however, RSV often exhibits ⏫️ lymphocyte counts, whereas #COVID presents with #lymphopenia
Prior work has shown that young children with mild RSV disease had greater induction of interferon & plasma cell genes & decreased expression of inflammation , neutrophil genes vs with those with severe RSV

The maturation process of lymphocytes and how Anktiva, an IL-15 superagonist, enhances these processes A comprehensive, step-by-step summary of the key processes in Immunology 2.0 and their potential to transform standard cancer care.

Why are lymphocytes often neglected in cancer treatment, and what changes are necessary?
huggenberg.substack.com/p/fundamenta...
#Immunotherapy #PrecisionMedicine #CancerResearch #NKcells #Lymphopenia #CARNK #immunosky

The roles of macrophages and monocytes in COVID-19 Severe Respiratory Syndrome The global COVID-19 pandemic has highlighted the pivotal role of the immune system in the development of severe respiratory symptoms, termed COVID-19 …

🧨 Patterns of #Lymphocyte Subset Changes
- While total #lymphocyte counts generally return to normal in most patients who had mild to moderate #COVID , a subgroup, particularly those with severe disease, can experience persistent #lymphopenia

www.sciencedirect.com/science/arti...

1. Activation induced apoptosis & #Tcell exhaustion
- The robust activation CD8+ T cells alongside unaltered TREC ( #Tcell Receptor excision circle) levels suggests that activation induced #apoptosis plays an important role in the long-term #lymphopenia.

- #Lymphopenia & #Tcell depletion are often reversed upon patient recovery, with restored #Tcell counts & decreased cytokine levels
- #COVID infection & vaccination can induce memory T cell responses, which are important for long-term immunity.

#COVID infection is associated with significant changes in #Tcell populations
- #Lymphopenia: A marked reduction in both CD4+ & CD8+ T cells is observed in COVID patients, with some studies indicating that CD8+ T cells are more affected, while others report a greater impact on CD4+ T cells

A regulatory pathway to establish a cancer therapy platform based on #Immunotherapy , avoiding #Lymphopenia caused by chemotherapy and radiation, with full patent protection. tinyurl.com/437xrx77
#immunology #PrecisionMedicine #CancerResearch #NKcells #Lymphopenia #CARNK #immunosky

- A hallmark of severe #COVID is #lymphopenia, a significant reduction in the total number of #lymphocytes in the peripheral 🩸.This decrease is more pronounced & persistent in critically ill patients, making it a strong predictor of a fatal outcome.
-The drop in T-lymphocytes

FDA authorizes Expanded Access Program of Anktiva for lymphopenia The Cancer BioShield platform is being assessed as a treatment for lymphopenia in adult patients with refractory or relapsed solid tumors, including genitourinary tumors.

The FDA has authorized an Expanded Access Program for Anktiva (NAI) to tackle lymphopenia in patients with relapsed or refractory solid tumours! #TCSC #FDA #CancerTreatment #Anktiva #Immunotherapy #Lymphopenia #OncologyNews #ClinicalTrials #CancerResearch

www.urologytimes.com/view/fda-aut...

The transformation from #cancercare towards #Immunotherapy with a therapeutic #CancerVaccine across multiple tumor types.

#Lymphopenia #antibody_fusion_protein #NKcells

immunitybio.com/founders-vis...

Anktiva as a lymphocyte rescue molecule: Unlocking the power of NK cells and T cells "One way to think about how Anktiva works is it is the first molecule, based on the package insert, that increases and proliferates the NK cells, the T cells, and the CD4+ and CD8+ T cells, without up...

New blood test routine:
Anemia —> Epogen
Neutropenia —> Neupogen
Lymphopenia —> Anktiva
#Immunotherapy #antibody_fusion_protein #NKcells #Lymphopenia #CARNK

#Anktiva mechanism of action

www.urologytimes.com/view/anktiva...

ImmunityBio Receives FDA RMAT Designation for ANKTIVA® and CAR-NK for the Reversal of Lymphopenia in Patients Receiving Standard-of-Care Chemotherapy/Radiotherapy and in Treatment of Multiply Relapsed... Regenerative Medicine Advanced Therapy (RMAT) designation follows clinical data of Absolute Lymphocyte Count (ALC) and significant Overall Survival (OS) correlations in QUILT trials across multiple tu...

Former blood test routine:
Anemia —> Epogen
Neutropenia —> Neupogen

New blood test routine:
Anemia —> Epogen
Neutropenia —> Neupogen
Lymphopenia —> Anktiva

#Immunotherapy #antibody_fusion_protein #NKcells #Lymphopenia #CARNK

ir.immunitybio.com/news-release...

2020

The haematological manifestations of COVID-19 include blood count anomalies notably #lymphopenia and neutrophilia which are of prognostic significance ..
doi: 10.1111/ejh.13491

fascinating that a new platform hosts the same controversial actors
💁
isn't it simplistic to say ZC folks are wrong bc they are covid cautious
reminding that we know nothing about longterm effects & immune dysregulation impact after 10 years?
🤷
#lymphocytopenia #lymphopenia after #SARSCOV2 infection

#Homelessness #precarity
#CovidIsNotOver
#challenge #InfectiousDiseases
#SARSCoV2 is immuno dysregulative #lymphopenia

www.merckmanuals.com/professional...

#lymphopenia #fungi
endemic #SARSCoV2 consequences

bsky.app/profile/tage...

Ihr habt vergessen #SARSCoV2 zu erwähnen

#lymphopenia #Covid #fungi

"Wer ist besonders gefährdet?

Bisher sind in erster Linie Menschen mit einem reduzierten Immunsystem von Pilzinfektionen betroffen"

eben solche mit #LongCovid

@yaneerbaryam.bsky.social
Look 👇

Acquired Immune Deficiency Syndrome correlation with SARS-CoV-2 N genotypes Epigenetics and clinical observations referring to Betacoronavirus lead to the conjecture that Sarbecovirus may have the ability to infect lymphocytes…

#lymphopenia
#SarsCov2
#covid
#longcovid

2022 data,publication 2024

www.sciencedirect.com/science/arti...

I don't like official
🇩🇪 narratives that we have hybridimmunity now,bc #corona is endemic now & we should get infected for herdimmunity

😳
this is insane!

catch this as less as possible!

Lymphopenia in sepsis: a narrative review - Critical Care This narrative review provides an overview of the evolving significance of lymphopenia in sepsis, emphasizing its critical function in this complex and heterogeneous disease. We describe the causal re...

#MedSky🧪#IDSky #ICU Understand the causal relationship of #lymphopenia with clinical outcomes, sustained immunosuppression, & its correlation with #sepsis prediction markers and therapeutic targets.

ccforum.biomedcentral.com/articles/10....

How does SARS-CoV-2 cause lymphopenia when T cells barely express ACE-2 receptors? Researchers reveal both direct and indirect mechanisms of SARS-CoV-2-induced lymphopenia, highlighting the role of CD147 and alternative viral entry routes into T cells.

How does SARS-CoV-2 cause lymphopenia when T cells barely express ACE-2 receptors? 🔬🦠📊 www.news-medical.net/news/2024070... #COVID19 #SARSCoV2 #TCells #Lymphopenia #Immunology #CD147 #CytokineStorm #ViralInfection #MedicalScience

#MedSky🧪#IDSky #Viralimmunology #ImmunoSky #Tlymphocytes play a primary role in the #Adaptiveimmunity .Both #lymphocytosis & #lymphopenia were found to be associated with severe #SARSCoV2