#BoneFracture #Neurofibromatosis 1
#SpatialTranscriptomics

Postn-Cre::Nf1 f/f🐭
#Psaudarthrosis 10 y/o👤

SpatialTime analysis➡️
1⃣TGFβ signaling persists lining fracture plane
2⃣Wnt, BMP sig diminished at the periosteum & along the bony ends
3⃣⏫MAPK sig

#JCI_insight 2024
insight.jci.org/articles/vie...