Cellular #Senescence & Compromised #TightJunction in #SubmandibularGland in🐭Natural #Aging (18-mo) or D-galactose (for 8 wk)

Interestingly, SA β-Gal activity was only evident in aged SMG, not parotid or sublingual glands.

#AgingCell 2025
onlinelibrary.wiley.com/doi/full/10....

NK cells restrain cytotoxic CD8+ T cells in the submandibular gland via PD-1–PD-L1 PD-L1–expressing NK cells restrain cytotoxic CD8+ T cells in the SMG, providing insights into disrupted immunoregulation contributing to irAEs.

Now in #Science #Immunology: Borys, Brossay, &al describe how #PD1 deficiency or tx w/ anti- #PDL1 Ab → expansion of pathogenic GzmK+ #CD8 #TCells in #SubmandibularGland normally controlled by PD-L1+ #NKCells. This may explain a common immune-related adverse event ( #irAE ) associated with #ICB!