Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages Wu et al. reveal an inverse relationship between psoriasis severity and postprandial APOB48 levels in humans. Using a newly developed photoconvertible APOB knockin mouse and intestinal organoids, they...

#WeekendRead! #SkinGutAxis! Wu &co show @cp-cellmetabolism.bsky.social that #psoriasis induces a population of #intestinal macrophages that produce #IL1b & alters lipid absorption, increasing epithelial lipid accumulation, thus fostering gut inflammation!

Excellent seminar by Dr. Kory Lavine during his visit to our center yesterday, sharing important insights into #IL1B in #fibroblast biology, and mechanisms of #HeartFailure. Great science and stimulating conversations.

Targeting the NLRP3 inflammasome–IL-1β pathway in type 2 diabetes and obesity - Diabetologia Increased activity of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome–IL-1β pathway is observed in obesity and contributes to the development of type 2 diabetes and its compli...

Targeting the NLRP3 inflammasome–IL-1β pathway in type 2 diabetes and obesity 👩‍🔬🥼🧪👨‍🔬 @diabetologiajnl.bsky.social #Inflammation #Diabetes #NLRP3 #IL1b #type2diabetes #obesity 👇👇👇

link.springer.com/article/10.1...