BridGene Biosciences Welcomes Nobel Laureate Bruce A. Beutler to Scientific Advisory Board for Drug Innovation #United_States #San_Jose #BridGene_Biosciences #Bruce_A._Beutler #TLR4
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Maternal LPS exposure disrupts offspring gut motility: TLR4–PIEZO1 interaction enhances 5-HT–mediated dysfunction, revealing a novel inflammation-mechanotransduction link.
#GutHealth #TLR4 #PIEZO1 #InflammationResearch #Neurogastroenterology
www.sciencedirect.com/science/arti...
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078 - How I am going to fight brain inflammation | Jarred Younger, PhD
uploaded 2025-11-17
youtu.be/KpsK6RmqLNI
Dr. Younger shares his plan to manufacture and test dextro-naltrexone in a clinical trial.
😀
#naltrexone #LDN #DextroNaltrexone #neuroinflammation #neuroscience #immunology #MECFS #TLR4
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Repetitive transcranial magnetic stimulation alleviates glial activation through suppressing HMGB1/TLR4 pathway in a rat model of Parkinson’s disease [2023]
doi.org/10.1007/s110...
#Parkinsons #rTMS #TLR4 #neuroinflammation
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👏 1st Site Visit Completed for A-TANGO's #ClinicalTrial: Thanks to big efforts by Yaqrit + Royal Free Hospital, we have kicked off our Phase 2a trial, evaluating the safety of #TLR4 antagonist in combination with #G-CSF for the treatment of #ACLF!
#BenchToBedside #cirrhosis
@rajivjalan.bsky.social
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Medication info form for Low Dose Naltrexone (LDN)
For future reference, this image of the document provided with my LDN prescription explains that gluten should be avoided "...in order to achieve the full efficacy of LDN on the immune system..."
#LDN #CFS #TLR4 #LowDoseNaltrexone #GlutenFree
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Over 1 billion people in areas endemic for #leishmaniasis are at risk, reported by @who. Mazumder et al. suggest that silencing toll-like receptor #TLR4 in #macrophages could prevent parasite entry. Read more here: buff.ly/ErazuYv #PathogDis
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LPS exposure during pregnancy affects #IntestinalMotility in offspring mice by activating #TLR4 pathways in the colon. This activation, upon interaction with #PIEZO1, causes calcium influx and increases 5-HT secretion from enterochromaffin cells. #medsky
#OpenAccess:
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LPS exposure during pregnancy affects #IntestinalMotility in offspring mice by activating #TLR4 pathways in the colon. This activation, upon interaction with #PIEZO1, causes calcium influx and increases 5-HT secretion from enterochromaffin cells. #medsky
#OpenAccess:
buff.ly/Ib6xt0R
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🌟 POSTER THU-182 by Supachaya S. (UCL, @rajivjalan.bsky.social) featured in a #PosterTour at #EASLCongress! 👏
👉 Transcriptomic & metabolic insights into #hyperammonemia: The complementary therapeutic roles of #TLR4 inhibitor (#TAK242) + ornithine phenylacetate
👍 In A-TANGO, we use #TAK242 + G-CSF
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📣 Another top-notch #poster at the very heart of A-TANGO is THU-180-YI by Supachaya Sriphoosanaphan, UCL
👉 #TLR4 inhibition restores cytochrome C oxidase mitigating #hyperammonemia-induced hepatocyte mitochondrial dysfunction
#Cirrhosis & Complications
#ACLF #LiverFailure
@rajivjalan.bsky.social
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📣 Two fantastic #posters today - visit them before 5 pm! Both by Supachaya Sriphoosanaphan, UCL
👉 THU-182
Transcriptomic and metabolic insights into #hyperammonemia: the complementary therapeutic roles of #TLR4 inhibitor and ornithine phenylacetate
👉 #Cirrhosis & Complications
#ACLF #LiverFailure
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Antje Blumenthal and coworkers at the University of Queensland show that #TLR4 #endocytosis and endosomal TLR4 #signaling in #macrophages are distinct and independent outcomes of TLR4 activation. #immunity #immunology
-> www.embopress.org/doi/full/10....
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The implication of dendritic cells in lung diseases: Immunological role of toll-like receptor 4
This review discusses the critical role of #TLR4 in #DendriticCells in immune-related lung diseases, including pneumonia, pulmonary tuberculosis, asthma, acute lung injury, and lung cancer and provides clues for the development of new clinical strategies. #medsky
#OpenAccess: buff.ly/vIXHCDP
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Has anyone tried Ruscogenin to treat Sjogren's? I see all the indicators it should work: blocks #TLR4, #NLRP3, #MYD88, #NfKB, #P2X7R, #TNF-A and #IL-1B activation, and has been shown in mouse models to ameliorate #Sjogren's
pmc.ncbi.nlm.nih.gov/articles/PMC...
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Toll-like receptor-mediated innate immunity against herpesviridae infection: a current perspective on viral infection signaling pathways #EBV #CMV #KSHV #HSV1 #HSV2 #VZV #HHV6 #TLR2 #TLR3 #TLR4 #TLR5 #TLR7 #TLR9
bsky.app/profile/rene...
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Tirzepatide attenuates lipopolysaccharide-induced left ventricular remodeling and dysfunction by inhibiting the #TLR4 / NF-kB / NLRP3 pathway #MECFS #LongCovid
pubmed.ncbi.nlm.nih.gov/37196559/
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