Mitochondrial electron transport chain modulation orchestrates divergent TLR3 and TLR7 responses Manipulating the electron flow from Complexes I/II of the electron transport chain can alter the type of macrophage viral immune responses via shifting PKM

New data from Mary-Elizabeth Sheridan, Duale Ahmed and colleagues from the lab of Edana Cassol @carleton.ca - "Mitochondrial electron transport chain modulation orchestrates divergent #TLR3 and #TLR7 responses"

TLR expression and NK cell activation after human yellow fever vaccination The yellow fever vaccine is very effective with a single injection conferring protection for at least 10 years. Recent evidence suggests that the inna…

www.sciencedirect.com/science/arti...

"Shortly after vaccination, we observed increased expression of #TLR3 and #TLR9 in NK cells and markers such as CD69, HLA-DP-DQ-DR, CD38 and CD16."

Nuclear translocation of #TLR3 in #PancreaticDuctalAdenocarcinoma under #chemotherapy stress drives invasion, proliferation & #chemoresistance via JAK1/PRMT5/c-Myc axis, predicting poor prognosis and highlighting a novel therapeutic target in #cancer.

#STTT: doi.org/10.1038/s413...

Researchers identify nuclear translocation of #TLR3 under #chemotherapy stress drives PRMT5–c‑Myc signaling; high nuclear TLR3 predicts poor prognosis, highlighting the JAK1/TLR3/PRMT5/c‑Myc axis as a potential therapeutic target in #cancer.

#CoverPage #STTT: doi.org/10.1038/s413...

De novo design of protein minibinder agonists of TLR3 - Nature Communications This study reports the computational design of miniprotein binders of the pattern recognition receptor TLR3. When oligomerized, the miniprotein binders induce TLR3 signaling in cells, suggesting they ...

De novo design again 🤘 🧪 🖥️ #NoEmoji4Proteins #science #proteins #denovo #design #TLR3 www.nature.com/articles/s41...

Toll-like receptor-mediated innate immunity against herpesviridae infection: a current perspective on viral infection signaling pathways #EBV #CMV #KSHV #HSV1 #HSV2 #VZV #HHV6 #TLR2 #TLR3 #TLR4 #TLR5 #TLR7 #TLR9

bsky.app/profile/rene...

Toll-like receptor-mediated innate immunity against herpesviridae infection: a current perspective on viral infection signaling pathways #EBV #CMV #KSHV #HSV1 #HSV2 #VZV #HHV6 #TLR2 #TLR3 #TLR4 #TLR5 #TLR7 #TLR9

bsky.app/profile/rene...

Toll-like receptor-mediated innate immunity against herpesviridae infection: a current perspective on viral infection signaling pathways #EBV #CMV #KSHV #HSV1 #HSV2 #VZV #HHV6 #TLR2 #TLR3 #TLR4 #TLR5 #TLR7 #TLR9

virologyj.biomedcentral.com/track/pdf/10...

Ximena's review is out, congratulation!
Toll-Like Receptor 3 in #Solid #Cancer and #Therapy #Resistance
by Ximena Maria Muresan, Jan Bouchal, Zoran Culig and Karel Souček
👉
#TLR3
#dsRNA
#Cytokines
#therapyresistance

mdpi.com/2072-6694/12/1…