🎬 La Minute de l’Inflammation – Épisode 1 : la voie NF-κB

la voie NF-κB, un mécanisme clé qui déclenche l’inflammation et peut dérailler en cas de dysfonctionnement.

▶️ www.youtube.com/watch?v=-DhU...

#Inflammation #Immunologie #NFkB #VulgarisationScientifique #RechercheMédicale

🩸Facts about Myelofibrosis:

Combination & Emerging Therapies

#Myelofibrosis #HemeOnc #Hematology #MedEd #ClinicalTrials #Epigenetics #Pelabresib #Ruxolitinib #JAKInhibitors #Selinexor #NFkB #Cytokines #HemeHub #HematologyEducation #MedicalEducation

🩸Facts about Multiple Myeloma:

Myeloma Biology and Microenvironment

#MultipleMyeloma #Hematology #NKcells #Cytogenetics #HEMEHUB #TP53 #NFkB #Hyperdiploidy #t1114 #del17p #HemOnc #MedEd

Decoding the Role of NF-κB Signaling in COVID-19 Severity and Inflammation - Premier Science COVID-19, nf-κb signalling, inflammation, Toll-like receptor activation, Non-canonical nf-κb pathway, Cytokine storm, nf-κb inhibitor docking.

doi.org/10.70389/PJS...

#NFkB #covid #covid19 #covid #inflammation

#ESM1 or #Endocan or #endothelial cell specific molecule 1: a key knot (with #HomoCysteine & #NFKB) of the #metabolic #pathway for #human #health.
Public Open Question .. www.researchgate.net/post/Homocys...

Paper TEXT .. www.researchgate.net/post/Homocys... ........

Separation-of-function mutants reveal the NF-κB-independent involvement of IκBα in the regulation of intestinal stemness Daniel Álvarez-Villanueva et al. dissect distinct roles of the NF-κB inhibitor IκBα by generating separation-of-function mutants. Their findings reveal that chromatin-bound IκBα, independent of NF-κB ...

Very happy to have our latest work on how IκBα regulates stemness independently from NF-κB. It has been a terrific collaborative work led by Lluís Espinosa and Daniel Alvarez-Villanueva @researchmar.bsky.social

#nfkb #ikb #inflammation #stemcells

www.cell.com/cell-reports...

Synergy and antagonism in the integration of BCR and CD40 signals that control B-cell proliferation In response to infection or vaccination, a successful antibody response must enrich high-affinity antigen-reactive B-cells through positive selection, but eliminate auto-reactive B-cells through negat...

B-cell decisions depend on signal timing ⏱🧬🔁
Modeling reveals how BCR & CD40 cues shape immune fate.
#Immunology #Bcells #NFkB

Study from the Hoffman lab @uofcalifornia.bsky.social

🆕 #preprintpeerreview by @reviewcommons.org

Reviews and author's response 👇

doi.org/10.1101/2024...

🕰️Can #circadianrhythms protect or harm your #βcells?

New #iScience study shows clock syncing changes response to #cytokines in INS-1 vs. mouse islets. Big impact on #NFkB, #cellDeath & #inflammation!

🧾Read more: www.cell.com/iscience/ful...
#Chronobiology #DiabetesResearch #MolecularBiology #Islet

The Drosophila Immunity Handbook cover, showing flies that are either glowing green or not. All flies are infected by a green-expressing bacteria, but only red-eyed flies glow green because those flies are missing immune genes needed for resistance to infection.

Some hashtags:

#immunity #Dros25 #Drosophila #antimicrobialpeptides #NFkB #inflammation #ImmunoSky #Infection #pathogen

And if you want to learn more about these modules and how you could incorporate them in your research, check our our free book: "The Drosophila Immunity Handbook"
bit.ly/3z429p5

Social disadvantage accelerates aging Nature Medicine - Individuals with social disadvantage, during both early and later life, have an increased risk of 66 age-related diseases mediated by 14 age-related proteins.

This multicohort study links social disadvantage to accelerated ageing, highlighting NF-κB activation as a key underlying mechanism.

#Aging #SocialDeterminants #NFkB

rdcu.be/edyqo

🔬 Meet the Researchers Behind IMMERGE! 🔬

This week: Emily Flaschner & Dr. @jlsardinalab.bsky.social from @carrerasijc.bsky.social!
Emily's research explores TET-mediated epigenetic control in NF-κB mutated patients👩‍🔬🌟

Stay tuned for more IMMERGE scientists! 🚀

#IMMERGE #MSCA #Epigenetics #NFkB #IEI

Ruscogenin Ameliorated Sjögren's Syndrome by Inhibiting NLRP3 Inflammasome Activation This article investigated the role and the specific mechanism of Ruscogenin in Sjögren's syndrome (SS). NOD/ShiLtJ mice were treated with Ruscogenin, and acinar cells isolated from submandibular gland...

Has anyone tried Ruscogenin to treat Sjogren's? I see all the indicators it should work: blocks #TLR4, #NLRP3, #MYD88, #NfKB, #P2X7R, #TNF-A and #IL-1B activation, and has been shown in mouse models to ameliorate #Sjogren's

pmc.ncbi.nlm.nih.gov/articles/PMC...

Thrilled to share our latest in @jem.org! 🚨
A single patient with syndromic immunodeficiency led us to uncover that biallelic point mutations in the IKKα kinase domain disrupt the non-canonical and partially the canonical NF-kB pathway activation. Dive into the details! 🧬 #NFkB #Immunology

CH-3 and #DMF/#tecfidera disp comparable capacity to activate #Nrf2 and downstream transcripts, but with less off-target effects on #HIF1 and #NFkB from CH-3. This was repeated in #microglia, #oligodendrocytes & in vivo #MS #TBI #neurodegeneration #redox