MyD88 determines T cell fate through BCAP-PI3K signaling Abstract. The life cycle of effector T cells is determined by signals downstream of the T cell receptor (TCR) that induce activation and proinflammatory ac

Data demonstrated that MyD88 acts downstream of the T-cell receptor to regulate T cell fate implying a molecular mechanism for #MyD88 in T cell biology that could be targeted to fine-tune T cell effector function and survival therapeutically. Read more: ow.ly/yPEs50VGr17

Ruscogenin Ameliorated Sjögren's Syndrome by Inhibiting NLRP3 Inflammasome Activation This article investigated the role and the specific mechanism of Ruscogenin in Sjögren's syndrome (SS). NOD/ShiLtJ mice were treated with Ruscogenin, and acinar cells isolated from submandibular gland...

Has anyone tried Ruscogenin to treat Sjogren's? I see all the indicators it should work: blocks #TLR4, #NLRP3, #MYD88, #NfKB, #P2X7R, #TNF-A and #IL-1B activation, and has been shown in mouse models to ameliorate #Sjogren's

pmc.ncbi.nlm.nih.gov/articles/PMC...

A MicroED structure of the MAL TIR-mediated MyD88 TIR higher-order assembly reveals a two-stranded arrangement of TIR domains similar to MAL TIR self-assemblies #MicroED #MyD88 #TIRDomain t.co/K0Jt3tVITD