🔥Hot Off the Press | PLD4 mutations→ #SLE
This #Nature study (Qintao Wang et al.) identifies recessive #PLD4 loss-of-function mutations in SLE, revealing its key role in immune balance. PLD4 loss→ ssNA buildup→ #TLR7 /#TLR9 overactivation → #IFN surge→ autoantibodies→ SLE.