A conserved upstream element in the mouse Csf1r locus contributes to transcription in hematopoietic and trophoblast cells This work describes the functional characterization of a regulatory element within the Csf1r locus.

Emma Maxwell, David Hume, Sebastien Jacquelin and colleagues report that "A conserved upstream element in the mouse #Csf1r locus contributes to transcription in hematopoietic and trophoblast cells"

Fibroblasts promote the progression of benign prostatic hyperplasia through colony-stimulating factor 1 receptor-mediated RTK signaling in prostatic epithelial cells - Molecular Biomedicine Benign prostatic hyperplasia (BPH) is a prevalent condition characterized by nonmalignant proliferation of epithelial and stromal components in the prostate, frequently resulting in lower urinary trac...

#Research
Fibroblasts promote the progression of benign prostatic hyperplasia through colony-stimulating factor 1 receptor-mediated RTK signaling in prostatic epithelial cells doi.org/10.1186/s435...

#BenignProstaticHyperplasia #Fibroblasts #Sunitinib #RTK #Signaling #CSF1R

In this #JournalClub, Josh Chan of @ucalgary.bsky.social examines the work of Keeble et al. (2024), finding that #CSF1R is a promising therapeutic target for posttraumatic #osteoarthritis and quadriceps atrophy following ACL injury ✍️

🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

📰New & Featured | A recent paper in #Science Signaling (Aurora CALLAHAN, et al): #CSF1R-CAR T cells don’t just kill their targets, they activate #CSF1R signaling in surviving cells.
#CAR #CART #ScienceSignaling #CSF1

These findings may suggest consideration of interventions targeting microglia specifically in the treatment of patients with FIRES.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #CSF1R #FIRES #NORSE #statusepilepticus

On Wednesday, Vigil Neuroscience announced that the IGNITE phase 2 trial in ALSP patients has been discontinued.

Find out more and read their letter to the ALSP community: alextlc.org/.../vigil-ne...

#alextlc #helptocope #helptohope #leukodystrophy #alsp #hdls #csf1r

FDA approves Deciphera’s Romvimza for rare tumour type - PharmaTimes Tenosynovial giant cell tumours can cause pain, stiffness, swelling and movement limitations

#biopharmaceuticals #DecipheraPharmaceuticals #Romvimza #tenosynovialgiantcelltumours #TGCT #vimseltinib #FDAapprovel #Deciphera #raretumourtype #symptomatictenosynovialgiantcelltumours #tyrosinekinaseinhibitor #CSF1R #CSF1Rinhibitor #MOTIONclinicaltrial
pharmatimes.com/news/fda-app...

Researchers identify genetic mutations for rare disorder causing cognitive decline A rare cause of hereditary cognitive decline known as CSF1R-Related Disorder (CSF1R-RD) gets its name from mutations in the CSF1R gene, discovered by Mayo Clinic. Memory loss occurs as the condition a...

Researchers identify genetic mutations for rare disorder causing cognitive decline
medicalxpress.com/news/2024-09...

#Neuroscience
#CognativeDecline
#Genetics
#CSF1R
#Mutations

Researchers identify genetic mutations for rare disorder causing cognitive decline
medicalxpress.com/news/2024-09-genetic-mut...

#Neuroscience
#CognativeDecline
#Genetics
#CSF1R
#Mutations