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A Central Role for STAT3 in Gammaherpesvirus-Life Cycle and -Diseases #EBV #KSHV #MECFS #LongCovid

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Oncoviruses and Their Role in Human Cancer: Types, and Global Impact - OncoDaily Oncoviruses and Their Role in Human Cancer: Types, and Global Impact / cancer, cancer-causing viruses, Epstein-Barr virus cancer, HPV and cancer, OncoDaily,

Oncoviruses and Their Role in Human Cancer: Types and Global Impact

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#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Oncoviruses #OncogenicViruses #VirusInducedCancer #EBV #KSHV #HPV #HBV #HCV #HTLV-1

Better late than never: a unique strategy for late gene transcription in the beta- and gammaherpesviruses During lytic replication, herpesviruses express their genes in a temporal cascade culminating in expression of “late” genes. Two subfamilies of herpesviruses, the beta- and gammaherpesviruses (includi...

Better late than never: a unique strategy for late gene transcription in the beta- and gammaherpesviruses #EBV #KSHV #XPB #MECFS #LongCovid

pmc.ncbi.nlm.nih.gov/articles/PMC...

The Human Cytomegalovirus Transmembrane Protein pUL50 Induces Loss of VCP/p97 and Is Regulated by a Small Isoform of pUL50 | Journal of Virology Targeting the endoplasmic reticulum (ER) by viral proteins may affect ER-associated protein homeostasis. During human cytomegalovirus (HCMV) infection, pUL50 targets the ER through its transmembrane d...

journals.asm.org/doi/10.1128/...

"These proteins are conserved in other herpesviruses."

"pUL34 of herpes simplex virus 1 ( #HSV1), BFRF1 of Epstein-Barr virus ( #EBV), and ORF67 of Kaposi’s sarcoma-associated herpesvirus ( #KSHV) are functional homologs of pUL50 of HCMV." #CMV

STAT3 Regulates Lytic Activation of Kaposi's Sarcoma-Associated Herpesvirus Lytic activation of Kaposi's sarcoma-associated herpesvirus (KSHV) from latency is a critical contributor to pathogenesis and progression of KSHV-mediated disease. Development of targeted treatment st...

STAT3 Regulates Lytic Activation of Kaposi's Sarcoma-Associated Herpesvirus #KSHV

www.ncbi.nlm.nih.gov/pmc/articles...

Frontiers | A Central Role for STAT3 in Gammaherpesvirus-Life Cycle and -Diseases Having co-evolved with humans, herpesviruses have adapted to exploit the host molecular machinery to ensure viral persistence. The cellular protein Signal Tr...

A Central Role for STAT3 in Gammaherpesvirus-Life Cycle and -Diseases #EBV #KSHV

www.frontiersin.org/journals/mic...

Hamsters with long Covid exhibits a neurodegenerative signature in the brainstem After infection with SARS-CoV-2, patients may present with one or more symptoms that appear or persist over time, including fatigue, respiratory, cardiovascular and neurological disorders. Neurologica...

Hamsters with #LongCovid exhibits a neurodegenerative signature in the brainstem #SARSCoV2 #STAT3 #MECFS #EBV #KSHV #Bartonella

www.biorxiv.org/content/10.1...

Deep learning enhances the prediction of HLA class I-presented CD8+ T cell epitopes in foreign pathogens - Nature Machine Intelligence Accurate prediction of immunogenic CD8+ T cell epitopes would greatly accelerate T cell vaccine development. A new deep learning model, MUNIS, can rapidly identify HLA-binding, immunogenic and immunod...

Deep learning enhances the prediction of HLA class I-presented CD8+ T cell epitopes in foreign pathogens #EBV #KSHV #CMV #MECFS #LongCovid

www.nature.com/articles/s42...

Toll-like receptor-mediated innate immunity against herpesviridae infection: a current perspective on viral infection signaling pathways #EBV #CMV #KSHV #HSV1 #HSV2 #VZV #HHV6 #TLR2 #TLR3 #TLR4 #TLR5 #TLR7 #TLR9

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Toll-like receptor-mediated innate immunity against herpesviridae infection: a current perspective on viral infection signaling pathways #EBV #CMV #KSHV #HSV1 #HSV2 #VZV #HHV6 #TLR2 #TLR3 #TLR4 #TLR5 #TLR7 #TLR9

bsky.app/profile/rene...

Toll-like receptor-mediated innate immunity against herpesviridae infection: a current perspective on viral infection signaling pathways #EBV #CMV #KSHV #HSV1 #HSV2 #VZV #HHV6 #TLR2 #TLR3 #TLR4 #TLR5 #TLR7 #TLR9

virologyj.biomedcentral.com/track/pdf/10...

Frontiers | A Central Role for STAT3 in Gammaherpesvirus-Life Cycle and -Diseases Having co-evolved with humans, herpesviruses have adapted to exploit the host molecular machinery to ensure viral persistence. The cellular protein Signal Tr...

A Central Role for STAT3 in Gammaherpesvirus-Life Cycle and -Diseases #EBV #KSHV #MECFS #LongCovid

www.frontiersin.org/journals/mic...

Human Cytomegalovirus Replication Is Inhibited by the Autophagy-Inducing Compounds Trehalose and SMER28 through Distinctively Different Mechanisms | Journal of Virology ABSTRACT Human cytomegalovirus (HCMV) is the top viral cause of birth defects worldwide, and current therapies have high toxicity. We previously reported that the mTOR-independent autophagy-inducing d...

journals.asm.org/doi/10.1128/...

"In the case of #EBV and #KSHV, autophagy is blocked prior to the fusion of the autophagosome and lysosome, and this is associated with a specific reduction in Rab7 levels."

Human Cytomegalovirus Replication Is Inhibited by the Autophagy-Inducing Compounds Trehalose and SMER28 through Distinctively Different Mechanisms | Journal of Virology ABSTRACT Human cytomegalovirus (HCMV) is the top viral cause of birth defects worldwide, and current therapies have high toxicity. We previously reported that the mTOR-independent autophagy-inducing d...

journals.asm.org/doi/10.1128/...

"Recent studies, however, indicate that some herpesviruses, including Epstein-Barr virus ( #EBV), Kaposi's sarcoma-associated herpesvirus ( #KSHV), and varicella-zoster virus ( #VZV), may use autophagic membranes for this secondary envelopment."

Human Cytomegalovirus Replication Is Inhibited by the Autophagy-Inducing Compounds Trehalose and SMER28 through Distinctively Different Mechanisms | Journal of Virology ABSTRACT Human cytomegalovirus (HCMV) is the top viral cause of birth defects worldwide, and current therapies have high toxicity. We previously reported that the mTOR-independent autophagy-inducing d...

Human Cytomegalovirus Replication Is Inhibited by the Autophagy-Inducing Compounds #Trehalose and SMER28 through Distinctively Different Mechanisms #CMV #EBV #KSHV #VZV #MECFS #LongCovid

journals.asm.org/doi/10.1128/...

1/2025 Issue ➡️ www.embopress.org/toc/17444292...
functional domains in L. pneumophila, analysis of human interactomes, increased sensitivity in cross-linking mass spectrometry

Cover (@TeamSciStories): cis-regulatory elements in #KSHV and proximity to target over viral lifecycle @brittaspen