Link to publication ⬇️
link.springer.com/article/10.1...

Gut bacteria appears linked to how much latent #HIV remains in the blood during antiretroviral therapy, a study in Gut Pathogens shows. Findings suggest the gut #microbiome may influence how much virus persists in the body 🧪
news.ki.se/gut-bacteria...

Link to publication ⬇️
bmjoncology.bmj.com/content/5/1/...

Anaemia detected in healthcare is associated with an increased risk of both cancer and higher mortality. This is shown in a new population-based study published in BMJ Oncology. The findings may help guide clinical follow-up of patients with anaemia in routine care 🧪
news.ki.se/anaemia-link...

Investigating the replicability of the social and behavioural sciences - Nature A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

Link to publications:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Illustration of a man analysing different data. Image from Getty Images.

The results of a major international collaboration on scientific reliability are presented in three articles in @nature.com. Around half of previously published research results in #SocialScience and #BehaviouralScience could not be replicated in new experiments 🧪 news.ki.se/half-of-soci...

Heart failure with reduced ejection fraction in Sweden: patient adherence and persistence to quadruple pharmacotherapy prescription AbstractBackground and Aims. Real-world uptake of heart failure with reduced ejection fraction (HFrEF) treatments relies on physician prescriptions but als

Link to publication ⬇️
academic.oup.com/eurheartj/ad...

More patients with heart failure receive the recommended four-drug therapy, but adherence and persistence still need improvement. Better adherence is linked to lower risk of hospitalisation and cardiovascular death, a new study shows in European Heart Journal 🧪
news.ki.se/more-patient...

Modified Checklist for Autism in Toddlers in a Neonatal High-Risk Population This cohort study assesses the diagnostic accuracy of the Modified Checklist for Autism in Toddlers in a neonatal high-risk population in Sweden and identifies factors associated with subsequent clini...

Link to publication ⬇️
jamanetwork.com/journals/jam...

M-CHAT does not catch all children with #autism in the neonatal high-risk group, shows a study in @jamanetworkopen.com. The researchers see a need to supplement the test with other assessment methods 🧪
news.ki.se/screening-te...

Inhibition of the type I interferon receptor pathway protects against muscle weakness induced by dermatomyositis serum Dermatomyositis (DM) is characterised by systemic inflammation, debilitating muscle weakness, cutaneous lesions, and increased mortality. An upregulation of type I interferon (IFN)-stimulated genes is...

Link to publication: ard.eular.org/article/S000...

Clue to how muscles weaken in dermatomyositis opens door to new drug treatments Factors in the blood of patients with dermatomyositis can impair muscle function by activating a specific inflammatory pathway. This is shown in a new study from Karolinska Institutet published in Ann...

Factors in the blood of patients with #dermatomyositis can impair muscle function by activating a specific inflammatory pathway, finds a KI study published in @ard.eular.org. The results suggest that drugs that block this signalling could counteract muscle weakness 🧪 news.ki.se/clue-to-how-...

Genetically diverse influenza antibodies highlight the role of IG germline gene variation and inform population-comprehensive vaccine strategies Variation in antibody genetics, as illustrated in the accompanying paper by Corcoran et al., can present a challenge to the development of population-wide protective vaccines. Fischer, Corcoran, et al...

Link to publications:
www.cell.com/immunity/ful...

doi.org/10.1016/j.im...

Large mapping of hereditary differences in the immune system Inherited variations in antibody genes can affect how we respond to infections and vaccines, show two new studies from Karolinska Institutet published in the journal Immunity. The researchers have map...

Two new KI studies published in @cp-immunity.bsky.social have mapped immune gene variation across multiple global populations and shown how these variations affect the ability to form neutralising antibodies, for example against the #influenza virus 🧪 #Immunology #Genetics news.ki.se/large-mappin...

Link to publication: doi.org/10.1016/S266...

Early initiation of treatment alleviates symptoms in rheumatism Early treatment for rheumatoid arthritis leads to significant improvements in pain, fatigue, and quality of life — regardless of whether patients receive biologic drugs or conventional therapy. This i...

Early treatment for #RheumatoidArthritis leads to significant improvements in pain, fatigue, and quality of life – regardless of whether patients receive biologic drugs or conventional therapy. New KI study published in @thelancetrheum.bsky.social 🧪 #Rheumatology news.ki.se/early-initia...

KI researchers have created a detailed map showing how genetic activity is controlled in individual cells of the adult human #brain and #spinalcord. Oligodendroglia retain an epigenetic memory of developmental programs long after these genes are no longer active 🧪 news.ki.se/new-map-reve...

In vivo site-specific engineering to reprogram T cells - Nature Stable and cell-specific transgene expression can be achieved through in vivo site-specific integration of large DNA payloads using a two-vector system of enveloped delivery vehicles and adeno-as...

Link to publication: doi.org/10.1038/s415...

Illustration of CAR-T cells that attack cancer cells. Image: Getty Images

A study published in @nature.com today presents a new method that makes it possible to generate CAR-T cells inside the body. Several types of #cancer were treated in mice without the immune cells needing to be extracted and processed in a laboratory 🧪 #immunotherapy news.ki.se/immune-cells...

A streamlined, nanopore-compatible 5PSeq protocol for rapid phenotypic antimicrobial sensitivity testing Liu et al. present s5PSeq, a rapid 4-h sequencing workflow that detects antibiotic-induced ribosome stalling within minutes to provide a molecular readout of phenotypic antimicrobial susceptibility. I...

Link to publication ⬇️
www.cell.com/cell-reports...

Researchers have developed a rapid and cost efficient sequencing method that can identify antibiotic resistance within the same working day. The technique, called s5PSeq, measures how bacterial ribosomes respond within minutes after exposure to an antibiotic 🧪
news.ki.se/rapid-sequen...

Reconstitution of the uterine immune milieu after uterus or hematopoietic stem cell transplantation Functional reconstitution of the endometrium occurs after both uterus and HSC transplantation, and male immune cells can replenish the uterine niche.

Link to publication: www.science.org/doi/10.1126/...

The uterus' immune system can regenerate after transplantation The immune system in the uterus can regenerate after both uterus transplantation and bone marrow transplantation. This is shown by a new study from Karolinska Institutet that has been published in the...

The immune system in the #uterus can regenerate after uterus or bone marrow transplantation, finds a KI study published in Science Translational Medicine. The new insights may be significant for the treatment of infertility and pregnancy complications 🧪 #Immunology news.ki.se/the-uterus-i...

Normalization of Insulin Resistance, Rather Than Hyperglycemia, Before Stroke Improves Functional Outcomes in a Mouse Model of Type 2 Diabetes Prestroke hyperglycemia and insulin resistance (IR) independently correlate with poor stroke outcomes in type 2 diabetes (T2D), although their causative ef

Increasing insulin sensitivity prior to a #stroke leads to better functional recovery than focusing on blood-sugar control alone in #diabetes, finds a new study in mice, published in the journal Diabetes @adapubs.bsky.social by researchers at Karolinska Institutet 🧪 doi.org/10.2337/db25...

Efficient sampling of large-scale transition pathways and intermediate conformations in sub-mesoscopic protein complexes - PubMed Protein conformational changes are the cornerstone of biological function. While conformers captured experimentally represent metastable states, the pathways connecting them have been elusive for experiments and simulations alike. Nowadays, cryogenic Electron Microscopy is providing rich structural …

Link to publication ➡️
pubmed.ncbi.nlm.nih.gov/41771853/

Researchers have developed a computational method capable of simulating the movements of some of the cell’s largest protein complexes. The study is published in @natcomms.nature.com 🧪
news.ki.se/simulations-...

Neuropsychiatric symptoms in preclinical and clinically manifest dementia: clusters and their health determinants INTRODUCTION Neuropsychiatric symptoms (NPSs) are common in dementia, but their patterns in preclinical stages remain unclear. This study identified NPS clusters and associated health factors in a g...

Link to publication ➡️
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Behavioural changes may appear long before a dementia diagnosis. A new study published in @alzdemjournals.bsky.social, shows that these symptoms form recognizable patterns across older adults ranging from cognitively unimpaired to those with dementia 🧪
news.ki.se/behavioural-...

Time-dependent adaptations of damaged neurons and their microenvironment in the regenerating adult zebrafish spinal cord Spinal cord healing in zebrafish depends on a perfectly timed interaction between neurons and their microenvironment.

Link to publication: www.science.org/doi/10.1126/...

Timing found to be crucial for spinal cord repair in zebrafish The healing of the spinal cord depends on carefully timed interactions between injured nerve cells and their surrounding environment, according to a new study published in Science Advances by research...

The healing of the spinal cord depends on carefully timed interactions between injured nerve cells and their surrounding environment, according to a new study on zebrafish published in Science Advances by KI researchers 🧪 #SpinalCordInjury #neuroscience news.ki.se/timing-found...