#EPITUBE: Does prophylactic #norepinephrine reduce post-induction severe hypotension in cardiac surgery? This #RCT by Gaillard et al. found no reduction in severe hypotension, #AKI, ventilatory duration, or ICU length of stay vs on-demand ephedrine.
bjanaesthesia.org/article/S0007-0912(25)00795-0/
Interested in neuromodulators, especially #norepinephrine / #noradrenaline? Check out this #Naturemethods paper hot off the press from the Patriarchi lab on next-generation NE sensors. It was a pleasure to contribute to this team effort. A genuinely 💡enlightening 💡 advance for monitoring NE in vivo.
✨ Astrocyte Crosstalk: Simultaneous #norepinephrine & #astrocyte calcium imaging in the hippocampus.
👁️ Precision: Mapping discrete NE release in the visual cortex.
By combining our expertise, we developed indicators that offer:
🟢🔴 Dual-color flexibility: High-sensitivity green & red #sensors.
🧠 Complex Dynamics: Reliable tracking of #norepinephrine + neuronal activity.
Tracking #norepinephrine in vivo just got a major upgrade and it was a massive team effort led by @tpatriarchi.bsky.social .
Have a look at 🟢nLightG2 and 🔴nLightR2 on Nature Methods.
Kudos to all the great scientists involved!
ValentinLRohner, Paul Lamothe-Molina & Zacharoula Kagiampaki! 🧵
The most sensitive green and red #norepinephrine #sensors engineered to date are out in #naturemethods! Deeply grateful to all our funders and contributors who made this work possible. A true team effort. @erc.europa.eu @snsf.ch doi.org/10.1038/s415...
Dreams happen most often during REM when memory chemicals #serotonin and #norepinephrine are shut off and the free associative #acetylcholine neurotransmitter chemical runs wild.
Lucid dreaming blurs the lines between reality and dreaming and helps you remember more of your dream. #DreamJournals
#Propofol can directly target the #locuscoeruleus #norepinephrine neurone axons to suppress presynaptic norepinephrine release as an in vivo presynaptic mechanism of its #generalanaesthesia effects
www.bjanaesthesia.org/article/S0007-0912(25)00...
#Research
E3 ligase #CHIP restoration facilitates the effect of α1-adrenoceptor blockage on alleviating #lipopolysaccharide-caused cardiac fibrosis via downregulating TGF-BR1 expression and Smad2/3 activation doi.org/10.1186/s435...
#Norepinephrine #CardiacFibrosis #Fibroblast
#pharmacology14
#VASOPRESSORS #Pharmacology #NOREPINEPHRINE #MedStudent #ACTION #KEYiNFO #PHENYLEPHRINE #NursingNotes #MedSchool #EPINEPHRINE #VASOPRESSIN #NursingPharmacology #MedicalEducation #V1V2AGONIST #ALPHA1AGONIST
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Grateful to our collaborators and lab team for their insights and dedication.
📄 Read the full study: sciencedirect.com/science/arti...
#Neurobiology #Endocannabinoids #MentalHealth #ScienceThread #Norepinephrine
Crumbled paper in the shape of a brain with a portion torn into pieces. Working in rats, researchers elucidated a molecular mechanism that allows the brain to distinguish similar memories or experiences. Image credit: Shutterstock/Lightspring
Researchers uncover a biological mechanism explaining how some #TraumaticMemories remain distinct in the #brain. In PNAS Journal Club: www.pnas.org/post/journal...
#memory #PTSD #norepinephrine #amygdala #microRNA
ADHD doesn’t mean you’re unmotivated -- it means your brain needs a different kind of fuel.
Hot Tip:Send this to someone who’s running on mental fumes and doesn’t know why.
#ADHD #Norepinephrine #BrainChemistry #EnergyLevels #AttentionSpan #Neuroscience
Top: Representative images showing the spatial localization of labeled dmPFC neurons with BFP (blue) or retrobeads (red), taken using 10 X (upper) or 40 X (lower) objectives. The majority of labelled neurons were located in layer II/III of dmPFC. Scale bars, 100 μm (10 X) and 25 μm (40 X). Bottom: Summary on the neural circuit mediating the transition from memory retrieval to freezing behavior. Presentation of CS+ activates LA neurons and TeA neurons. The activated LA neurons activate dmPFC T-neurons, which in turn activate dmPFC S-neurons and LC neurons. S-neurons receive inputs from TeA and send their outputs to BLA, which projects to PAG to enable freezing behavior. Activated LC neurons release NE in the dmPFC via their projections.
Which neural circuits allow memory retrieval to influence behaviors? This study shows how #fear #memory activation initiates & sustains #FreezingBehavior in mice via the interplay of #norepinephrine & activation of different prefrontal #neuron subtypes @plosbiology.org 🧪 plos.io/3TGqt7a
Top: Representative images showing the spatial localization of labeled dmPFC neurons with BFP (blue) or retrobeads (red), taken using 10 X (upper) or 40 X (lower) objectives. The majority of labelled neurons were located in layer II/III of dmPFC. Scale bars, 100 μm (10 X) and 25 μm (40 X). Bottom: Summary on the neural circuit mediating the transition from memory retrieval to freezing behavior. Presentation of CS+ activates LA neurons and TeA neurons. The activated LA neurons activate dmPFC T-neurons, which in turn activate dmPFC S-neurons and LC neurons. S-neurons receive inputs from TeA and send their outputs to BLA, which projects to PAG to enable freezing behavior. Activated LC neurons release NE in the dmPFC via their projections.
Which neural circuits allow memory retrieval to influence behaviors? This study shows how #fear #memory activation initiates & sustains #FreezingBehavior in mice via the interplay of #norepinephrine & activation of different prefrontal #neuron subtypes @plosbiology.org 🧪 plos.io/3TGqt7a
Top: Representative images showing the spatial localization of labeled dmPFC neurons with BFP (blue) or retrobeads (red), taken using 10 X (upper) or 40 X (lower) objectives. The majority of labelled neurons were located in layer II/III of dmPFC. Scale bars, 100 μm (10 X) and 25 μm (40 X). Bottom: Summary on the neural circuit mediating the transition from memory retrieval to freezing behavior. Presentation of CS+ activates LA neurons and TeA neurons. The activated LA neurons activate dmPFC T-neurons, which in turn activate dmPFC S-neurons and LC neurons. S-neurons receive inputs from TeA and send their outputs to BLA, which projects to PAG to enable freezing behavior. Activated LC neurons release NE in the dmPFC via their projections.
Which neural circuits allow memory retrieval to influence behaviors? This study shows how #fear #memory activation initiates & sustains #FreezingBehavior in mice via the interplay of #norepinephrine & activation of different prefrontal #neuron subtypes @plosbiology.org 🧪 plos.io/3TGqt7a
⁉️ 💉 What is the optimal dose of #norepinephrine to prevent hypotension following spinal anesthesia in Cesarean delivery? @IARS_Journals
🔗 Read more here: journals.lww.com/anesthesia-a...
Is #perioperative AKI caused by #hypotension despite #norepinephrine therapy, or by norepinephrine itself?
#www.bjanaesthesia.org/article/S0007-0912(25)00...
Open Access paper: Continuous versus bolus #norepinephrine administration to treat #hypotension after induction of general anaesthesia in low-to-moderate risk noncardiac surgery patients.
To bolus #noradrenaline or to start an #infusion? Thomsen et al. suggest it makes no difference to post-induction #hypotension in low-risk noncardiac surgery patients. #BJA #GA #norepinephrine
Astrocytes, the star-shaped glial cells known for providing structural and metabolic support to neurons, may actually play a role in the mechanisms underlying depression. Image credit: JOSE CALVO/Science Source
#Astrocytes may play a critical role in #depression. In PNAS Journal Club: www.pnas.org/post/journal...
#neuron #stress #norepinephrine #GlialCells #MentalHealth
#Neurotransmitters are signals that play roles in inter-kingdom #signaling. Our study identifies a #chemoreceptor in #Pseudomonas #aeruginosa responsible for triggering #chemotaxis to #dopamine, #serotonin, #epinephrine & #norepinephrine.
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
Overlooked Cell Type Orchestrates Brain Rewiring
www.newswise.com/articles/ove...
#astrocytes #synapse #Norepinephrine #Newswise #orchestrates #BrainHealth
Felt sense of ADHD vs AuDHD.
Check out the full episode:
- Spotify: open.spotify.com/episode/6ejF...
- Youtube: youtu.be/0Ix8PDO3fKU
#neurodiversity #adhd #autism #neuroscience #mentalhealth #norepinephrine
Norepinephrine levels and neurodiversity.
Check out the full episode:
- Spotify: open.spotify.com/episode/6ejF...
- Youtube: youtu.be/0Ix8PDO3fKU
#neurodiversity #adhd #autism #neuroscience #mentalhealth #norepinephrine
References:
- doi.org/10.3389/fnin...
Norepinephrine levels in ADHD and Autism.
Check out the full episode:
- Spotify: open.spotify.com/episode/6ejF...
- Youtube: youtu.be/0Ix8PDO3fKU
#neurodiversity #adhd #autism #neuroscience #mentalhealth #norepinephrine
References:
- doi.org/10.3389/fnin...
- doi.org/10.1016/j.bb...
Flávia Alves Verza et al. demonstrated for the first time that oral squamous cell #carcinoma cells secrete stress-related #norepinephrine, and this event can be further regulated by the tobacco carcinogen NNK. Read the research here ➡️ buff.ly/0KXYIZ1
On a white background are the words in blue lettering Cranio-Electro Stimulation (CES) then our website address mindalive.com. In the top right corner is a long with a gold brain on top of a white seagull silhouette and a round blue area underneath. In the top left and right bottom corners are 3 gold triangles just meant to accentuate the words.
#CranioElectroStimulation (CES) is a non-invasive #BrainStimulation technique that applies a small pulsed electric current across a person’s head. It stimulates #Endorphin, #Serotonin & #Norepinephrine neurotransmitter production.
mindalive.com/pages/cranio...
#MindAlive #Anxiety #Sleep #Pain
Effect of Sleeping pills
www.linkedin.com/pulse/effect...
#sleepingpills #ambien #zolpidem #benzodiazepine #norepinephrine #MaikenNedergaard #detoxifying #cerebrospinalfluid #CSF #NREM #qlymphaticsystem #bloodvessels #memory
