Spp1 promotes intramuscular fat in dystrophic muscle. #Myoblue tinyurl.com/hrwfrkus

JCI Insight - Vitamin A-Retinoic Acid Contributes to Muscle Stem Cell and Mitochondrial Function Loss in Old Age

Congrats to #aguilarlab_UM and colleagues for their new #JCI_insight paper: Vitamin A-Retinoic Acid Contributes to Muscle Stem Cell and Mitochondrial Function Loss in Old Age. #Myoblue tinyurl.com/bddhtnht

JCI Insight - Fibroblast growth factor-inducible 14 regulates satellite cell self-renewal and expansion during skeletal muscle repair

New #JCI_insight paper: Fibroblast growth factor-inducible 14 regulates satellite cell self-renewal and expansion during skeletal muscle repair. #MyoBlue tinyurl.com/52xznpcx

Perturbed Hyaluronan Metabolism by Trophoblast overexpressing HYAL2 or HAS2 Disrupts Maternal-Embryo barrier
⏫Decidual Angiogenesis
⏬VEGFR3+ vascular sinuous folds
⏫MAC2+ Macrophage/Dendritic Cell
⏬DBA+ uterine NK cells

#SciArt
#JCI_insight 2020
insight.jci.org/articles/vie...

and I would expect editors at #JCI_Insight to know/enforce English grammar

JCI Insight - Rapamycin improves satellite cells autophagy and muscle regeneration during hypercapnia

New #JCI_Insight paper: Rapamycin improves satellite cells autophagy and muscle regeneration during hypercapnia. tinyurl.com/3ntzta65

#EndothelialCell #Senescence #DiabeticRetinopathy

STING KO🐭or STING Golden Ticket🐭are resistant to STZ diabetic retinal capillary regression, pericyte loss, #VascularPermeability (BSA), leukostasis (intravascular bound leukocyte)

#JCI_insight 2023
insight.jci.org/articles/vie...

#BoneFracture #Neurofibromatosis 1
#SpatialTranscriptomics

Postn-Cre::Nf1 f/f🐭
#Psaudarthrosis 10 y/o👤

SpatialTime analysis➡️
1⃣TGFβ signaling persists lining fracture plane
2⃣Wnt, BMP sig diminished at the periosteum & along the bony ends
3⃣⏫MAPK sig

#JCI_insight 2024
insight.jci.org/articles/vie...

Placental mTOR for🐭offspring metabolic health
#FetalGrowthRestriction #LowBirthWeight

Placental (CYP19-Cre) mTOR KO+HFD
⏫weight gain
⏬food intake
⏫Hyperglycemia, Glucose intolerance, Insulin resistance
⏬energy expenditure
More severe in ♀️offspring

#JCI_insight 2021
insight.jci.org/articles/vie...