This review maps the genetic landscape of #AnaplasticThyroidCancer, spotlighting #MAPK & PI3K-AKT-mTOR signaling to connect pathogenic mechanisms with advances in targeted therapies, #immunotherapies, and diagnostic development.

#OpenAccess: doi.org/10.1016/j.ge...

Five projects share £100m UK-US Cancer Grand Challenges fund Five scientific teams will receive up to £20m each in a new round of funding under the UK and US Cancer Grand Challenges initiative.

#CancerGrandChallenges #CRUK #NCI #UK #USA #oncology #cancer #ATLAS #INSERM #autoantibodies #tumours #REWIRECAN #UCLCancerInstitute #ILLUMINE #NetherlandsCancerInstitute #darkproteome #proteins #immunotherapies #antigenicmarkers #CAUSE #InteroCANCEption #FrancisCrickInstitute
zurl.co/P9eTF

Researchers show dual-target CD19/CD22 #CARTTherapy plus ASCT achieves durable survival in #TP53-mutated r/r aggressive #BNHL, offering curative potential with consistent long-term safety and paving the way for next-gen #immunotherapies.

#OpenAccess in #STTT: doi.org/10.1038/s413...

👉 Stay ahead of emerging #toxicity challenges in next‑gen #immunotherapies. Get insights from experts and join the live Q&A.

🔗 Register now and earn 1 ESMO-MORA point: https://ow.ly/HMns50YcO6k

#ESMOOnAir #ESMOWebinars

Scientists found a sugar that could defeat deadly superbugs Scientists in Australia have uncovered a clever new way to fight some of the most dangerous drug-resistant bacteria by targeting a sugar that exists only on bacterial cells. By designing antibodies…

"The team engineered #antibodies that lock onto a sugar found only on bacterial #cells, an approach that could support a new generation of #immunotherapies for multidrug resistant #infections acquired in #hospitals.": buff.ly/fPqV1cV

via sciencedaily
#antibiotics #medicine #PublicHealth #research

New study paves way for immunotherapies tailored for childhood cancers | Imperial News | Imperial College London New research shows how children’s immune systems react differently to cancer than adult immune systems.

One-size-fits-all #cancer treatment doesn’t work for children. ‼️

A major study led by @mrc-lms.bsky.social shows childhood cancers interact with the immune system in unique ways – helping pave the way for tailored #immunotherapies.

www.imperial.ac.uk/news/260116/...

🧵 6/6

A yeast surface display platform for characterizing CAR T cell responses to cancer antigens - Nature Communications Chimeric antigen receptor T (CAR-T) cell therapy uses engineered donor T cells to recognize and eliminate cancer cells through cognate antigen-dependent activation. Here authors develop an alternative...

In a new study, researchers developed a new yeast surface display technology that makes it possible to test & understand advanced #cancer treatments. It has the ability to reduce development time for cancer #immunotherapies from months to days or weeks.
www.nature.com/articles/s41...

Unmasking Cancer: The Economics of Glycan-Targeting Immunotherapies and the Future of Immune Recognition Recent advances in cancer immunotherapy have revealed a previously under-theorised mechanism of tumour immune evasion: the construction of glycan-based "su

Unmasking #Cancer: The #Economics of Glycan-Targeting #Immunotherapies and the Future of #Immune Recognition :: #SSRN share.google/hUcBpzCIFteH...

ErVimmune raises 17m euros in funding to develop cancer vaccine - PharmaTimes The vaccine could be created as a ready-to-use product, rather than needing to be personalised

#vaccinedevelopment #ErVimmune #biotech #cancervaccine #readytousevaccine #personalisedvaccines #celltherapies #cancervaccines #cancervaccinecandidate #ErVac01 #immunotherapies #coldtumours #triplenegativebreastcancer #ovariancancer #offtheshelfcancervaccine #difficulttotreatcancers
zurl.co/Z94ou

OSF

OSF | Unmasking #Cancer: The #Economics of #Glycan Targeting #Immunotherapies and the Future of Immune Recognition. #OSF Open Science Framework share.google/EN8ahivf1sfg...

Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia

Relapsed #AML drives #NKCell exhaustion via the NKG2A/HLA‑E axis and PI3K‑AKT suppression; blocking NKG2A or restoring #AktPhosphorylation enhances #cytotoxicity, highlighting a strategy to optimize NK cell‑based #immunotherapies. @pku1898.bsky.social

#STTT: doi.org/10.1038/s413...

Using the SpyTag/SpyCatcher system, researchers developed anti-#Mesothelin (MSLN) uCAR-like NK cells with enhanced tumor penetration, establishing a promising therapeutic strategy for #Immunotherapies targeting MSLN-positive #SolidTumors.

#OpenAccess: doi.org/10.1038/s413...

NEW STUDY: #Tcells residing in tissues i.e. #tonsils differ significantly from T cells circulating in the #blood. This challenges assumptions in #immunology and could transform how we assess immune responses to #vaccines #infections #immunotherapies.

www.linkedin.com/posts/drmelv...

We are excited to announce #NDLR2026 speaker Professor Joy Ho. Joys' work focuses on benign and malignant haematology, particularly #myeloma, #lymphoma, and #immunotherapies. She leads multi-centre #ClinicalTrials, introducing new therapies to Australia and improving patient outcomes.

🧠 #EANM #FocusMeeting7 – 𝗧𝗿𝗮𝗰𝗸 𝟯 𝗣𝗿𝗲𝘃𝗶𝗲𝘄

Regulatory approval of #amyloid-lowering #immunotherapies in #Alzheimer’s disease: should clearcut biomarker evidence be the deciding factor?

➡️ Be part of the discussion:

Online today! 👉 Dynamics of checkpoint receptors in #γδTcell subsets are associated with clinical response during anti-PD-1 #immunotherapies

By E. Catafal-Tardos, @vasgdtcells.bsky.social & colleagues at Technical University of Denmark

🗞️ doi.org/10.1038/s443...

Episode 168: New Immunotherapies for Community Teams and Non Oncologists Part 2 with Macmillan GP Lead for Wales Dr Elise Lang

This weeks Immunobuddies episode is out now, get listening!! 🎙️Episode 168: New #Immunotherapies for Community Teams and Non Oncologists Part 2 with Macmillan GP Lead for Wales Dr Elise Lang open.spotify.com/episode/5B8n... @rickyfrazer1.bsky.social @velindrecc.bsky.social #Cancer

Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall.

A new #ScienceImmunology study in mice has identified stem-like tissue-resident memory T cells that can reactivate and regulate immune responses in the intestines, which could inform future #immunotherapies against gastrointestinal tumors or chronic infections. https://scim.ag/4hJTaeH

#ESMO25: Early results with two novel #immunotherapies in advanced neuroendocrine carcinoma (#NEC) suggest greater efficacy versus chemotherapy alone but with higher toxicity #ESMODailyReporter 🔗 https://ow.ly/I4x150XjCwR

#RareCancers

Engineered “natural killer” cells could help fight cancer Researchers found a way to engineer CAR-NK immune cells that makes them much less likely to be rejected by the patient’s immune system, a common drawback of this type of cancer immunotherapy.

⚡ Stayed active longer than usual
💥 Avoided dangerous immune storms that sometimes affect #CAR-T therapies
A huge leap toward safer, longer-lasting cancer #immunotherapies! 🙌
#CancerResearch #Biotech #MIT #Harvard #NKCells #FutureOfMedicine

Design of a potent interleukin-21 mimic for cancer immunotherapy A de novo IL-21 mimic, 21h10, exhibits improved stability and potent antitumor activity in vivo compared with native IL-21.

Scientists have designed an interleukin-21 mimic with increased stability and capacity to induce more potent antitumor activity than the native protein, which could inform improved #immunotherapies.

Learn more in #ScienceImmunology: https://scim.ag/47jQLSW

⚡Can light could be used to manipulate tumour-associated bacteria?🦠Find out how Prof Anguraj Sadanandam, Dr Jang Ah Kim and @jameskinross.bsky.social from @icr.ac.uk and @imperialsandc.bsky.social are investigating how this could make #immunotherapies safer and more effective.
#ConvergenceScience

New insights into the control of the immune system Find out more!

🧬 New insights into the control of the #immunesystem:

The protein TRAT1 acts as a switch between defence and self-regulation – and could be a new starting point for cell-based #immunotherapies.

Researchers at #MedUniVienna show how T helper cells maintain the balance between attack & control. ⬇️

This review highlights the multifaceted mechanisms of #tumor #ImmuneEvasion, including checkpoint regulation, #TumorMicroenvironment dynamics & #MetabolicReprogramming, while discussing emerging #immunotherapies to curb resistance.

#STTT #OpenAccess: doi.org/10.1038/s413...

Just 1 month to go! 🤩 At #ImmaginaRNA25, we’ll welcome Kfir Oved, CEO & Founder of Canopy Immuno-Therapeutics, sharing how Antigen-Drug Conjugates (AgDCs) could transform autoimmune disease treatment. Don’t miss it—register now! zurl.co/Cnp5j
#ribosome #RNA #immunotherapies

Ménard, Yoda, Weiss et al. show that myeloid-targeting #immunotherapies overcome inhibitory barriers in immune-evasive #neuroblastoma. rupress.org/jem/article/...

📘 #Macrophages and #DendriticCells in Health and Disease 👉 rupress.org/jem/collecti...

Targeting IFNγ-mediated #pyroptosis reverses PA-induced downregulated antitumor immunity of γδ-T cell antitumor immunity, while dietary OA improves responsiveness to Vγ9Vδ2-T cell-based #immunotherapies. #medsky

New study in #STTT #OpenAccess: doi.org/10.1038/s413...

Ready to learn about the Cure & Immunotherapies Think Tank? ✋

This team develops and tests targeted #immunotherapies and therapeutic vaccines to decrease viral reservoirs and find cures for HIV and #HepB, and vaccines for syphilis, HPV, and hep C.

Learn more: 
https://bit.ly/472j75z

through genetic, autoantibody-mediated processes, complementing previous principles learned from animal studies & iatrogenic contexts. Improved understanding of human immunity to fungal diseases will facilitate the development of host-directed #immunotherapies & targeted public health interventions

Experience a day in the life as center trainee Christopher Ochoa, a UCLA PhD candidate developing novel #immunotherapies to target aggressive gynecologic cancers in the lab of Dr. Sanaz Memarzadeh. 🏋🏽👨🏽‍🔬🧫

#OvarianCancer #EndometrialCancer #StemCellResearch