Frontiers | Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome IntroductionMyalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic disease hallmarked by multiple systemic symptoms, such as neurocognitive...

Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Sonya Marshall-Gradisnik et al. 🇦🇺

#ME/CFS #TRPM3 #IonChannel #NKcells

🩸🔍Today’s question!

Swipe to see the answer and its explanation!

#Hematology #Myelofibrosis #MPN #MyeloproliferativeNeoplasms #Ruxolitinib #Immunotherapy #NKCells #CellTherapy #HemOnc #Oncology #BloodDisorders #MedEd #MedicalEducation #HEMEHUB

📣 #EFIS Education Task Force invites you to another webinar in the "Landmark Discoveries in Immunology" series!

💥 Registration is free 👇
🔗 www.efisedu.de/webinar
🗓️ March 5 at 17:00 CET

✨ Share and invite your colleagues!
#immunology #NKCells #ImmunologyEducation

@yefis-immunology.bsky.social

The Leonardo Apheresis Platform from an Oncology Platform to an Immune Restoration Platform

A closer look at ImmunityBio’s Leonardo platform: CD3/CD14-depleted, IL-12/15/18-primed m-ceNK monotherapy followed by biomarker-guided IL-15 support — and the expansion into iNKT for lymphopenic sepsis.
#CellTherapy #Immunotherapy #NKcells

huggenberg.substack.com/p/the-leonar...

Disarming the Natural Killers: Mechanisms of NK Cell Dysfunction in Hematological Malignancies Natural Killer (NK) cells are innate lymphocytes that provide rapid first-line defense against infected and transformed cells through receptor-mediate…

🔗 The full article is available at the following link: sciencedirect.com/science/arti...

#NKcells #Immunology #CancerResearch #CollaborativeResearch

🩸Facts about Multiple Myeloma:

Myeloma Biology and Microenvironment

#MultipleMyeloma #Hematology #NKcells #Cytogenetics #HEMEHUB #TP53 #NFkB #Hyperdiploidy #t1114 #del17p #HemOnc #MedEd

The maturation process of lymphocytes and how Anktiva, an IL-15 superagonist, enhances these processes A comprehensive, step-by-step summary of the key processes in Immunology 2.0 and their potential to transform standard cancer care.

Why are lymphocytes often neglected in cancer treatment, and what changes are necessary?
huggenberg.substack.com/p/fundamenta...
#Immunotherapy #PrecisionMedicine #CancerResearch #NKcells #Lymphopenia #CARNK #immunosky

Excess Cdc42 activity weakens NK cell clearance of senescent cells in aging

Third round of abstracts is now OPEN!

Submit your abstract and share your research with the global aging science community.

agingcongress.com/edition2//ab...

#Aging #Immunosenescence #NKCells #AgingResearch

This #WorldCancerDay, explore how boosting natural killer (NK) cell activity, from CAR‑NK therapies to NK‑cell engagers and checkpoint strategies, could strengthen our fight against cancer.

Read the open access review: https://bit.ly/4j8dKEW

#Immunotherapy #NKcells

VCU researchers win $1.8 million US DoD grant for cancer therapy The US Department of Defense (DoD) grant funds engineered NK cell therapy for resistant prostate cancer.

VCU researchers awarded $1.8M DoD grant to develop a novel engineered NK cell therapy targeting incurable, advanced prostate cancer (CRPC).
#News #ProstateCancer #Immunotherapy #CRPC #CellTherapy #NKcells #IL24 #DoDgrant

VCU researchers win $1.8 million US DoD grant for cancer therapy The US Department of Defense (DoD) grant funds engineered NK cell therapy for resistant prostate cancer.

VCU researchers awarded $1.8M DoD grant to develop a novel engineered NK cell therapy targeting incurable, advanced prostate cancer (CRPC).
#News #ProstateCancer #Immunotherapy #CRPC #CellTherapy #NKcells #IL24 #DoDgrant

Continuing our tribute to Dr. Anahid Jewett's immunology work: Dr. Jewett and colleagues examine how NK and CD8+ T cells contribute to ALS pathogenesis, discussing targeted therapies including supercharged NK cells.

Free until Feb 15: www.dl.begellhouse.com/references/2...

#ALS #NKCells

In honor of Dr. Anahid Jewett's legacy, we're highlighting her contributions to immunology. This review explores how probiotics activate NK cells, enhance cancer therapeutics, and reverse functional impairment.

Read free until Feb 15: www.dl.begellhouse.com/journals/2ff...

#Probiotics #NKCells

This comprehensive review by Dr. Anahid Jewett and UCLA researchers demonstrates how NK cells select and differentiate cancer stem cells, leading to growth inhibition and reduced metastasis.

Free to read until Feb 15th:
dl.begellhouse.com/journals/2ff...

#NKCells #CancerImmunotherapy

Scientists Unveil Breakthrough Method to Mass-Produce Cancer-Fighting Natural Killer Cells A new method for engineering natural killer cells could make cancer immunotherapy more efficient, scalable, and affordable, potentially reshaping how these treatments are produced.

Scientists unveil breakthrough method to mass-produce cancer-fighting NK cells.
Scaling CAR-NK therapy could bring powerful immune treatments to far more patients. Big science, real hope.
scitechdaily.com/scientists-u...
#CancerResearch #Immunotherapy #NKCells #CAR #TCSC

Bringing Natural killer cells to the clinic: opportunities beyond #cancer. New review from Marjorie Cayatte, Valentin Picant, Marie Vétizou, and Eric Vivier @ciml.bsky.social: rupress.org/jem/article/...

#Autoimmunity #NKCells #Neurodegeneration

New review in @jem.org by Cayatte, Picant, Vétizou, & @ericvivier.bsky.social explores the expanding roles of #NKcells beyond #cancer, highlighting their pivotal functions in viral #infections, #neurodegeneration, #autoimmune diseases, and #transplantation medicine rupress.org/jem/article/...

New review by Cayatte, Picant, Vétizou, & @ericvivier.bsky.social @ciml.bsky.social explores the expanding roles of #NKcells beyond #cancer, highlighting their pivotal functions in viral #infections, #neurodegeneration, #autoimmune diseases, and #transplantation medicine rupress.org/jem/article/...

Frontiers | Engineering with care: safety assessment platforms for CRISPR-modified natural killer cells CRISPR-based gene editing has become a transformative tool to enhance immune cell therapies. In particular, engineering natural killer (NK) cells with CRISPR...

🚨Paper alert! Happy to share our review on safety assessments for gene-edited #NKcells. A highly timely topic for future multiplex-edited NK cells!
Proud of my first senior authorship together with safety-tool expert Toni Cathomen. Congratulations to Alieh for fantastic work! tinyurl.com/4b4f6383

🧫 Natural Killer cells are key defenders against infection and cancer.

At last month’s Stem Cell Talk, Prof. Ewa Sitnicka-Quinn shared new insights into how they develop & how this knowledge may support future NK-cell–based therapies. #NKcells

Read More:
👉 www.stemcellcenter.lu.se/research-gro...

A regulatory pathway to establish a cancer therapy platform based on #Immunotherapy , avoiding #Lymphopenia caused by chemotherapy and radiation, with full patent protection. tinyurl.com/437xrx77
#immunology #PrecisionMedicine #CancerResearch #NKcells #Lymphopenia #CARNK #immunosky

How Natural Killer cell lysate reduces the damage caused by Lymphodepletion in T-cell therapies
#immunosky #medsky #NKcells #Cancer #Cytokines

cloud.hoststar.ch/s/aecHWe5LXS...

Engineered “natural killer” cells could help fight cancer Researchers found a way to engineer CAR-NK immune cells that makes them much less likely to be rejected by the patient’s immune system, a common drawback of this type of cancer immunotherapy.

⚡ Stayed active longer than usual
💥 Avoided dangerous immune storms that sometimes affect #CAR-T therapies
A huge leap toward safer, longer-lasting cancer #immunotherapies! 🙌
#CancerResearch #Biotech #MIT #Harvard #NKCells #FutureOfMedicine

From CAR-NK cells to checkpoint inhibitors, Blunt & Khakoo review how boosting NK-cell function could transform cancer therapy.

🔓 Open access: https://bit.ly/4j8dKEW

#Immunotherapy #NKcells #CancerResearch

Concept image from Getty Images, defence against the coronavirus

A new KI study published in Nature Immunology shows that CD56bright #NKcells temporarily reside in our organs and then leave them via the lymphatic system. The results change our understanding of how the immune system works in human organs. #Immunology 🧪 news.ki.se/the-immune-s...

NK50 meeting for #NKcells @ki.se celebrating 50 years about to begin

Novel trispecific killer engager targeting B7-H3 enhances natural killer cell antitumor activity against head and neck cancer Background Patients with head and neck squamous cell carcinoma (HNSCC), particularly the human papillomavirus negative (HPV −) subset, have a dismal prognosis. Furthermore, patients with Fanconi anemi...

At today’s lab journal club, we discussed PMC12306285: a trispecific killer engager targeting B7-H3 that boosts NK cell activity against head & neck cancer, even under hypoxia.
#Immunotherapy #NKcells
#CancerResearch #ImmunoSky
jitc.bmj.com/content/13/7...

🧬 New in Immunotherapy Advances:

Cytokine-induced memory-like NK cells + Tafasitamab show strong efficacy against B-cell ALL, boosting cytotoxicity & survival in vivo.

Open Access 👉 https://bit.ly/48oztXa

#Immunotherapy #NKcells

Design of an artificial natural killer cell mimicking system to target tumour cells
Journal of Tissue Engineering
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#immunotherapy #nanomedicine #NKcells #targeteddrugdelivery #openaccess

graphical abstract of Harnessing natural killer cell effector function against cancer

💥Open Access review: NK cells as cancer fighters!

From CAR-NK cells to checkpoint inhibitors, explore cutting-edge strategies to harness NK-cell immunity. 🔬

Read: https://bit.ly/4j8dKEW

#Immunotherapy #NKcells #CancerResearch