Facebook When this happens, it's usually because the owner only shared it with a small group of people, changed who can see it or it's been deleted.

This member digs the Predator sticker that came with the TLR-7 they got for their Hellcat. #PredatorSticker #TLR7

Novel #TLR7 gain-of-function variant and review of the associated disease spectrum. New study from Maud Tusseau, Claire Desvignes, Anne-Laure Mathieu, Alexandre Belot et al. @ciri-lyon.bsky.social @inserm.fr: rupress.org/jhi/article/...

@esidsociety.bsky.social
#InbornErrorsOfImmunity #Lupus

New @jhumimmunity.org from Tusseau, Desvignes, Belot et al. @ciri-lyon.bsky.social: Novel TLR7 GOF variant (P435S) causing early onset #lupus with #neuroinflammation. Functional validation & review of all known #TLR7 GOF cases. A new dive into TLR7 mediated #autoimmunity. rupress.org/jhi/article/...

New from Tusseau, Desvignes, Belot et al. @ciri-lyon.bsky.social: Novel TLR7 GOF variant (P435S) causing early onset #lupus with #neuroinflammation. Functional validation & review of all known #TLR7 GOF cases. A new dive into TLR7 mediated #autoimmunity. rupress.org/jhi/article/...

#InnateImmunity

🔥Hot Off the Press | PLD4 mutations→ #SLE
This #Nature study (Qintao Wang et al.) identifies recessive #PLD4 loss-of-function mutations in SLE, revealing its key role in immune balance. PLD4 loss→ ssNA buildup→ #TLR7 /#TLR9 overactivation → #IFN surge→ autoantibodies→ SLE.

Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement Recognition of exogenous RNA by Toll-like receptors (TLRs) is central to pathogen defense. Using two distinct binding pockets, TLR7 and TLR8 recognize…

#WeekendRead! #ToSenseOrNotToSense! #MysterySolved! Berouti, Wagner, Carell, @v-hornung.bsky.social &co show @cp-cell.bsky.social that RNase T2 & PLDs generate #TLR7 & #TLR8 agonistic ligands only if RNA does not contains pseudouridines explaining avoidance of self RNA sensing!

Somatic gain-of-function mutation in TLR7 causes early-onset systemic lupus erythematosus We identified a case of early-onset systemic lupus erythematosus (SLE) characterised by acute immune thrombocytopenia, recurrent fever, pneumonia, myo…

www.sciencedirect.com/science/arti...
“We report early-onset #SLE caused by a somatic #TLR7 gain-of-function mutation. Our findings demonstrate that the TLR7 F506S mutation drives excessive proinflammatory signalling in the patient's PBMCs, contributing to disease pathogenesis.”
#Rheumsky #lupus 🦋

Toll-like receptor-mediated innate immunity against herpesviridae infection: a current perspective on viral infection signaling pathways #EBV #CMV #KSHV #HSV1 #HSV2 #VZV #HHV6 #TLR2 #TLR3 #TLR4 #TLR5 #TLR7 #TLR9

bsky.app/profile/rene...

Toll-like receptor-mediated innate immunity against herpesviridae infection: a current perspective on viral infection signaling pathways #EBV #CMV #KSHV #HSV1 #HSV2 #VZV #HHV6 #TLR2 #TLR3 #TLR4 #TLR5 #TLR7 #TLR9

bsky.app/profile/rene...

Toll-like receptor-mediated innate immunity against herpesviridae infection: a current perspective on viral infection signaling pathways #EBV #CMV #KSHV #HSV1 #HSV2 #VZV #HHV6 #TLR2 #TLR3 #TLR4 #TLR5 #TLR7 #TLR9

virologyj.biomedcentral.com/track/pdf/10...

Promotion of TLR7-MyD88-dependent inflammation and autoimmunity in mice through stem-loop changes in Lnc-Atg16l1 - Nature Communications TLR7 has been shown to promote inflammatory autoimmunity. Here the authors investigate whether changes in RNA structure affect TLR signaling and show that a TLR7 binding lncRNA Lnc-Atg16l1 promotes de...

Discovery alert: Lnc-Atg16l1 RNA binds TLR7, amplifies #TLR7 signaling, boosting MyD88-dependent inflammation & autoimmunity in mice. Structural changes matter! #Autoimmunity #Research PMID:39587108, Nat Commun 2024, @NatureComms doi.org/10.1038/s414...

1/2 hormones, sex chromosomes, and their interactions, acting in a cell type– and region-specific manner.

#TLR7 plays a pivotal role in sex-specific microglial responses, particularly in the #IFN #pathway, which contributes to demyelination.

Tlr7 drives sex differences in age- and Alzheimer’s disease–related demyelination Alzheimer’s disease (AD) and other age-related disorders associated with demyelination exhibit sex differences. In this work, we used single-nuclei transcriptomics to dissect the contributions of sex ...

In @science.org this week: Li Gan & colleagues show the X-linked gene #Tlr7 determines #SexDifferences in #demyelination. Moreover, depletion or inhibition of TLR7 protects against demyelination in mouse model of #tau- mediated demyelination!

Promotion of TLR7-MyD88-dependent inflammation and autoimmunity in mice through stem-loop changes in Lnc-Atg16l1 - Nature Communications TLR7 has been shown to promote inflammatory autoimmunity. Here the authors investigate whether changes in RNA structure affect TLR signaling and show that a TLR7 binding lncRNA Lnc-Atg16l1 promotes de...

www.nature.com/articles/s41...

“our findings demonstrate a general mechanism involving how self-RNA structure affect innate sensors-triggering innate response and autoinflammation, and provide a potential strategy for controlling TLR-related autoimmune diseases.”

#TLR7 #lupus #SLE