Multi-epitope TGFβ vaccination in #PancreaticCancer targeting specific immunological correlates neutralizes TGFβ-mediated #Immunosuppression and enhances anti-tumor responses to improve clinical outcomes.

#OpenAccess: doi.org/10.1038/s413...

Figure 1 Hypothesis. CRC, colorectal cancer; dMMR, deficient mismatch repair; HGD, high-grade dysplasia; HP, hyperplastic polyp; LGD, low-grade dysplasia; pMMR, proficient mismatch repair; SSL, sessile serrated lesion; SSL-D, sessile serrated lesion with dysplasia; TSA, traditional serrated adenoma.

From our March issue, "Risk of deficient mismatch repair colorectal cancer and precursors after kidney transplantation: A nationwide study," by Zwart et al
doi.org/10.1016/j.aj...
#KidneyTransplant #ColorectalCancer #Transplantation #Immunosuppression

Dr. Wolfe discusses
- The HOPE Act's impact on practice
- #Immunosuppression, #antivirals, and opportunistic infections
- Organ-specific surveillance for #HIV patients
- Ethics and equitable treatment for patients and donors

#IDsky #medsky #transplantsky

Systematic Review of #Immunosuppression after #CAR-T Therapy for #PTLD

#VisualAbstract by Edgar V. Lerma 🇵🇭

www.kireports.org/article/S2468-0249(26)02...

New 📽️: Cristina López & Bryan Contreras present their findings on 9,10-DiHOME, a linoleic acid-derived #leukotoxin. This lipid mediator may increase susceptibility to bacterial infection in late-stage #cirrhosis

👉 youtu.be/9fIUZM7Df1E

#Inflammation #Immunosuppression #LiverSky
@idibaps.bsky.social

"Immediate and Gradual Withdrawal of Immunosuppression After Kidney Graft Loss Lead to Similar Outcomes"

Read more here: shorturl.at/13QBz

#immunosuppression #withdrawal #kidney #transplantation #loss @esottransplant.bsky.social

Kidney Outcomes in #ANCA-Glomerulonephritis According to Induction #Immunosuppression and #Histopathology

#VisualAbstract by @DrPallaviPrasad

www.kireports.org/article/S2468-0249(26)00...

ISHLT Consensus Statement on STS and Lung Transplantation on the JHLT Podcast Joined by the three document leads, JHLT the Podcast discusses the latest Consensus Statement from ISHLT, exploring short telomere syndrome (STS) and lung transplantation.

Learn about:
🫁 Assessing patients for STS
🔎 Which patients to screen
📈 How the diagnosis influences #transplant decision making, risk assessment
💊 Impacts to #immunosuppression
🩺 Extrapulmonary comorbidities
🔮 Future areas for research

#medsky #pulmsky #transplantsky

www.ishlt.org/about/news-d...

Safer, more durable kidney transplants were the focus at #WTC2025. Discussions centered on personalized immunosuppression, innovative trial designs, managing side effects, and improving adherence through patient education. #TXPforAll #Immunosuppression tinyurl.com/3czwpkmb

A potential breakthrough for recurrent FSGS after kidney transplant 🩺. Dual B cell and plasma cell targeting induced remission and improved kidney function in patients unresponsive to standard therapies. #TXPforAll #Transplantation #Immunosuppression tinyurl.com/mr37ukc4

Oncogenic activation of STAT-5 induces oncostatin M (OSM), driving metabolic reprogramming, #TumorMicroenvironment remodelling, and #Immunosuppression in myeloproliferative neoplasms and related malignancies. #Medsky

#OpenAccess: doi.org/10.1038/s413...

Peripheral TERT- positive leukocytes as a biomarker of the local and systemic immune failure in early-stage lung adenocarcinoma progression - Molecular Biomedicine The prognosis of early-stage lung adenocarcinoma (LUAD) worsens significantly during the progression from adenocarcinoma in situ/minimally invasive adenocarcinoma (AIS/MIA) to invasive adenocarcinoma ...

#Research
Peripheral TERT- positive #leukocytes as a #biomarker of the local and systemic immune failure in early-stage lung adenocarcinoma progression doi.org/10.1186/s435...

#LungAdenocarcinoma #LUAD #Invasive #Adenocarcinoma #Immunosuppression

🗾🎌 This work by Kanazawa University is an exciting step toward truly precision immunomodulation, moving beyond blanket #immunosuppression to selectively retrain the #immunesystem. This could transform how we manage #autoimmune and allergic diseases.
www.linkedin.com/posts/drmelv...

Promising Phase 2 Data for Tegoprubart in KT | Docwire News John Gill, MD, discussed phase 2 findings presented at ASN Kidney Week 2025 on tegoprubart for immunosuppression in kidney transplantation.

John Gill, MD, spoke with us about the latest data on tegoprubart vs. tacrolimus for immunosuppression in kidney transplantation. #nephsky #nephrology #kidneytransplantation #immunosuppression www.docwirenews.com/post/promisi...

Transplantation Without Immunosuppression. Stanford transplant immunologists have developed a transplantation technique employing an induced hybrid or chimeric immune system in the recipient. #transplantation #diabetes #hybrid #stemcell #immunosuppression

This review outlines how EV-ncRNAs drive #PreMetastaticNiche formation by shaping #immunosuppression, #VascularRemodeling, #inflammation, metabolism, and #fibroblast activation across #cancers, highlighting their promise as #biomarkers.

#OpenAccess: doi.org/10.1016/j.ge...

This latest review elaborates on how #Lactylation contributes to resistance in #Oncology by sustaining #Stemness, enhancing DNA repair, reprogramming metabolism, inhibiting #Ferroptosis, and promoting #Immunosuppression. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

📰New & Featured | A study in #Cell introduces a new #macrophage-targeted #immunocytokine (#MiTE) reprograms #TREM2⁺ TAMs and locally activates #T/NK cells, delivering strong #anti-tumor immunity without #IL-2 toxicity.
🌟Opens up new path to overcome #immunosuppression.

Systemic immunosuppression from ultraviolet radiation exposure inhibits cancer immunotherapy Background Ultraviolet radiation (UVR) affects local cutaneous and systemic immunity acutely. The wavelength, pattern and intensity of UVR exposure, individual skin phototype and immune state of indiv...

🩺 HOW THIS STUDY MIGHT AFFECT RESEARCH,
PRACTICE OR POLICY
Systemic effects of long-term UVR exposure lead to systemic #immunosuppression, which impacts #melanoma & non-melanoma #CancerImmunotherapy

These findings suggest that patients may benefit
from avoiding ☀️sun exposure during #Immunotherapy

Researchers identify #VCP as a key regulator of CD8+ T cell suppression in #HCC, showing that targeting VCP restores T cell #Antitumor function and synergizes with #AntiPD1 therapy to overcome #Immunosuppression in the #TME. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

🤔 Personalize #immunosuppression, ie #tacrolimus, in kidney txp patients?

@drpriyajohn discusses the tacrolimus C/D ratio & potential shift in transplant care

Infographic by @krithicism

https://ow.ly/rMPG50XhaUy

https://ow.ly/5PiE50XhaUs

This study shows that Bcl6 maintains #Treg cell stability and suppressive function in #HNSCC, and suggests that targeting Bcl6 could disrupt Treg-driven #Immunosuppression, highlighting a promising #therapeutic strategy for treating HNSCC. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Post-translational acylation modulates immunosuppression and immunotherapy efficacy in hepatocellular carcinoma - Genes & Immunity Genes & Immunity - Post-translational acylation modulates immunosuppression and immunotherapy efficacy in hepatocellular carcinoma

Post-translational #acylation modulates #immunosuppression and #immunotherapy #efficacy in #hepatocellular #carcinoma
#livercancer
#Genes & #immunity @springernature.com
www.nature.com/articles/s41...

MLKL PARylation in the endothelial niche triggers angiocrine necroptosis to evade cancer immunosurveillance and chemotherapy - Nature Cell Biology Yang, Li, Huang, Ji, Luo, Jiang and colleagues report that chemotherapy induces MLKL PARylation and necroptosis in tumour endothelial cells, which in turn affects tumour-associated macrophages and CD8⁺ T cells, promoting immunosuppression and tumorigenesis.

💫NEW: Yang, Li, Huang, Ji, Luo, Jiang et al report that chemotherapy induces MLKL PARylation and #necroptosis in tumor endothelial cells, which in turn affects tumor-associated #macrophages and CD8⁺ T cells, promoting #immunosuppression and tumorigenesis.
👉https://rdcu.be/eHUob
bit.ly/4njRM4p

How Long Is Your RSV Immunization Protective? The answer comes from a Vanderbilt University helmed study of subjects in 20 states. #rsv #vaccination #hospitalization #immunosuppression #cardiovascular

Some pearls from noon conference held by our junior chief resident Aparna Rathnam about step-by-step diagnostic strategies for patients on immunosuppression! #MedSky #elmhurstmedicine #immunosuppression

Novel Approach To Transplant Immunosuppression directs the body’s immune system to censor itself permitting transplanted human organs to flourish without medicinal immunosuppression. #transplantation #immunosuppression #Treg #antibodies #presensitized

Gene Editing Allows Pancreatic Islet Cell Transplantation Without Immunosuppression. #diabetes #insulin #isletcells #transplantation #geneediting #immunosuppression

Is your home a health hazard? 15 surprisingly filthy everyday items, from taps to toothbrushes Your water bottle could harbour 40,000 times more bacteria than your toilet seat. And that’s just the tip of the dirtberg

Particularly relevant for patients with a weakened immune system #immunosuppression #infections www.theguardian.com/society/2025...